Glucose-6-phosphate dehydrogenase G-6-PD

B22. Beutler, E Kuhl, W., Ramirez, E and Lisker, R., Some Mexican glucose-6-phosphate dehydrogenase (G-6-PD) variants revisited. Hum. Genet. 86,371-374 (1991). 

Monitoring Perform periodic blood cell counts during prolonged therapy. If a severe blood disorder appears, consider discontinuation. Use caution in glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. 

Kay AC, Kuhl W, Prchal J, Beutler E. The origin of glucose-6-phosphate-dehydrogenase (G-6-PD) polymorphisms in African-Americans. Am J Hum Genet 1992 50 394-398. 

Many isoenzymes have been identified from various human tissue sources however, our consideration will deal with six erythrocytic systems that have received routine crime laboratory status. These are phosphoglucomutase (PGM), adenylate kinase (AK), adenosine deaminase (ADA), glucose-6-phosphate dehydrogenase (G-6-PD), 6-phosphogluconate dehydrogenase (6-PGD) and erythrocytic acid phosphatase (EAP). 

It is becoming increasingly evident that a number of adverse reactions to drugs are due to genetically transmitted inborn enzyme abnormalities or deficiencies. The best known example of this category is the hereditary relative deficiency of the enzyme glucose-6-phosphate-dehydrogenase (G-6-PD), which occurs in 5% to 10% of Mediterranean littoral races, blacks, Pakistanis, and Sephardic Jews. This condition renders affected individuals susceptible to acute hemolytic ane-... 

An interesting role of acid phosphatase alleles on an unusual condition in man has recently been reported by Bottini et al. (B27). It has long been appreciated that subjects with erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency may have a severe hemolytic crisis after ingestion of fava beans. Although this deficiency is a necessary condition for the occurrence of hemolytic episodes, not all, indeed only... 

Quinine is contraindicated in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, optic neuritis, tinnitus, or a history of blackwater fever and thrombocytopenia purpura. The symptoms of overdosage are tinnitus, dizziness, skin rash, and GI disturbance (intestinal cramping). With higher doses, cardiovascular and CNS effects may occur, including headache, fever, vomiting, apprehension, confusion, and convulsions. 

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