What Genes Are Related to Glucose-6-Phosphate Dehydrogenase Deficiency

What Genes Are Related to Glucose-6-Phosphate Dehydrogenase Deficiency  

Mutations in the G6PD (http /ghr.nlm.nih.gov/gene=g6pd) gene cause glucose-6- 

Researchers beheve that carriers of a G6PD mutation may be partially protected against malaria, an infectious disease carried by a certain type of mosquito. A reduction in the amount of functional glucose-6-dehydrogenase appears to make it more difficult for this parasite to invade red blood cells. Glucose-6-phosphate dehydrogenase deficiency occurs most frequently in areas of the world where malaria is common. 

This condition is inherited in an X-linked recessive pattern. A condition is considered X-linked if the mutated gene that causes the disorder is located on the X chromosome, one of the two sex chromosomes. In males (who have only one X chromosome), one altered copy of the gene in each cell is sufficient to cause the condition. In females (who have two X chromosomes), a mutation must he present in hoth copies of the gene to cause the disorder. Males are affected hy X-linked recessive disorders much more frequently than females. A striking characteristic of X-linked inheritance is that fathers cannot pass X-hnked traits to their sons. 

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