Ligand binding specificity

IA (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors a and (3. Endocrinol. 138, 863-70. 

ErbB (or HER in the human). There are four ErbB receptors that form homo- or heterodimers in various combinations upon ligand binding. Specific NRG isoforms preferentially interact with different ErbB dimers. The ErbB receptors are ligand-activated tyrosine kinases structurally similar to the EGF receptor. 

M. Kiriyama, F. Ushikubi, T. Kobayashi, M. Hirata, Y. Sugimoto, S. Nammiya, Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells, Br. J. Pharmacol. 122 (1997) 217. 

Kobilka, B. K., Kobilka, T. S., Daniel, K., Regan, J. W., Caron, M. G., and Lefkowitz, R. J. (1988). Chimeric alpha 2-,beta 2-adrenergic receptors Delineation of domains involved in effector coupling and ligand binding specificity. Science 240, 1310-1316. 

Du G. and Prestwich G. D. (1995) Protein structure encodes the ligand binding specificity in pheromone binding proteins. Biochemistry 34, 8726-8732. 

Venhorst J, ter Laak AM, Commandeur JN, et al. Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities. J Med Chem 2003 46 74—86. 

Kuiper, G.G.J.M., Carlsson, B., Grandien, K., Enmark, E., Haggblad, J., Nilsson, S. and Gustafsson, J.A., Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta, Endocrinology, 138, 863-870, 1997. 

Elleman, T. C., Domagala, T., McKern, N. M., Nerrie, M., Lonnqvist, B., Adams, T. E., Lewis, J., Lovrecz, G. O., Hoyne, P. A., and Richards, K. M. et al. (2001). Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain. Biochemistry 40, 8930-8939. 

Paas, Y, Eisenstein, M., Medevielle, F., Teichberg, V. I., and Devillers-Thiery, A. (1996). Identification of the amino acid subsets accounting for the ligand binding specificity of a glutamate receptor. Neuron 17, 979-990. 

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