Isoflavones genistein

Phytoestrogens Isoflavones genistein ER/1, ERa" 3 Agonist Induces vitellogenin expression,... 

An inverse correlation between thyroid cancer risk and phytoestrogens was recently proposed as a result of a multi-ethnic population-based case control study conducted in the San Francisco Bay Area (Hom-Ross et al., 2002). In this study, dietary habits and phytoestrogen consumption were assessed by a food-frequency questionnaire and by a nutrient database. The outcome of the study was that soy-based foods and alfalfa sprouts were associated with a reduction of thyroid cancer risk, whereas a Western diet did not influence cancer risk. No difference was observed between American and Asian women or between pre- and postmenopausal women. Furthermore, among the few compounds examined, the isoflavones genistein and daidzein and the lignan secoisolariciresinol were the phytoestrogens most frequently associated with risk reduction (Horn-Ross et al., 2002). 

KERRY N and ABBEY M (1998) The isoflavone genistein inhibits copper and peroxyl radical mediated low density lipoprotein oxidation in vitro. Atherosclerosis. 140 (2) 341-7. 

KIM H, PETERSON T G and BARNES s (1998) Mechanism of action of the soy isoflavone genistein emerging role for its effects via transforming growth factor 3 signalling pathways. J Clin Nutr. 68 (6 Suppl) 1418S-1425S. 

WEI H, CAO Q AND RAHN R o (1996) Inhibition of UV light- and Fenton reaction-induced oxidative DNA damage by the soybean isoflavone genistein. Carcinogenesis. 17 (1) 73-7. 

YU o, JUNG w, SHI J, CROES R A, FADER G M, MCGONIGLE B and ODELL J T (2000) Production of the isoflavones genistein and daidzein in non-legume dicot and monocot tissues. Plant Physiol. 124 (2) 781-94. 

Isoflavones Genistein Soya bean 64.8 US Department of Agriculture 2007b... 

Doerge D.R., Churchwell M.I., and Delclos K.B., 2000. Online sample preparation using restricted-access media in the analysis of the soy isoflavones, genistein and daidzein, in rat serum using liquid chromatography electrospray mass spectrometry. Rapid Commun Mass Spectrom 14 673. 

Genistein (116) Isoflavone Genistein (116) Oncology (antitumor) Protein-tyrosine kinase inhibition, antioxidative Phase I/II Astellas, Bausch Lomb 708... 

Hong H, Landaver MR, Foriska MA, Ledney GD (2006) Antibacterial activity of the soy isoflavone genistein. J Basic Microbiol 46 329-335. 

Isoflavonoids include the isoflavones genistein and daidzein, which occur mainly as the glycosides genistin and daidzin (see Figure 7.2), respectively, in soybeans and consequently in a wide range of soy-derived foods and to a lesser extent in other legumes. Traditional... 

Fanti P, Sawaya PB, Custer LJ, Franke AA. 1999. Serum levels and metabolic clearance of the isoflavones genistein and daidzein in hemodialysis patients. J Am Soc Nephrol... 

Sfakianos J, Coward L, Kirk M, Barnes S. 1997. Intestinal uptake and biliary excretion of the isoflavone genistein in the rat Evidence for its enterohepatic circulation. J Nutr 127 1260-1268. 

The molecular mechanisms by which estrogens and the isoflavones genistein, daidzein, and equol up-regulate antioxidant gene expression in different... 

---