17 Beta -estradiol

Chen ZS, Lee K, Kruh GD. Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4 Resistance to 6-mercap-topurine and 6-thioguanine. J Biol Chem 2001 276(36) 33747—33754. 

Loe, D.W., Almquist, K.C., Cole, S.P. and Deeley, R.G. (1996) ATP-dependent 17 beta-estradiol 17 - (beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. Journal of Biological Chemistry, 271, 9683-9689. 

Kaliwal, B. B., and M. A. Rao. Effect of carrot seed (Daucus carota) extract on estrous cycle as compared with that of estradiol-17-beta in albino rats. Comp Physiol Ecol 1983 8(2) 101-104. Kaliwal, B. B., and M. A. Rao. Inhibition of ovarian compensatory hypertrophy by carrot seed (Daucus carota) extract of estradiol-17beta in hemi-castrated albino rats. Indian J Exp Biol 1981 19 1058-1060. 

Kaliwal, B. B. Efficacy of carrot seed Daucus carota) extract in inhibiting implantation and its reversal as compared with estradiol-17-beta in albino rats. J Curr Biosci 1989 6(3) 77—82. Lokar, L. C., and L. Poldini. Herbal remedies in the traditional medicine of the Venezia Giulia region (north east Italy). J Ethnopharmacol 1988 22(3) 231-239. 

Lee YJ, Kusuhara H, Sugiyama Y. Do multidrug resistance-associated protein-1 and -2 play any role in the elimination of estradiol-17 beta-glucuronide and 2,4-dinitrophenyl-S-glutathione across the blood-cerebrospinal fluid barrier J Pharm Sci 2004 93 99-107. 

Wiese, T.E., Polin, L.A., Palomino, E., and Brooks, S.C., Induction of the estrogen specific mitogenic response of MCF-7 cells by selected analogues of estradiol-17 beta A 3D QSAR study, J. Med Chem., 40, 3659-3669, 1997. 

C2. Carson, R. S., Trounson, A. O., and Findlay, J. K., Successful fertilisation of human oocytes in vitro Concentration of estradiol-17 beta, progesterone and androstenedione in the antral fluid of donor follicles. J. Clin. Endocrinol. Metab 55, 798-800 (1982). 

Dehennin L. Estradiol-17 beta determined in plasma by gas chromatography-mass spectrometry with selected ion monitoring of mixed silyl ether-perfluoroacyl ester derivatives and use of various stable-isotope-iabeled internal standards. Clin Chem 1989 35 532-6. 

Sodergard R, Backstrom T, Shanbhag V, Carstensen H. Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. J Steroid Biochem 1982 16 801-10. 

Tamate K, Charletoii M, Gosling JP, Egan D, Ishikawa M, FottreU PF, et al. Direct colorimetric monoclonal antibody enzyme immunoassay for estradiol-17 beta m saliva. Glin Chem 1997 43 1159-64. 

Thienpont LM, Verhaeghe PG, Van Brussel KA, De Leenheer AP. Estradiol-17 beta quantified in serum by isotope dilution-gas chromatography-mass spectrometry reversed-phase C18 high-performance liquid chromatography compared with immuno-affinity chromatography for sample pretreatment. Clin Chem 1988 34 2066-9. 

Chen, Z.S., Robey, R.W., Belinsky, M.G., Shchaveleva, 1., Ren, X.Q., Sugimoto, Y. et al. (2003) Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2 effects of acquired mutations at R482 on methotrexate transport. Cancer Research, 63 (14), 4048-4054. 

J Grenier. Plasma estradiol-17-beta assay, using an enzyme immunoassay kit— Comparison with a specific radioimmunoassay. J Steroid Biochem 33 833, 1989. 

Cholesterol — pregnenolone — progesterone —> androstenedione — estradiol 17 beta — estrone —> estriol... 

Tamaya T, Motoyama T et al (1979) Estradiol-17 beta-, progesterone and 5 alpha-dihydrotestosterone receptors of uterine myometrium and myoma in the human subject. J Steroid Biochem 10 615-622... 

Di Cosmo A, Di Cristo C, Paolucci M (2002) A estradiol-17 beta receptor in the reproductive system of the female of Octopus vulgaris characterization and immunolocalization. Mol Reprod Dev 61 367-375... 

On the other hand, it is possible to underline an estrogenie aetivity of PAHs and their metabolites. One of the best described modes of action is the erosstalk between aetivated AhR and ER (Safe and Wormke, 2003). PAHs have been shown to be aetive in various ER-mediated systems that measure either the displacement of 3H-Estradiol-17 beta from the ER in a whole-cell binding assay (Arcaro et al., 1999) or the induetion of ER-mediated reporter activity (Charles et al., 2000 Fertuek et al., 2001a, 2001b Tran et al., 1996 Vondracek, 2002), thus indicating the potential role for estrogenieity. 

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