Going out of business

Changes to environmental computer applications occur rapidly, therefore, the list cannot remain current. New systems are being developed, vendors move or go out of business, and identified systems are being updated, sold to other vendors, tailored to new markets, or discontinued. 

The Problem A local store is going out of business and has advertised that all items are 60 percent off the original price. You buy a toaster oven that s currently marked 49.95. What will you pay for the toaster oven after the store applies the discount ... 

That pharmaceutical manufacturers are now totally committed to cGMPs as a fact of life, reluctantly admitted by the newer and inexperienced biopharmaceutical technology-based companies. Indeed, there are examples of young companies going out of business because they felt that this was an unnecessary bureaucratic process that would hinder the application of their wonderful new product. This attitude was perilous in the extreme because, ultimately, the FDA has to approve the drug and its process before it can be marketed. 

Try to put a positive spin on your answer, especially if you were fired for negative reasons. The company downsizing, going out of business, or some other reason that was out of your control is a perfectly acceptable answer. Remember, your answer will probably be verified. 

It is evident that with the trend to larger plants, the small producer is at a distinct disadvantage in that his costs, per unit ethylene, are higher than for the bigger producers. To sell his product competitively he may be forced to accept a lower than desired profit, or even go out of business. Of course, he can retire his small unit and get back into things with a new big unit. 

The same approach can be used for property calculations, because you may have multiple choices and each one has different APIs. It is possible that today you choose one vendor solution to do the work. Some time in the future you may switch to a different vendor for the purpose of cost savings, better algorithm, performance, or reliability. Or you may face a harder choice—the vendor you chose in the past is going out of business. The solution we described above for Molfile-Smiles conversion keeps your system closed for... 

Verify financial stability of the laboratory laboratories have been known to go out of business without notifying the client, thus jeopardizing the course of project activities. 

With worsening of the economy, both the federal and state governments may cut back on Medicare and Medicaid reimbursement to nursing homes. Thus these facilities may go out of business or have insufficient funds to reimburse us for the services of the program. 

When the reason for a replacement falls in the first general type, the only alternatives are to make the necessary changes or else go out of business. Under these conditions, the final economic analysis is usually reduced to a comparison of alternative investments. 

Your suppliers could raise their prices, deliver their products late or go out of business altogether. That leaves you with one less supplier, and customers that expect to find those products on your shelves. By the time you find a replacement supplier, some of your customers may have moved on. 

For a store s going-out-of business sale, a set consisting of a card table and four chairs is advertised at 233. The store has 31 tables and 98 chairs. 7 outlet manager arrives with 5000. What is the maximum number of sets the outlet manager can buy ... 

Demonstrate how the maintenanee and support of the COTS software/hardware will be eontinued should the original developers/suppliers go out of business or no longer be able to support their produets/serviees, or any other reason. 

With any two partners, there are always problems and issues to deal with. There are differences in goals and values (see Box 5.8). Those of us in industry deal with the marketplace we focus on return on investment. We are very cost conscious. We go out of business if we are not cost competitive. We are for-profit we have to provide a return to our shareholders, and we always have to keep the results of innovation as a competitive advantage. That is how we make money. And, of course, timing is everything. 

Common names have been given to sodium sulfate as a result of manufacturing methods. In rayon production, by-product sodium sulfate is separated from a slurry by filtration where a 7—10-cm cake forms over the filter media. Thus rayon cake was the term coined for this cake. Similarly, salt cake, chrome cake, phenol cake, and other sodium sulfate cakes were named. Historically, sulfate cakes were low purity, but demand for higher purity and controlled particle size has forced manufacturers either to produce higher quahty or go out of business. Sodium sulfate is mined commercially from three types of mineral evaporites thenardite, mirabilite, and high sulfate brine deposits (see Chemicals frombrine). 

Diversity of supplier is generally desirable, whether there is a gate fee payable by the supplier or the feedstock has to be paid for by the project company, so as to mitigate the risk of a single supplier going out of business. The duration of the fuel supply agreement usually exceeds the term of the finance. 

Regulatory compliance projects are often required as a result of changes in environmental or other legislation. If the government changes the rules on plant safety, emissions, or product specifications, then unless an exemption can be obtained, the plant must be modified or closed down. Regulatory compliance projects often have poor financial performance unless the costs of going out of business are considered. 

Going out of business is often a sudden and unplanned event for a laboratory. Under such circumstances, personnel from the lab ceasing operations may not show proper concern for complying with regulatory requirements. The party with the greatest stake in preserving the records of a study, namely the sponsor, may therefore have to assume responsibility for the preservation and transfer of the records to the sponsor s location and for notifying the FDA of the transfer. 

The GLP Principles do also direct attention the one fact of business life, the event that a test facility might go out of business, while giving no advice on the way to handle the archive situation in the case of a company merger. In this second case, there is probably no need for overmuch regulation. In the event of a merger, the already archived material may either stay at the present archive location, or it may be moved to the archive of the buyer . In the former case no special measures have to be taken, while in the latter one some documentation will be needed. The reason for this necessity is that it has to be mentioned in all final reports where the different materials, raw data, samples and specimens are to be stored. Since with the move to new archive locations this statement will not be true anymore, the new location of the various materials has to be given in an amendment to each study report, which can, however, take the form of a general statement that can be declared valid for all studies of a certain time period or of a certain denomination. 

Marginal producers who will either curtail production or go out of business when the price drops... 

There may be a lack of in-house expertise resulting in the need to contract out the work or the need to develop an in-house capability. Alternatively, there may be a lack of in-house facilities or equipment to handle the candidate drug. These issues need to be resolved quickly or else time penalties could be incurred. Other areas of risk include the sources of excipients and packaging components. Some excipients or packaging components may only be available from one supplier, with the risk that the supplier could go out of business. 

Once selection requirements have been created, the next step is to search for systems that meet the laboratory s needs. It is common for a few different vendors to offer systems for LBA automation. It is important to remember that by the time the system is validated, considerable time and effort will have been spent implementing the system the last thing a laboratory wants is to find that the vendor is going out of business or has only one service technician covering the entire country. A common... 

Xenophon is mostly remembered today as the author of the Anabasis, where he records the story of the 10 000 Greek soldiers from Cyrus s army that he led back home after the unsuccessful war with Artaxerxes. However, he has other calls on onr attention, the most relevant to this book being that he wrote the Oeconomicus, probably the world s first textbook of economics. It contains ideas that formed the basis, more than 2000 years later, of the first serious attempt to analyze economic phenomena, which was made by Adam Smith in An Inquiry into the Nature and Causes of the Wealth of Nations. Xenophon noted that there is a relation between the number of blacksmiths in a region and the prices that they can charge if there are too many, the price of their work falls, causing some to go out of business and helping to restore the value of the work of those that remain. This is effectively the first expression of what we now call the law of supply and demand. 

But say ycm ve not had enough shocks to your system to need the compound on a steady basis. Say, also, that your working and personal life is blissfully tranquil so you never need the conqxxind. Think how things will be when the [rfiannaomtical companies go out of business and the millions of tranquilizer-dependent wretches are cut off and going crazy You could trade or sell the compound for all the traffic would bear. You wouldn need to worry about the health food stores running out. You can grow it yourself. 

A related consequence of widespread adoption of a supply-in-creasing biotechnology product is lower prices for the farm product, as demand for most farm commodities is relatively Inelastic. A forthcoming bovine growth hormone is projected to Increase milk production 10 percent (27). Falling prices will press less efficient producers to alter their operations or go out of business. As few individuals will be able to enter the business, the industry will shrink and concentrate production in fewer firms. 

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