Genistein toxicity

Fritz, W, Wang, J, Coward L, Lamartiniere CA. Dietary genistein perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat. Carcinogenesis 19, 2151-2158, 1998. 

Okazaki K, Okazaki S, Nakamura H, Kitamura Y, Hatayama K, Wakabayashi S, Tsuda T, Katsumata T, Nishikawa A, Hi-rose M (2002) A repeated 28-day oral dose toxicity study of genistein in rats, based on the Enhanced OECD Test Guideline 407 for screening endocrine-disrupting chemicals. Arch Toxicol 76 553-559 Sandow J (1979) Toxicological evaluation of drugs affecting the hypothalamic-pituitary system. Pharmac Ther 5 297-303... 

Genistein and daidzein directly affect testosterone metabolism, reducing the toxic metabolites of testosterone. Genistein, an isoflavone, also seems to slow or prevent the metastasis of invasive cancer cells. It is believed to work by preventing the formation of new blood vessels to cancerous tumors. Histoculture studies of genistein have shown that this phytochemical reduces the growth of prostatic cancer tissue. 

Popiolkiewicz J, Polkowski K, Skierski JS, Mazurek AP (2005) In vitro toxicity evaluation in the development of new anticancer drugs-genistein glycosides. Cancer Lett 229 67-75... 

NCT01489813 Phase II randomized placebo-controlled clinical trial of genistein in reducing the toxicity and improving the efficacy of intravesical therapy... 

A few examples are found of the toxicity of some of the phenolics to livestock. The phenol ether, tremetone, from Eupatorium rugosum, caused toxic effects in livestock as did the isoflavones, genistein, and coumestrol (93). 

NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of genis-tein, April, NTP-CERHR-Genistein-06, http /cerhr.niehs.nih.gov, 2006. 

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