Sexually dimorphic nucleus

Phytoestrogens have also been shown to have behavioural effects in rodents including increases in sexual activity (Patisaul et al, 2001) and a reversal of sex-specific behaviours (Lund et al, 2001 Flynn et al, 2000). In rodents, the sexually dimorphic nucleus of the preoptic area (SDN-POA) is located in the hypothalamic region of the brain. This area of the brain controls... 

FABER K A, HUGHES c L JR. (1993) Dose-responsive characteristics of neonatal exposure to genistein on pituitary responsiveness to gonadotrophin releasing hormone and volume of the sexually dimorphic nucleus of the preoptic area (SDN-POA) in postpubertal castrated female rats. Reprod Toxicol. 1 35-9. 

Davis, E.C., Shryne, J.E., and Gorski, R.A. (1996) Structural sexual dimorphisms in the anteroventral periventricular nucleus of the rat hypothalamus are sensitive to gonadal steroids postnatally, but develop perlpubertally. Neuroendocrinology 63 142-148. 

Simerly RB, Swanson LW, Gorski RA (1985a) The distribution of monoaminergic cells and fibers in a periventricular preoptic nucleus involved in the control of gonadotropin release immunohistochemical evidence for a dopaminergic sexual dimorphism. Brain Res 330 55-64. 

Simerly RB, Swanson LW, Handa RJ, Gorski RA (1985b) Influence of perinatal androgen on the sexually dimorphic distribution of tyrosine hydroxylase-immunoreactive cells and fibers in the anteroventral periventricular nucleus of the rat. Neuroendocrinol 40 501-510. 

Hines, M., Davis, F. C., Coquelin, A., Goy, R. W., and Gorski, R. A., 1985, Sexually dimorphic regions in the medial preoptic area and the bed nucleus of the stria terminalis of the guinea pig brain A description and an investigation of their relationship to gonadal steroids in adulthood, J. Neurosci. 5 41 -47. 

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