Blood glucose-6-phosphate dehydrogenase

B27. Beutler, E., Westwood, B., Melemed, A., Borgo, P. D., and Margolis, D Three new exon 10 glucose-6-phosphate dehydrogenase mutations. Blood Cells Mol. Dis. 21,64-72 (1995). 

B29. Beutler, E Vuliamy, T., and Luzzatto, L., Hematologically important mutations Glucose-6-phosphate dehydrogenase. Blood Cells Mol. Dis. 22, 49-56 (1996). 

C4. Chang, J.-G., Chiou, S.-S., Pemg, L.-I, Chen, T.-C., Liu, T.-C., Lee, L-S., Chen, P-H., and Tang, T. K., Molecular characterization of glucose-6-phosphate dehydrogenase (G6PD) deficiency by natural and amplification created restriction sites Five mutations account for most G6PD deficiency cases in Taiwan. Blood 80,1079-1082 (1992). 

HI 1. Hirono, A., Fujii, H Shima, M and Miwa, S., G6PD Nara Anew class 1 glucose-6-phosphate dehydrogenase variant with an eight amino acid deletion. Blood 82,3250-3252 (1993). 

H13. Hirono, A., Miwa, S., Fujii, H Ishida, F., Yamada, K., and Kubota, K., Molecular study of eight Japanese cases of glucose-6-phosphate dehydrogenase deficiency by non-radioisotopic singlestrand conformation polymorphism (SSCP) analysis. Blood 83,3363-3368 (1994). 

N7. Ninfali, P., Bresolin, N., Baronciani, L., Fortunato, F., Comi, G., Magnani, M., and Scarlato, G., Glucose-6-phosphate dehydrogenase Lodi844C A study on its expression in blood cells and muscle. Enzyme 45, 180-187 (1991). 

X3. Xu, W., Westwood, B., Bartsocas, C. S., Malcorra-Azpiazu, J. J., Indrak, K., and Beutler, E Glucose-6-phosphate dehydrogenase mutations and haplotypes in various ethnic groups. Blood 85,257-263 (1995). 

Cocco PL, Cocco E, Anni MS, et al. 1991. Occupational exposure to lead and blood cholesterol in glucose-6-phosphate dehydrogenase deficient and normal subjects. Res Commun Chem Pathol Pharmacol 72(1) 81-95. 

Primaquine should be administered cautiously to actually ill patients with any serious systemic disease characterized by a tendency to granulocytopenia such as rheumatoid arthritis or lupus erythematosus. The drug should be used with care in patients with glucose-6-phosphate dehydrogenase deficiency. Primaquine should be withdrawn if signs of haemolysis or methaemoglobinaemia occur and the blood... 

Glucose-6-phosphate dehydrogenase (G6PD) deficiency in red blood cells X-linked recessive inheritance many specific mutations Common variants mild deficiency variant in African Americans, moderately severe deficiency variant in Caucasians of Mediterranean descent Frequency 1/10 males 1/100 males, African American and Mediterranean, respectively... 

W22. Wurzel, H., McCreary, T., Baker, L., and Gumerman, L., Glucose-e-phosphate dehydrogenase activity in platelets. Blood 17, 314-318 (1961). 

Anthraquinone glycosides found in senna (Cassia fistulosa) and Aloe spp. have been included in some commercial cathartics. Vicine is a glycoside in fava beans (Vida faba), and causes hemolytic anemia in people who have a genetic deficiency of glucose-6-phosphate dehydrogenase activity in their red blood cells. Fava beans are grown as a protein supplement for livestock. 

TrieffNM, Ficklen D, Gan J. 1993. In vitro inactivation of glucose-6-phosphate dehydrogenase from human red blood cells by acrolein A possible biomarker of exposure. Toxicol Letters 69 121-127. 

In a fatal human exposure, a worker engaged in emptying metal gas cylinders of methyl mercaptan was found comatose at the work site he developed expiratory wheezes, elevated blood pressure, tachycardia, and marked rigidity of extremities. Methemoglobinemia and severe hemolytic anemia developed with hematuria and proteinuria but were brief in duration deep coma persisted until death due to pulmonary embolus 28 days after exposure. It was determined that the individual was deficient in erythrocyte glucose-6-phosphate dehydrogenase, which was the likely cause of the hemolysis and formation of methemoglobin. 

Monitoring Perform periodic blood cell counts during prolonged therapy. If a severe blood disorder appears, consider discontinuation. Use caution in glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. 

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