Gamma production

SMA-NCS can also be used to activate macrophages, natural cells, and T cells and to induce interferon-gamma production [265]. 

Bohn, E. and Autenrieth, I.B., IL-12 is essential for resistance against Yersinia enteroco-litica by triggering IFN-gamma production in NK cells and CD4+ T cells, J. Immunol., 156, 1458, 1996. 

Leonard, J.R et al., Effects of single-dose interleukin-12 exposure on interleukin-12-as-sociated toxicity and interferon-gamma production, Blood, 90, 2541, 1997. 

Sanders, M.E.. et al., Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, andLFA-1) and three other molecules(UCHLl, CDw29, Pgp-1) and have enhanced IFN-gamma production, J. Immunol, 140, 1401, 1988. 

Stern DA, Guerra S, Halonen M, et al Low IFN-gamma production in the first year of life as a predictor of wheeze during childhood. J Allergy Clin Immunol 2007 120 835-841. 

P. W. Schmor, L. Buchtnann, An H+ Ion Source for Resonant Gamma Production, Proceedings of the First International Symposium on Explosive Detection Technology, 13—15 November 1991, S. M. Khan (ed.), Feburary 1992. 

Asherson GL, Dieli F. 1992. Immune deviation in the mouse transfer of selective depression of contact sensitivity and interleukin-2 response with retension of interferon-gamma production requires CD8+ T cells. Immunology 76 427-432. 

Hasko G, Nemeth ZH, Vizi ES, Salzman AL, Szabo C (1998) An agonist of adenosine A3 receptors decreases interleukin-12 and interferon-gamma production and prevents lethality in endo-toxemic mice. Eur J Pharmacol 358(3) 261—268... 

Chace,J.H., Hooker, N.A., Mildenstein, K.L., Krieg, A.M. and Cowdery,J.S. (1997) Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12. Clin. Immunol. Immunopathol., 84, 185-193. 

Iho, S., Yamamoto, T., Takahashi, T. and Yamamoto, S. (1999) Oligodeoxynucleotides containing palindrome sequences with internal 5-CpG-i act directly on human NK and activated T cells to induce IFN-gamma production in vitro. J. Immunol., 163, 3642-3652. 

Ballez JS, Mols J, Burteau CC, Agathos SN, Schneider YJ (2004), Plant protein hydrolysates support CHO-320 cells proliferation and recombinant interferon-gamma production in suspension and inside microcarriers in protein-free media, Cytotechnology 44 103-114. 

Fox SR, Patel UA, Yap MG, Wang DI (2004), Maximizing interferon-gamma production by Chinese hamster ovary cells through temperature shift optimization experimental and modeling, Biotechnol. Bioeng. 85 177-184. 

Yoshimoto, T., Takeda, K., Tanaka, T. et al. 1998. IL-12 up-regulates IL-18 receptor expression on T cells, Thl cells, and B cells Synergism with IL-18 for IFN-gamma production. J Immunol 161 3400-3407. 

Fig. 4. Cross-sections for inelastic neutron gamma production for various lines in nitrogen, oxygen and carbon.

Fantuzzi G, Puren AJ, Harding MW, Livingston DJ, Dinarello CA. Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1 beta-converting enzyme (caspase-l)-deficient mice. Blood 1998 91 2118-2125. 

Halpern MD, Kurlander RJ, Pisetsky DS. Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha. Cell Immunol 1996 167 72-8. 

Petereit HE, Richter N, Pukrop R, Bamborschke S (2000) Interferon gamma production in blood lymphocytes correlates with disability score in multiple sclerosis patients. Mult Scler 6 19—23. 

IL-2 is a lymphokine produced by activated helper T-lympho-cytes. It induces the proliferation of T cells and promotes the differentiation of lymphocytes into cytotoxic cells. IL-2 also induces interferon gamma production (Lewko and Oldham, 2003). Activation of peripheral leukocytes with the drug produces lymphokine-activated killer cells (LAK) that lyse a variety of tumor cells in vitro. IL-2 has been cloned in bacteria through recombinant DNA technology, thus allowing the production of large amounts. IL-2 alone or with LAK cells can cause regression of several established metastatic tumors in animals (Lewko and Oldham, 2003 Dorr, 1993). 

Immune responses can be divided into type 1 and type 2, based on the pattern of cytokine secretion and functional outcome of the immune response. Type 1 immune responses are characterized by secretion of IFN-gamma, production of IgG2a in mice, and activation of macrophages, NK cells, and cytotoxic T-cells. Type 2 responses are characterized by secretion of IL-4, IL-5, and IL-13 and by IgGl and IgE production. The responses are reciprocally regulated. How the polarization of the immune response toward type 1 or type 2 is determined is not exactly understood. IL-12 is an important factor that drives the type 1 response, and IL-4 is implicated in the type 2 response. Microbial products such as LPS and bacterial DNA stimulate the secretion of IL-12 by dendritic cells and preferentially induce type 1 immune responses. 

Koga T, Kubota Y, Nakayama J. Interferon-gamma production in the peripheral lymphocytes of a patient with carbamazepine hypersensitivity syndrome. Acta Dermatol Venereol 2000 80(1) 73. 

Muscettola, M. and Grasso, G. (1990). Neuropeptide modulation of interferon gamma production. Int. J. Neurosci. 51, 189-191. 

Van der Meide PH, De Labie MC, Botman CA, et al. 1993. Mercuric chloride down-regulates T cell interferon-gamma production in Brown Norway but not in Lewis rats Role of glutathione. Eur J Immunol 23(3) 675-681. 

Interleukin-12 restores interferon-gamma production and cytotoxic responses in visceral leishmaniasis. J Infect Dis 1996 173 1515-8. 

Heufler C, Koch F, Stand U, et al. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immune 1996 26 659-68. 

Micallef MJ, Ohtsuki T, Kohno K, et al. Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells synergism with interleukin-12 for interferon-gamma production. Eur J Immuno 1996 26 1647-51,... 

Mytar B, Woloszyn M, Ruggiero I, et al. Monocyte-mediated regulation of antigen-driven IFN gamma production by T cells. The role of endogenously produced TNF. Immuno Invest 1995 24 897-906. 

Munakata T, Semba U, Shibuya Y, et al Induction of Interferon-gamma Production by Human Natural Killer Cells Stimulated by Hydrogen Peroxide. J. Immunol. 1985 134(4) 2449-2455. 

Warner JA, Miles EA, Jones AC, Quint DJ, Colwell BM, Warner JO Is deficiency of interferon gamma production by allergen triggered cord blood cells a predictor of atopic eczema Clin Exp Allergy 1994 24 423 30. 

Tang M, Kemp A, Varigos G lL-4 and interferon-gamma production in children with atopic disease. Clin Exp Immunol 1993 92 120-124. 

Martinez FD, Stem DA, Wright AL, Holberg GJ, Taussig LM, Halonen M Association of interleukin-2 and interferon gamma production by blood mononuclear cells in infancy with parental allergy skin tests and with subsequent development of atopy. J Allergy Clin Immunol 1995 96 652-660. (Ib)... 

FheCL was capable of suppressing IFN- gamma production during Bordetella pertussis infection. 

O Neill SM, Mills KH, Dalton JP (2001) Fasciola hepatica cathepsin L cysteine proteinase suppresses Bordetella pertussis-specific interferon-gamma production in vivo. Parasite Immunol 23(10) 541-547... 

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