Genistein sources

Anderson et al., 1998 OVX, lactating rats low calcium diet genistein-rich protein source 3 doses isoflavones (0.5, 1.6, 5.0 mg/d) for 2 weeks A biphasic response to genistein was observed for bone weight (femur ash) low dose more protective than high dose... 

Kaufman, P.B., Duke, J.A., Brielmann, H., Boik, J., and Hoyt, J.E. 1997. A comprehensive survey of leguminous plants as sources of the isoflavones, genistein and daidzein implications for human nutrition and health. J. Alternate Complementary Med. 3 7-22. 

Fermented soy such as tempeh, miso, and tamari are healthy sources of both genistein and daidzein. Soy also contains two other antitumor compounds beta-sitosterol and Bowman-Birk inhibitor. 

Lima beans are a rich source of genistein. Other beans and peas (especially sprouted beans), black beans, and black-eyed peas also contain this isoflavone. 

Red clover (Trifolium pratense) is a rich source of genistein and daidzein as well as two other important phytosterols, biochanin and formononetin. It has traditionally been used as an alterative, as a lymph and liver tonic, and to prevent and to treat various cancers. 

The two major sources that contribute to a rise in [Ca2+]j are the release of intracellular Ca + from the SR and the influx of extracellular Ca + (van Breemen and Saida, 1989 Tsien and Tsien, 1990 Missiaen et al., 1992 Pozzan et al., 1994). Therefore, two important questions are (1) does genistein-sensitive tyrosine kinase activity participate in regulatory mechanisms that couple receptor activation and release of intracellular Ca +, and (2) does tyrosine kinase activity participate in mechanisms that couple receptor activation to influx of extracellular Ca2+ To address these questions, we studied the effects of genistein on the Ca + response evoked by AVP or Et in the presence or absence of extracellular Ca2+. Ca + responses elicited in the absence of extracellular Ca + (0.5 mM EGTA and no added Ca +) purportedly reflect release of intracellular Ca2+ from vesicular storage sites such as the SR. Therefore, as amply documented in many studies, comparison of Ca + response elicited in the presence and absence of extracellular Ca + allows for assessment of the relative contribution of influx and release pathways to the evoked change in [Ca +Jj. 

Isoflavones are mainly found in legumes and particularly in soy. Soy is the major source of genistein and daizdein, although their presence has also been reported in black beans, green split peas, and clover sprouts. The widespread use of soy products in infant foods, vegetarian formulations and as an ingredient in the composition of several foods leads to its ubiquitous presence in foodstuffs. Other isoflavones with nutritional relevance are brochamin and formononetin, which occur in... 

Note 86 university students (54 females and 32 males) ate 2 g/body weight of unprocessed, boiled, natural soybeans for seven consecutive days. Actual serum levels of daidzein and genistein, TSH free thyroid hormones, and autoantibodies to thyroid peroxidase and thyroglobulin were measured before, at the end, and 7 days after controlled soy consumption. The table provides an extract from Pearson s correlation matrices. Data from significant correlations (p < 0.05) in at least one subgroup of subjects in at least one stage of the experiment. NS means not significant other symbols are the same as in the previous tables. Source Reproduced from HampI eta/. (2007). 

Isoflavones are found almost exclusively in leguminous plants. Legumes, particularly soybean (Glycine max L.) and its processed products, are the richest sources of isoflavones mainly genistein, daidzein, and glycitein, in the human diet." Recently soy isoflavones have been reported also in 2-3... 

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