Human breast tumor

Soto AM, Soimenschein C. 1985. The role of estrogens on the prohferation of human breast tumor cells (MCE-7). J Steroid Biochem 23 87-94. 

Embrechts, J. Lemiere, F. Dongen, W. V. Esmans, E. L. Buytaert, P. van Marck, E. Kockx, M. Makar, A. Detection of estrogen DNA-adducts in human breast tumor tissue and healthy tissue by combined nano LC-nano ES tandem mass spectrometry. J. Am. Soc. Mass Spec from. 2003, 14, 482M-91. 

Johnston SR, Lu B, Dowsett M, Liang X, Kaufmann M, Scott GK, Osborne CK, Benz CC (1997) Comparison of estrogen receptor DNA binding in untreated and acquired antiestrogen-resistant human breast tumors. Cancer Res 57 3723-3727... 

This section summarizes the current information about different human keratins, their functional significance, cell-type-specific distribution as well as their coexpression with myoepithelial markers and estrogen receptor alpha (ER), because these markers exhibit characteristic expression patterns in some human breast tumors. In many of these cases, a definite diagnosis can be achieved only when additional information is provided by immunohistochemistry. 

Raziuddin A, Court D, Sarkar FH, Liu YL, Kung H, Raziuddin R (1997) A c-erbB-2 promoter-specific nuclear matrix protein from human breast tumor tissues mediates NF-kappaB DNA binding activity. / Biol Chem 272(25) 15715-15720... 

Noseda A, Berens ME, White JG, Modest EJ (1988) In vitro antiproliferative activity of combinations of ether lipid analogues and DNA interactive agents against human tumor cells. Cancer Res 48 1788-1791 Obeid LM, Linardic CM, Karolak LA, Hannun YA (1993) Programmed cell death induced by ceramide. Science 259 1769-1771 O Brian CA, Vogel, VG, Singletary SE, Ward NE (1989a) Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue. Cancer Res 49 3215-3217... 

O Brian C, Vogel VG, Singletary SE, et al. Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue. Cancer Res 1989 49(12) 3215-3217. 

Perou CM, Sorlie T, Eisen MB et al. Molecular portraits of human breast tumors. Nature... 

The system includes various software packages for different applications (De Cresce, 1986). It allows immunostained histological sections to be represented as digitized images from which the optical densities of the DAB reaction product over a specific cell part or component (e.g., nucleus) can be quantitated. Bacus et al. (1988) have successfully quantified the estrogen receptor content in human breast tumors. The data showed excellent sensitivity and specificity. 

Hudziak, R. M., Lewis, G. D., Winger, M., Fendly, B. M., Shepard, H. M., and Ullrich, A., 1989. pl85 HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor. Mol. Cell Biol. 9 1165-1172. 

Fig. 7.3. A dot plot (on the left) showing the staining of cells from a human breast tumor for two intracellular proteins. Cytokeratin-positivity marks tumor cells in the suspension, and estrogen receptor positivity on these cells indicates superior prognosis. The plot on the right shows a correlation (in 27 breast tumors) between the intensity of estrogen receptor staining by flow cytometry and the level of estrogen receptor binding (by radioligand binding assay). Modified from Ian Brotherick et al. (1995).

Sinha, B.K. et al. (1989) Adriamycin activation and oxygen free radical formation in human breast tumor cells protective role of glutathione peroxidase in adriamycin resistance, Cancer Res. 49, 3844-3848. 

HER-1 and HER-2 inhibitors consisting of 4-methyl-lH-benzimidazole derivatives, (V), prepared by Wittman (5) were effective against the MCF-7 human breast tumor cell line. 

Nagami, H., Matsumoto, Y., and Ueoka, R. (2006), Induction of apoptosis by hybrid liposomes for human breast tumor calls along with activation caspases, Biol. Pharm. RwZZ., 29, 380-381. 

Mehta, K., Pantazis, P., McQueen, T., and Aggarwal, B.B., Antiprohferation effect of curcumin (diferuloyhnethane) against human breast tumor cell lines. Anticancer Drugs, 8, 470, 1997. 

Hohnes FA, Fritsche HA, Loewy JW, Geitner AM, Sutton RC, et al. Measurement of estrogen and progesterone receptors in human breast tumors Enzyme immunoassay versus binding assay. J Clin Oncol 1990 8 1025-35. 

Herrnring, C., Reimer, T., Jeschke, U., Makovitzky, J., Kruger, K., et al. (2000) Expression of the apoptosis-inducing ligands FasL and TRAIL in malignant and benign human breast tumors. Histochem. Cell Biol. 113, 189-194. 

In human breast tumor cell lines, endothelins have been reported to induce CCR7 expression at both mRNA level and protein level through activation of endothelin receptor A (ET-RA) in a hypoxia-inducible factor-la (HIF-la)-dependent manner [40]. The endothelin system includes three small 21-amino acid peptides ligands (ET-1, ET-2, and ET-3), two G-protein-coupled receptors (ET-RA and ET-RB), and two activating peptidases [41]. Increased expression of endothelins and their receptors was found in invasive breast cancer compared to normal breast tissues or benign fibroadenomas [42, 43]. In human primary breast cancer, endothelin expression was correlated with CCR7 expression, both of which were associated with LN metastasis [40]. 

Hynes NE, Gerber HA, Saurer S, et al. Overexpression of the c-erbB-2 protein in human breast tumor cell lines. J Cell Biochem 1989,... 

---