Genistein

Phytoestrogens Isoflavones genistein ER/1, ERa" 3 Agonist Induces vitellogenin expression,... 

Normal ad libitum diet supplemented with 38 g soya protein/day (38 mg/day genistein) for 6 months Postmenopausal women (n = 6)... 

Infant s food Matrix analysed Age (months) Isoflavone level (ng/ml) Genistein Daidzein Equal... 

Genistin (genistein-7-D-glucoside) [529-59-9] M 432.4, m 256 . Crystd from 80% EtOH/water. 

At least seven other bases have been mentioned as present in the mother liquors from the manufacture of Z-sparteine sulphate. Valeur found two, sarothamnine and genisteine, of which Winterfeld and Nitzsche have confirmed genisteine and have themselves added four more, two, thought to be structural and two, optical isomerides of sparteine, with a fifth substance of higher boiling point. 

A few computational studies focus on the saturated analog of 4//-l,4-oxazine, i.e., morpholine [98JCS(P2)1223, 00JCS(P2)1619, 00TL5077]. These cover the structure of lithium morpholide, cycloaddition reactions, and molecular complexes with genistein. 

Genistein Daidzen Glycitein IVP-Estradiol MCE-7 Custom Genistein 10 xM Daidzen 10 xM Glycitein 10 xM 17P-Estradiol 10 nM Gene name. Accession number, fold change in table 118... 

Inhibition of steroid sulphatase and sulphotransferase Steroid sulphotransferase catalyses the addition of sulphate to steroidal compounds whilst steroid sulphatase catalyses the reverse reaction. In vitro studies have demonstrated that a metabolite of genistein, 4-ethylphenol, can inhibit sulphotransferase (Harris et al, 2000). Sulphoconjugates of daidzein have also been found to potently inhibit these enzymes in vitro (Wong and... 

Genistein, a specific inhibitor of tyrosine-specific protein kinases. JBiol Chem. 262 5592-5. 

ATLURU s, ATLURU D (1991) Evidence that genistein, a protein-tyrosine kinase inhibitor, inhibits CD28 monoclonal antibody stimulated human T-cell proliferation. Transplantation. 51 448-50. 

CHANG H 0, CHURCHWELL M I, DELCLOS K B, NEWBOLD, DOERGE D R (2000) Mass spectrometric determination of genistein tissue distribution in diet-exposed Sprague-Dawley rats. J Nutr. 130 1963-70. 

CONSTANTINOU A, HUBERMAN E (1995) Genistein as an inducer of tumour cell differentiation possible mechanisms of action. Proc Soc Exp Biol Med. 208 109-15. 

FABER K A, HUGHES c L JR. (1993) Dose-responsive characteristics of neonatal exposure to genistein on pituitary responsiveness to gonadotrophin releasing hormone and volume of the sexually dimorphic nucleus of the preoptic area (SDN-POA) in postpubertal castrated female rats. Reprod Toxicol. 1 35-9. 

The phytoestrogen genistein reduced bone loss in short-term ovariectomised rats. Osteoporosis Int. 8 274-81. 

FLYNN K M, FERGUSON s A, DELCLOS K B, NEWBOLD R R (2000) Effects of genistein exposure on sexually diamorphic behaviors in rats. Toxicol Sci. 55 311-19. 

HSIEH c Y, SANTELL R c, HASLAM s z, HELFERICH w G (1998) Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Res. 58 3883-3838. 

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