Reciprocal regulation

Glycogen Synthase Phosphorylase Activity Are Reciprocally Regulated (Figure 18-7)... 

Snapper, C.M. and Paul, W.E. (1987) Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236, 944-947. 

FIG. 5. Only non-capacitative Ca2+ entry occurs during receptor activation. Cells were stimulated with vasopressin (30 nM for 300 s) under conditions where both, neither or only one of the Ca2+ entry pathways were blocked. The same scale applies to all four traces, with the origin shown on each by a thick line. (Results taken from Moneer Taylor [2002].) The cartoon indicates that reciprocal regulation of the two pathways may allow rapid switching between stimulation (contraction evoked by Ca2+ entering via NCCE) and recovery (relaxation evoked by Ca2+ entering via CCE)... 

Control of pymvate dehydrogenase activity is via covalent modification a specific kinase causes inactivation of the PDH by phosphorylation of three serine residues located in the pyruvate decarboxylase/dehydrogenase component whilst a phosphatase activates PDH by removing the phosphates. The kinase and phosphatase enzymes are non-covalently associated with the transacetylase unit of the complex. Here again we have an example of simultaneous but opposite control of enzyme activity, that is, reciprocal regulation. 

J. Muller, J. J. Windle, R. G. Pestell, and M. P. Lisanti. Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer. J. Biol. Chem. 273 20448-20455... 

Alabadi D, Oyama T, Yanovsky MJ, Harmon FG, Mas P, Kay SA 2001 Reciprocal regulation between TOCl and LHY/CCAl within Arahidopsis circadian clock. Science 293 880-883 Berson DM, Dunn FA, Takao M 2002 Phototransduction by retinal ganglion cells that set the circadian clock. Science 295 1070—1073... 

Hermiston ML et al Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases. J Clin Invest 2002 109 9. [PMID 11781344]... 

Glycolysis and gluconeogenesis are reciprocally regulated to prevent wasteful operation of both pathways at the same time. 

Zhong H, Yokoyama CT, Scheuer T, Catterall WA (1999) Reciprocal regulation of P/Q-type Ca2+ channels by SNAP-25, syntaxin and synaptotagmin. Nat Neurosci 2 939 41... 

Duffy, H. S., John, G. R., Lee, S. C., Brosnan, C. F., and Spray, D. C. (2000). Reciprocal regulation of the junctional proteins claudin-1 and connexin43 by interleukin-1 beta in primary human fetal astrocytes. J. Neurosci. 20, RC114. 

Figure 1.5. Reciprocal regulation of Ij.-OHase and 24-OHase by parathyroid hormone and I.25-( OH) D3 and organization of the mitochondrial P-450 complex.

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