Growth hormone bovine

One technology uses bovine somatotropin (bST) produced by recombinant technology (38). Somatotropin [9002-72-6] is a growth hormone. The bST-supplemented cows provide an increase in milk output per cow or an increased feed efficiency. Recombinant bST, also known as recombinant bovine growth hormone (rBGH) is the synthetic analogue of a natural hormone that increases milk production in cows (39). The use of recombinant technology was approved by the FDA in 1993. The Commission of the European Community has recommended that the moratorium on commercial use of BGH be delayed until the year 2000. 

Structural Formula Proteins of molecular weights ranging from 22,124 for human growth hormone (HGH to 47,400 for bovine growth hormone. 

Bovine growth hormone, a difficult protein for which to develop controlled release systems due to its propensity toward self-aggregation and inactivation, has successfully been incorporated into polyanhydride matrices (18). The growth hormone was colyophilized with sucrose, dry-mixed with finely powdered polyanhydride, and then compression molded into 1.4-cm-diaraeter wafers, 1 mm thick. As is shown in Fig. 15, release of bovine growth hormone was well controlled over a prolonged period of time. The assay for bovine... 

FIGURE 15 Release of bovine growth hormone from compression-molded discs of PCPH. Details were as described in the text. 

D. N. Brems, Solubility of different folding conformers of bovine growth hormone, Biochemistry, 27, 44541 (1988). 

H. A. Havel, R. S. Chao, R. J. Haskell, and T. J. Thamann. Investigation of protein structure with optical spectroscopy Bovine growth hormone, Anal. Chem., 61, 642 (1989). 

Epstein, S.S. (1990a). Questions and answers on synthetic bovine growth hormones, Int. 

Recombinant bovine growth hormone (bovine somatotropin, BST)... 

While most biopharmaceuticals approved to date are intended for human use, a number of products destined for veterinary application have also come on the market. One early example of this is recombinant bovine growth hormone (somatotrophin), approved in the USA in the early 1990s and used to increase milk yields from dairy cattle. Additional examples of approved veterinary biopharmaceuticals include a range of recombinant vaccines and an interferon-based product (Table 1.9). 

In 1993, the FDA approved the use of recombinant bovine growth hormone (rbGH) in dairy cattle to increase milk production. Although milk and meat from rbGH-treated cows appear to be safe, these cows have a higher incidence of mastitis, which could increase antibiotic use and result in greater antibiotic residues in milk and meat. 

Transgenic bacteria have been developed to mass-produce a variety of valuable proteins, including bovine growth hormone (BGH). When this hormone is injected into dairy or beef cattle, it raises milk production or improves weight gain. It has passed all safety tests so far and is now being used extensively in dairy herds. 

Are you willing to drink milk from a cow whose milk production has been increased by injections of bovine growth hormone Does it matter to you that this bovine growth hormone was created by transgenic bacteria Why or why not ... 

Human growth hormone produced in bacteria is used to help very short children to grow. Bovine growth hormone produced in bacteria is used to increase milk production from cows.43 However, this... 

Chang, J. P Kiehl, D. E. Kennington, A. 1997. Separation and characterization of the tryptic peptide mapping of recombinant bovine growth hormone by reversed-phase high-performance liquid chromatography electrospray mass spectrometry. Rapid Commun. Mass Spectrom., 11, 1266-1270. 

Hormones are not allowed in organic production. This includes the range from the common milk letdown hormone (oxytocin) to lutylase which is used in conventional dairy to induce egg production by the ovary. Also prohibited of course is the use of the controversial growth hormone known as rBGH (recombinant bovine growth hormone). 

Fig. 2.13. Restriction map of the region of the bovine genome containing the gene for bovine growth hormone generated with selected restriction enzymes. The arrow denotes the promoter region and the box represents the protein coding...

Ramabhadran, T.V., Reitz, B.A., and Shah, D.M. (1985). High-level expression of bovine growth hormone gene in heterologous mammalian cells. Gene 38,111 118. 

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