Glucose 1-dehydrogenase

Carboxylic acids with labile a-methylene protons react with isatin in the presence of strong aqueous base. In the total synthesis of methoxatin, the coenzyme of methanol dehydrogenase and glucose dehydrogenase, Weinreb employs a Pfitzinger condensation of an isatin 37 and pyruvic acid as a key step to provide the 4-quinolinic acid 38 in 50% yield under the standard basic conditions. ... 

Figure 17.11 Schematic representation of an approach for achieving efficient electrocatalysis of glucose oxidation by glucose dehydrogenase on Au nanoparticles tethered on an Au electrode. The nanoparticles are modified with a PQQ-capped linker that interacts with the unoccupied PQQ site of cofactor-deficient glucose dehydrogenase [Zayats et al., 2005].

Okuda J, Yamazaki T, Fukasawa M, Kakehi N, Sode K. 2007. The application of engineered glucose dehydrogenase to a direct electron-transfer-type continuous glucose monitoring system and a compartmentless biofuel cell. Anal Lett 40 431 -440. 

Zayats M, Katz E, Baron R, Willner I. 2005. Reconstitution of apo-glucose dehydrogenase on pyrroloquinoline quinone-functionalized Au nanoparticles yields an electrically contacted hiocatalyst. J Am Chem Soc 127 12400-12406. 

Narayanaswamy R., Sevilla F., An optical fiber probe for the determination of glucose based on immobilized glucose dehydrogenase, Anal. Lett. 1988 21 1165. 

E. D Costa, J. Higgins, and A.P. Turner, Quinoprotein glucose dehydrogenase and its application in an amperometric glucose sensor. Biosensors 2, 71—87 (1986). 

M. Yamada, M. Elias, K. Matsushita, C.T. Migita, and O. Adachi, Escherichia coli PQQ-containing quinoprotein glucose dehydrogenase its structure comparison with other quinoproteins. Biochim. Biophys. Acta Proteins Proteomics 1647, 185-192 (2003). 

J. Okuda and K. Sode, PQQ glucose dehydrogenase with novel electron transfer ability. Biochem. Biophys. Res. Commun. 314, 793-797 (2004). 

D-Glucosone is not oxidized by the D-glucose dehydrogenase of liver and does not inhibit the oxidation of D-glucose by this enzyme.98... 

Another type of sensor was based on the utilization of glucose dehydrogenase enzyme coupling with /ra(2,2 -bipyridylruthenium(II) complex [31]. This sensor can be used in the 10-2500-pmol/L concentration range. Several interferences occur, like NADH, oxalate, proline, and tripropylamine. However, gluconic acid and NAD+ do not interfere. 

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