Glucose dehydrogenase, inhibition

D-Glucosone is not oxidized by the D-glucose dehydrogenase of liver and does not inhibit the oxidation of D-glucose by this enzyme.98... 

Glucose-6-phosphate dehydrogenase inhibition. Petroleum ether extract of the fresh fruit, administered to pigs at a concentration of 3.5 g/kg of diet for 29 days, was active on hepatic enzymes . 

Glucose production Inhibition Pyruvate dehydrogenase (PDH) Stimulation... 

N6. Neufeld, E. F., and Hall, C. W., Inhibition of UDP-n-glucose dehydrogenase by UDP-n-xylose A possible regulatory mechanism. Biochem. Biophys. Res. Common. 19, 456- 61 (1965). 

Huh JW, Choi MM, Yang SJ, Yoon SY, Choi SY, Cho SW. Inhibition of human UDP-glucose dehydrogenase expression using siRNA expression vector in breast cancer cells. Biotechnol Lett 2005 27 1229 1232. 

Iron is also an essential constituent of several non-porphyrin enzymes, e.g. aconitase, aldolase, and succinic dehydrogenase. Inhibition of the synthesis of glucose by tryptophan in animal cells depends on chelation. The tryptophan is metabolized to pyridine-2,3-dicarboxylic acid, which complexes the divalent iron necessary for the action of phosphoenolpyruvate carboxykinase (a key enzyme in the neogenesis of glucose) (Veneziale et al., 1967). 

Guinea pig (a) Inhibition of UDP-glucose dehydrogenase and UDP-glucuronyl transferase in liver and intestine by piperine [14]... 

Both DPNH and TPNH were regenerated in this experiment with glucose and glucose dehydrogenase as hydrogen donor system. Sodium chloride (0.1 M final concentration) was used to demonstrate the inhibition. 

We have emphasized the specific character of macromolecules. Even in the arsenal of enzymes common to all cells we find indications of this specificity. The glucose dehydrogenase of vertebrate liver for example, is not inhibited by toluene, whilst that of E. colt is inhibited. Yeast alcohol dehydrogenase is completely inhibited by O-OOIM iodoacetate, whilst even at a concentration of O-OIM, animal alcohol dehydrogenase remains imaffected. Glutamic add dehydrogenase of yeast requires TPN as a coenzyme whilst the same enzyme from plants needs DPN. 

A property of UDP-glucose dehydrogenase, which is of particular importance for the biosynthesis of pmteoglycans, has been described by Neufeld and Hall (1965) the enzyme is strongly and specificzdly inhibited... 

The rate of mitochondrial oxidations and ATP synthesis is continually adjusted to the needs of the cell (see reviews by Brand and Murphy 1987 Brown, 1992). Physical activity and the nutritional and endocrine states determine which substrates are oxidized by skeletal muscle. Insulin increases the utilization of glucose by promoting its uptake by muscle and by decreasing the availability of free long-chain fatty acids, and of acetoacetate and 3-hydroxybutyrate formed by fatty acid oxidation in the liver, secondary to decreased lipolysis in adipose tissue. Product inhibition of pyruvate dehydrogenase by NADH and acetyl-CoA formed by fatty acid oxidation decreases glucose oxidation in muscle. 

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