Estrogen actions

Targeting Estrogen Action in a Tissne-Specific Manner The SERM Concept... 

BELCHER s M and ZSARNOVSZKY A (2001) Estrogenic actions in the brain estrogen, phytoestrogens and rapid intracellular signalling mechanisms. J Pharmacol Exp Then 299 (2) 408-14. 

As an example of suspected endocrine disruptors (EDs), studies of the estrogenic action of bisphenol A (BPA) have been in progress in medical, physiological, and biological fields. In this situation, physicochemical approaches are required to get the structural information of BPA trapped in biomembranes. Most recently, we have determined the site and the orientation of BPA trapped in phospholipid vesicles by NMR, using the HCS rule [47]. In particular, we have succeeded in monitoring the NMR spectral changes of phospholipid vesicles, which are induced by the BPA delivery. 

Kuiper, G. G. J. M., Shughrue, P. J., Merchenthaler, I. and Gustafsson, J.-A. The estrogen receptor (3 subtype a novel mediator of estrogen action in neuroendocrine systems. Frontiers Neuroendocrinol. 19 253-286,1998. 

Molecular Mechanisms of Estrogen Action in Target Tissues... 

McEwen BS, Alves SE (1999) Estrogen actions in the central nervous system. Endocr Rev 20 279... 

Nilsson S, Makela S, Treuter E, Tujangue M, Thomsen J, Anderson G, Enmark E, Pettersson K, Warner M, Gustafsson JA (2001) Mechanisms of estrogen action. Physiol Rev 81 1535... 

Segars JH, Driggers PH (2002) Estrogen action and cytoplasmic signaling cascades. Part I Membrane-associated signaling complexes. Trends Endocrinol Metab 13 349... 

Action of Selective Estrogen Receptor Modulators (SERMs) Through the Classical Mechanism of Estrogen Action... 

To date, all the experiments done in animals with pure antiestrogens have disregarded any estrogenic actions of these compounds. Some of the described effects are presented here, arranged by the tissue or organ where they have been described (Table 6.2). 

In conclusion, we are at a very preliminary step on what is probably a long but promising path. The modulation of estrogen action seems a powerful mechanism in the control of CVD risk. Additional advances in the knowledge... 

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