High content screening automated systems

High-throughput automated imaging systems, also sometimes referred to as high content screening (HCS) systems, enable the study of specific cell types within a mixed population of cells (Giuliano, 1997). Some primary cell types are dependent on interactions with other cell types, making their cultivation in isolation impossible, at least at the present time. Even when primary cells are not dependent on interactions with other cell types, primary cell preparations are almost never 100% pure, which could potentially lead to problems in assay quality and reproducibility. Systems such... 

The use of dual microelectrodes and the implementation of an automated distance control in the electrochemical robotic system drastically improved the readout of the NO assays and made electrochemical high-content screening of released NO from endothelial cells possible. 

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