Extremely toxic substances, list

Carcinogenesis Bioassay (feed) No Evidence mouse, rat NCITR NCI-CG-TR-4,77. Reported in EPA TSCA Inventor c EPA Genetic Toxicology Program. EPA Extremely Hazardous Substances List. SAFETY PROFILE A deadly human poison. Poison by ingesdon, skin contact, intraperitoneal, and subcutaneous routes. Moderately toxic by intravenous route. Human systemic effects coma, dyspnea. 

CONSENSUS REPORTS lARC Cancer Review Group 3 IMEMDT 7,56,87 Animal Sufficient Evidence IMEMDT 12,209,76. Reported in EPA TSCA Inventor). EPA Extremely Hazardous Substances List. SAFETY PROFILE Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic and teratogenic data. Mutation data reported. When heated to decomposition it emits ver) toxic fumes of NOx and HCl. 

Lustrous monoclinic crystals Krebs, Angew. Chem. Int. Ed. 8, 146 (1969) idem, Z. Anorg. Altgem. Chem. 378, 263 (1970). Tetrahedral symmetry in gas phase with the Zr-CI distance of 2.33 A. Extremely hygroscopic, forms HCI vapor and gives off fumes in moist air. d 2.803. Sublimes at 331s. mp 43T under its own pressure which is about 25 atm at this temp. Decomposed by water to form ZrOCIj and HCI sol in alcohol, ether. LDM in mice, rats 655, 1688 mg /kg orally, Toxic Substances List, H. E. Christensen. Ed. (1972) p. 547. 

Exhibits acute, delayed, and chronic toxicity moderately toxic by intraperitoneal route low to moderately toxic by ingestion—LD50 values showing wide variation with species the data reported appear to be questionable highly toxic in dog but low oral toxicity in rat toxic effects in humans unknown but expected to be similar to other urea derivatives susceptible to formation of dimethylnitrosamine under certain conditions, which is carcinogenic EPA-listed extremely toxic substance (U.S. EPA 1989). 

PCB stands for polychlorinated biphenyl. This is found in electrical transformers and components. It is used for insulating and as a heat exchange fluid and hydraulic fluid. It is on the EPA Extremely Hazardous Substances List. It is a confirmed cancer-causing chemical that is toxic and can cause severe liver damage. It has also been linked to behavioral problems in children. 

Precautions Deadly poison by swallowing or skin contact. Human mutagen (changes inherited characteristics). In 1985 over 150 people in California exhibited toxic effects from eating watermelons contaminated with aldicarb. FDA permits limited use. On EPA Extremely Hazardous Substances list. 

Precautions A human poison. Mildly toxic to humans by breathing fumes. A corrosive irritant to the skin, eyes, nose, and throats. A concentration of 35 ppm causes irritation of the throat after short exposure. On EPA Extremely Hazardous Substance list. 

Precautions On EPA Extremely Hazardous Substance list. A confirmed carcinogen (causes cancer). Moderately toxic by swallowing. Causes skin irritation. Exposed persons may suffer nausea, vomiting, weight loss, jaundice (yellow color-... 

For the exclusive purposes of this review process, the Industrial Chemistry Branch (ICB) of OPPT has developed a short list of extremely toxic substances, for which there is concern at very low levels. This list is found in Table I. This list is subject to change as additional data become available. 

Properties Amber liq. mild odor sol. in most org. soivs. si. sol. in water m.w. 359.58 Toxicology LD50 (oral, rat) 9.66 mg/kg, (IV, rat) 6.6 mg/kg, (dermal, rat) 30-108 mg/kg poison by ing., skin contact, IP, subcut. and IV routes human blood system effects by skin contact a cholinesterase inhibitor Environmental Toxic to fish Precaution EPA extremely hazardous substances list corrosive to metal Hazardous Decomp. Prods. Heated to decomp., emits very toxic fumes of Cl" and POx Uses Insecticide, acaricide, nematicide, parasiticide... 

