Headache classification

Headache Classification Committee of the International Headache Society. The International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004 24(Suppl 1 ) 1—160. 

The Headache Classification Committee of the International Headache Society (1988) has developed diagnostic criteria for classification of headache disorders, cranial neuralgias, and facial pain the criteria include painful and nonpainful disorders of the entire head and are based on the diagnosis rather than on the underlying pain mechanisms. 

This last consideration may be a primary obstacles in the long-term relief of headache. Classification of Headaches... 

Lipton RB, Bigal ME, Steiner MB, et al. Classification of primary headaches. Neurology 2004 63 427-435. 

Silberstein SD, Lipton RB, Dalessio DJ. Overview, diagnosis, and classification of headache. In Silberstein SD, Lipton RB, Dalessio DJ, eds. Wolff s Headache and Other Head Pain. 7th ed. New York Oxford University Press, 2001 6-26. 

Based on a review of this drug (isometheptene mucate) by the National Academy of Sciences-National Research Council or other information, FDA has classified the other indication as possibly effective in the treatment of migraine headache. Final classification of the less-than-effective indication requires further investigation. 

DOT CLASSIFICATION 6.1 Label KEEP AWAY FROM FOOD SAFETY PROFILE Poison by ingestion, skin contact, intraperitoneal, and intravenous routes. Moderately toxic via inhalation and subcutaneous routes. Human systemic effects by inhalation nausea or vomiting, headache, unspecified eye effects. Experimental teratogenic and reproductive effects. A skin irritant. Combustible Uquid when exposed to heat or flame. To fight fire, use foam, CO2, dry chemical. Incompatible with oxidizing materials, heat, and flame. When heated to decomposition it emits acrid smoke and irritating fumes. 

OSHA PEL TWA 0.5 mg(As)/m3 DOT CLASSIFICATION 6.1 Label Poison SAFETY PROFILE A human poison by inhalation. Poison experimentally by inhalation and skin contact. A powerfully irritating military poison. Exposure yields cold-like symptoms, plus headache, vomiting and nausea. A nonpersistent gas. Decontamination is by use of chlorine or caustic soda in confined spaces. When heated to decomposition it emits toxic... 

DOT CLASSIFICATION 6.1 Label Poison SAFETY PROFILE Human poison by unspecified route. Experimental poison by ingestion, inhalation, skin contact, intraperitoneal, and intravenous routes. Human systemic effects by ingestion and inhalation somnolence, headache, abnormal brain recordings from specific areas of the central nervous system, cardiac and gastrointestinal changes. Mutation data reported. An eye and skin irritant. Less toxic than the para form, but is still highly toxic. 

DOT CLASSIFICATION Forbidden SAFETY PROFILE Poison by subcutaneous route. Can cause lowered blood pressure leading to headache, dizziness, and weakness. Used as an explosive. When heated to decomposition it emits toxic fumes of NOx. See also NITRATES. 

DOT CLASSIFICATION 8 Label Corrosive SAFETY PROFILE Poison by inhalation. Human systemic effects by inhalation wakefulness, muscle weakness, anorexia, headache, tinnitus, hypermotility, diarrhea, liver changes, dermatitis, fever. An experimental teratogen. Experimental reproductive effects. Questionable... 

DOT CLASSIFICATION 6.1 Label Poison SAFETY PROFILE Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by intramuscular route. Mutation data reported. Acute symptoms of exposure are headache, nausea, vomiting, weakness and stupor, cyanosis and methemoglobinemia. Chronic exposure can cause liver damage. Experimental reproductive effects. Combustible when exposed to heat or flame. See NITRATES for explosion and disaster hazards. To fight fire, use water spray or mist, foam, dry chemical, CO2. Vigorous reaction with sulfuric acid above 200°C. Reaction with sodium hydroxide at 130°C under pressure may produce the explosive sodium-4-nitrophenoxide. When heated to decomposition it emits toxic fumes of NOx. See also m-NITROANILINE, o-NITROANILINE, NITRO COMPOUNDS OF AROMATIC HYDROCARBONS, and ANILINE DYES. 

DOT CLASSIFICATION Forbidden SAFETY PROFILE Poison by ingestion and intraperitoneal routes. Moderately toxic by inhalation. Irritating to skin, eyes, and mucous membranes. Inhalation can cause headache and nausea. Causes mild narcosis. A very dangerous explosion hazard explodes when heated rapidly. Dissolution is exothermic and solutions of more than 50% can explode. Mixtures of 90% trinitromethane + 10% isopropyl alcohol in polyethylene bottles have exploded. Frozen mixtures with 2-propanol (10%) explode when thawed. Can explode during distillation. Mixtures with divinyl ketone can explode at 4°C. When heated to decomposition it emits toxic fumes of NOx. See also NITRO COMPOUNDS. 

TABLE 59—1. International Headache Society Classification System Focus on Migraine Headache... 

Synonyms Petroleum distillate Petroleum distillate light Classification Petroleum hydrocarbons Definition Mixture of volatile hydrocarbons obtained from petroleum Toxicology OSHA PELTWA400 ppm TDLo (parenteral, man) 57 mg/kg human systemic effects by parenteral route (cough, dyspnea, nausea, vomiting) mildly toxic by inh., ing. mod. skin/eye irritant skin contact may cause defatting vapor inh. can cause CNS depression, headache, unconsciousness TSCA listed Precaution Combustible exposed to heat or flame Hazardous Decomp. Prods. Heated to decomp., emits acrid smoke and irritating fumes... 

Classification Mixed petroleum hydrocarbons Definition Mixed isomer contg. 85% nonane and 15% trimethylbenzene Properties Colorless clear liq. petrol, odor misc. with abs. alcohol, benzene, ether, chloroform, CCI CS2, most org. soivs. insol. in water m.w. 150 sp.gr. 0.78 f.p. -70 C b.p. 157-196 C flash pt. (CC) 40 C ref. index 1.43 (20 C) KB value 32-37 Toxicology ACGIH TLV/TWA100 ppm LD50 (oral, rat) > 5 g/kg, (skin, rabbit) > 3 g/kg LCLo (inh., cat, 2.5 h) 10 g/m mildly toxic by inh. (irritation, CNS effects, headache, dizziness, confusion, fatigue) human eye irritant probably a mild to mod. skin irritation TSCA listed Precaution Combustible flamm. exposed to heat or flame explosive in vapor form when exposed to heat or flame reactive with oxidizing materials... 

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