Genistein derivatives

Lee MS, Kim CH, Hoang DM, Kim BY, Sohn CB, Kim MR, Ahn JS. (2009) Genistein-derivatives from Tetracera scandens stimulate glucose-uptake in L6 myotubes. Biol Pharm Bull 32 504-508. 

Kaamanen, M., Adlercreutz, H., Jauhiainen, M., and Tikkanen, M.J., Accumulation of genistein and lipophilic genistein derivatives in lipoproteins during incubation with human plasma in vitro, Biochim. Biophys. Acta, 1631, 147, 2003. 

Cao et al. [85] examined the antitumor effects of 7-difluoromethoxyl-5,4 -di-n-octylgenistein (DFCXj), a novel synthetic genistein derivative, on human ovarian cancer cells as well as the molecular mechanism (Fig. 16). 

OITATE M, NAKAKI R, KOYABU N, TAKANAGA H, MATSUO H, OHTANI H, SAWADA Y (2001) TranSCellular transport of genistein, a soybean-derived isoflavone, across human colon carcinoma cell line (Caco-2). Biopharm Drug Dispos. 22 23-9. 

KAPIOTIS S, HERMAN M, HELD I, SEELOS C, EHRINGER H, GMEINER B M, (1997) Genistein, the dietary-derived angiogenesis inhibitor, prevents LDL oxidation and protects endothelial... 

Dean, N.M., Kanemitsu, M. and Boynton, A.L. (1989) Effects of the tyrosine-kinase inhibitor genistein on DNA synthesis and phospholipid-derived second messenger generation in mouse lOTl/2 fibroblasts and rat liver T51B cells. Biochemical and Biophysical Research Communications, 165, 795-801. 

Protein Kinase Inhibitors Pseudosubstrate-based peptide inhibitors, 201, 287 utilization of the inhibitor protein of adenosine cyclic monophosphate-dependent protein kinase, and peptides derived from it, as tools to study adenosine cyclic monophosphate-mediated cellular processes, 201, 304 use of sphingosine as inhibitor of protein kinase C, 201, 316 properties and use of H-series compounds as protein kinase inhibitors, 201, 328 use and specificity of staurosporine, UCN-01, and calphostin C as protein kinase inhibitors, 201, 340 inhibition of protein-tyrosine kinases by tyrphostins, 201, 347 use and specificity of genistein as inhibitor of protein-tyrosine kinases, 201, 362 use and selectivity of herbimycin a as inhibitor of protein-tyrosine kinases,... 

Isoflavonoids include the isoflavones genistein and daidzein, which occur mainly as the glycosides genistin and daidzin (see Figure 7.2), respectively, in soybeans and consequently in a wide range of soy-derived foods and to a lesser extent in other legumes. Traditional... 

This increased resistance of LDL to oxidation is in agreement with the findings of a number of studies with dietary soy, including the increase in lag time in a study in six young healthy male and female subjects who consumed three soy bars per day (providing 57 mg total isoflavones/day 36 mg genistein and 21 mg daidzein) for 2 weeks.Although HDL-derived 17(3-estradiol fatty acid esters have been shown to accumulate in LDL ex v/vo and esterified... 

Fotsis T, Pepper M, Adlercreutz H et al. Genistein, a dietary-derived inhibitor of in vitro angiogenesis. Proc. Natl Acad. ScL USA 90, 2690-2694, 1993. 

Glycine max (L.) Merrill G. soja Sieb. Zucc. Da Dou Ye Da Dou (Soybean) (seed) Protein, isoflavone derivatives, genisteine, daidzein, riboflavin, thiamine, niacin, pantothenic acid, choline.33,67 Phytoestrogenic, elevate the vasomotor system, prevent cancer, a potent inhibitor of protein tyrosine kinase. 

Isoflavone derivatives along with nonvolatile components in soy sauce were also analyzed by gradient reversed-phase HPLC. This HPLC profile of soy sauce was further utilized by a pattern recognition program to understand the quality differences of soy sauces (132), and three isoflavone derivatives (esters of tartaric acid with daidzein, genistein, and 8-hydroxygenistein) were found to contribute significantly to the differentiation in fermented soy sauce. Fermented... 

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