Synonyms 3- [4-(4-Chlorophenoxy) phenyl]-1,1-dimethylurea 3-(p-(p-Chlorophenoxy) phenyl)-1,1-dimethylurea Empirical C15H16CIN2O2 Properties Cryst m.w. 290.77 Toxicology LD50 (oral, rat) 3700 mg/kg, (skin, rat) > 3 g/kg LC50 (inh., rat, 6 h) > 1350 mg/m mod. toxic by ing. mutagen TSCA listed Environmental Nontoxic to fish Precaution EPA extremely hazardous substances list... 

OSHA relied on several established lists-including the New Jersey Toxic Catastrophe Prevention Act (TCPA), the Delaware Extremely Hazardous Substances Risk Management Act, the European Communities Seveso Directive (82/501/EEC), and NFPA Hazardous Chemicals Data (NFPA 49)-to develop its list of highly hazardous chemicals. OSHA chose to list the chemicals classified as reactive category 3 or 4 in NFPA 49 (1975 edition). 

In Delaware, the Regulation for the Management of Extremely Hazardous Substances Act, developed in response to the Bhopal disaster and several chemical-release incidents in Delaware, became effective in 1989 (27,28). The regulations list 88 toxic substances, 32 flammable substances, and 50 explosive substances. A sufficient quantity is specified for each of these materials, based on potential for a catastrophic event at a distance of 100 m from a... 

An extremely hazardous substance is any agent that may or may not be listed by any government agency which, as the result of short-term exposures associated with releases to the air, cause death, injury, or property damage due to its toxicity, reactivity, flammability, volatility, or corrosivity. 

Highly toxic by ingestion and moderately toxic by inhalation and skin absorption cholinesterase inhibitor exhibits acute, delayed, and chronic toxicity toxic effects are those of organophosphorus pesticides and carbamate esters the symptoms include excessive salivation, lacrimation, blurred vision, headache, labored breathing, twitches of muscle, loss of reflexes, headache, weakness, sweating, nausea, giddiness, vomiting, cramps, diarrhea, convulsions, and coma U.S. EPA-listed extremely hazardous substance. 

Highly toxic exhibits acute, delayed, and chronic toxicity symptoms include nausea, vomiting, weakness, somnolence, excitement, and muscle contraction causes dermatitis and irritation on skin contact a stimulant to central nervous system, producing convulsions can cause adverse reproductive effects no evidence of carcinogenicity in rats and mice oral LD50 value (mice) 7.5 mg/kg exposure limit PEL/TLV-TWA (skin) 0.1 mg/m (OSHA ACGlH) RCRA Waste Number P050 US EPA listed extremely hazardous substance. 

Many organophosphates are highly toxic. The degree of their toxicity, however, may vary. Some of these compounds are listed by the U.S. ERA as priority pollutants. A few of these are also classified as extremely hazardous substances because of their high toxicity. 

Properties Wh. powd. odorless insol. in water, oxygenated and aromatic soivs. m.w. 959.22 dens. 3.00 m.p. 300-310 C Toxicology LD50 (oral, rat) > 5000 kg/kg, (dermal, rabbit) > 2000 mg/kg extremely hazardous substance experimental neoplastigen, teratogenic and reproductive effects questionable carcinogen TSCA listed Hazardous Decomp. Prods. Heated to decomp., emits toxic fumes of Br ... 

Table 1, compiled predominately from the Jieg/.rtry of Toxic Effects of Chemical Substances database [Canadian Centre for Occupational Health and Safety (CCOHS), 2004], summarizes some LDjqs for various compounds and species exposed via different routes, with the most. sensitive (lowest LDjo) species and route listed accordingly. The LD50, of course, depends on the compound in question, as is illustrated for rats exposed orally to 10 different compounds. It is generally accepted that birds are extremely... 

Toxicology Toxic by inh., Ing., skin contact corrosive causes burns TSCA listed Precaution Highly flamm. ignites spontaneously in air burns with blue flame, giving off peculiar, garlic-like odor reacts violently with water contact with water liberates extremely flamm. gases Hazardous Decomp. Prods. Air- and moisture-sensitive handle and store under nitrogen store in cool, dry, well-ventilated area away from incompat. substances (water)... 

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