Gastrointestinal Changes

Regional blood flow changes also occur in pregnant women and can affect drug distribution and elimination. Blood flow increases to the uterus, kidneys, skin, and mammary glands, with a compensatory decrease in skeletal muscle blood flow. At full term, blood flow to the uterus represents about 20-25% of cardiac output and renal blood flow is 20% of cardiac output (15). There is increased blood flow to the skin to dissipate the additional heat produced by the fetus (16). Blood 

TABLE 22.1 Body Fluid Spaces in Pregnant and Nonpregnant Women  

Modified from Frederiksen et al. Clin Pharmacol Ther 1986 40 321.  

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An adult male monkey died after consuming 0.73 mg/kg/day FireMaster FF-1 in the diet for 25 weeks (Allen et al. 1978 Lambrecht et al. 1978). The death was attributed to severe gastrointestinal changes, including ulcerative colitis. The only other animal in this study was a juvenile female who survived 50 weeks of a dietary dosage of 1.43 mg/kg/day. In another study, one juvenile female monkey that consumed 18 mg/kg/day FireMaster FF-1 in the diet died after 137 days of continuous exposure (Allen et al. 1978). Although only one or two monkeys were tested in tliese studies, effects characteristic of PBB... 

SAFETY PROFILE Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by intravenous route peritonitis, central nervous system, and gastrointestinal changes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of F", POx, and Na20. 

SAFETY PROFILE Poison by ingesdon, inhalation, intravenous, and intraperitoneal routes. Moderately toxic by skin contact, intratracheal, and subcutaneous routes. Human systemic effects coma, diarrhea, dyspnea, gastrointestinal changes, h permotility, nausea or vomiting, respirator depression. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx, POx, and SOx. 

DOT CLASSIFICATION 6.1 Label Poison SAFETY PROFILE Human poison by unspecified route. Experimental poison by ingestion, inhalation, skin contact, intraperitoneal, and intravenous routes. Human systemic effects by ingestion and inhalation somnolence, headache, abnormal brain recordings from specific areas of the central nervous system, cardiac and gastrointestinal changes. Mutation data reported. An eye and skin irritant. Less toxic than the para form, but is still highly toxic. 

SAFETY PROFILE Suspected carcinogen. Poison by subcutaneous route. Moderately toxic by ingestion. Human systemic effects by ingestion hallucinations or distorted perceptions, cyanosis, and gastrointestinal changes. Experimental reproductive effects. Mutation data reported. A skin irritant. Has been implicated in aplastic anemia. Can cause headache, weakness, anemia, liver injury. May be absorbed through skin. 

HEALTH SYMPTOMS Inhalation (respiratory obstruction, cough, sputum, pulmonary effects, gastrointestinal changes, irritates eyes, skin and nose) contact (severe dermatitis, bronchial spasm, conjunctivitis, lacrimation, skin sensitization). 

HEALTH SYMPTOMS inhalation (sneezing, cough, sore throat, irritates mucous membranes) skin absorption (headache, weakness, drowsiness, anemia, liver damage) ingestion (cyanosis, gastrointestinal changes, hallucinations or distorted perceptions) contact (erythema, papules, eczema, cataracts, stains skin, hair and nails yellow). 

Gastrointestinal changes possibly owing to hyperactive smooth muscle also may be noted, including... 

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