Estrogen receptor alpha

Sumida, K., Ooe, N., Saito, K., and Kaneko, H. (2003). Limited species differences in estrogen receptor alpha-medicated reporter gene transactivation hy xenoestrogens. Journal of Steroid Biochemistry and Molecular Biology 84, 33 40. 

SAUNDERS P T, MILLAR M R, WILLIAMS K, MACPHERSON S, HARKISS D ANDERSON R A, ORR B, GROOME N p, scoBiE G, FRASER H M (2000) Differential expression of estrogen receptor alpha and beta and androgen recepto in the ovaries of marmosets and humans. Biol Reprod. 63 1088-95. 

Pillon A, Boussioux AM, Escande A, Ait-Aissa S, Gomez E, Fenet H, Ruff M, Moras D, Vignon F, Duchesne MJ, Casellas C, Nicolas JC, Balaguer P (2005) Binding of estrogenic compounds to recombinant estrogen receptor-alpha application to environmental analysis. Environ Health Perspect 113 278-284... 

Couse JF, Hewitt SC, Bunch DO, Sar M, Walker VR, Davies BJ, Korack K (1999a) Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta. Science 286 2328... 

Kim HP, Lee JY, Jeong JK, Bae SW, Lee HK, Jo I (1999) Nongenomic stimulation of nitric oxide release by estrogen is mediated by estrogen receptor alpha localized in caveolae. Biochem Biophys Res Commun 263(l) 257-262... 

Dupont S, Krust A, Gansmuller A, Dierich A, Chambon P, Mark M (2000) Effect of single and compound knockouts of estrogen receptors alpha (ERa) and ( > (FR/f) on muse reproductive phenotypes. Development 127 4277-4291... 

Wijayaratne AL, McDonnell DP (2001) The human estrogen receptor-alpha is a ubiq-uitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. J Biol Chem 276 35684-35692... 

Hodgin JB, Krege JH, Reddick RL, Korach KS, Smithies O, Maeda N (2001) Estrogen receptor alpha is a major mediator of 17beta-estradiol s atheroprotective effects on lesion size in Apoe-/- mice. J Clin Invest 107 333-340... 

Li L, Haynes MP, Bender JR (2003) Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells. Proc Natl Acad Sci USA 100 4807-4812... 

This section summarizes the current information about different human keratins, their functional significance, cell-type-specific distribution as well as their coexpression with myoepithelial markers and estrogen receptor alpha (ER), because these markers exhibit characteristic expression patterns in some human breast tumors. In many of these cases, a definite diagnosis can be achieved only when additional information is provided by immunohistochemistry. 

As regards malignant tumors, K8 and K18 (and also K7 and K19) are expressed in most breast carcinomas (breast carcinomas of luminal phenotype luminal-type breast carcinomas) as the only keratins. Most of these tumors express estrogen receptor alpha and comprise about 90% of all cases of breast cancer most breast carcinomas therefore constitutively express the classical glandular keratins K7, K8,... 

T. Shibayama, H. Fukata, K. Sakurai, T. Adachi, M. Komiyama, T. Iguchi and C. Mori, Neonatal exposure to genistein reduces expression of estrogen receptor alpha and androgen receptor in testes of adult mice. Endocr. J. 48 (2001) 655-663. 

Kim MY, Woo EM, Chong YT, Homenko DR, Kraus WL (2006) Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the DNA binding and transactivation activities of the receptor. Mol Endocrinol... 

Morito, K., Hirose, T., Kinjo, J., et al. (2001). Interaction of phytoestrogens with estrogen receptors alpha and beta, Biol. Pharm. Bull., 4, 351-356. 

R. Metivier, G. Penot, M. R. Hubner, G. Reid, H. Brand, M. Kos, and F. Gannon, Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115, 751-763 (2003). 

Long, L. M. Olson, S. C. Bobzin, H. Irth High resolution screening of plant natural product extracts for estrogen receptor alpha and beta binding activity using an online HPLC-MS biochemical detection system, f Biomol Screen 2001, 6, 291-303. 

OECD. 2006e. Stably transfected transcriptional activation TA) assay for detecting estrogenic activity of chemicals - The human estrogen receptor alpha mediated reporter gene assay using HeLa-hER-9903 cell line. Version October 2006. Paris OECD, http //www.oecd.org/dataoecd/49/55/37531918.pdf... 

The data for this example was derived from the supplementary material of the estrogen receptor (ER) ChIP-on-chip publication of Carroll et al. [20]. The dataset consists of three replicates of specific enrichments for the estrogen receptor alpha and RNA Polymerase II versus input controls. All three replicates were performed on the Affymetrix human tiling 1.0 microarrays (14-chip set). 

Mueller SO, Simon S, Chae K, Metzler M, Korach KS. Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor (alpha) and ER(beta) in human cells. Toxicol ScL 81, 530-531, 2004. 

Dataset 2 is an ER-inhibitor dataset obtained from Pub-Chem (26). The dataset consists of 86,098 compounds tested on both ER-a (Bioassay 629 HTS of Estrogen Receptor-alpha Coactivator Binding inhibitors, Primary Screening) and ER-f) (Bioassay 633 HTS for Estrogen Receptor-beta Coactivator Binding inhibitors, Primary Screening). 

Virgili F, Acconcia F, Ambra R, Rinna A, Totta P, Marino M. 2004. Nutritional flavonoids modulate estrogen receptor alpha signaling. IUBMB Life 56 145-151. 

Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138 863-870. 

Anter E, Chen K, Shapira OM, Karas RH, Keaney JF Jr. 2005. p38 mitogen activated protein kinase activates eNOS in endothelial cells by an estrogen receptor alpha-dependent pathway in response to black tea polyphenols. Circ Res 96 1072-1078. 

Figtree GA, McDonald D, Watkins H, Channon KM. 2003. Truncated estrogen receptor alpha 46-kDa isoform in human endothelial cells Relationship to acute activation of nitric oxide synthase. Circulation 107 120-126. 

Estrogen receptor alpha and ERp consist of a hypervariable N-terminal domain that contributes to the transactivation function (A/B), a highly conserved central domain responsible for specific DNA binding, dimerization, and nuclear localization (C), an estrogenbinding domain (E), a hinge region domain (D), and a domain (F) whose function is not known (Tonetti and Jordan, 1997). 

Poola, I., Koduri, S., Chatra, S., and Clarke, R. 2000. Identification of twenty alternatively spliced estrogen receptor alpha mRNAs in breast cancer cell lines and tumors using splice targeted primer approach. J. Steroid Biochem. Mol. Biol. 72 249-258. 

Brouchet L, Krust A, Dupont S, Chambon R Bayard E Arnal JR Stradiolaccelerates reendothelialization in mouse carotid artery through estrogen receptor-alpha but not estrogen receptor-beta. Circulation 2001 103 423-428. 

Fuqua SA, Wiltschke C, Zhang QX, Borg A, Castles CG, Friedrichs WE, Hopp T, Hilsenbeck S, Mohsin S, O Connell P, Allred DC. A hypersensitive estrogen receptor-alpha mutation in premalignant breast lesions. Cancer Res 2000 60(15) 4026-4029. 

Herrington DM. Role of estrogen receptor-alpha in pharmacogenetics of estrogen action. Curr Opin Lipidol 2003 14(2) 145-150. 

Shearman AM, Cupples LA, Demissie S, Peter I, Schmid CH, Karas RH, Mendelsohn ME, Housman DE, Levy D. Association between estrogen receptor alpha gene variation and cardiovascular disease. J Am Med Assoc 2003 290(17) 2263-2270. 

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