Erythema intravenous

Hafnium salts are mild irritants of the eye and the skin and have produced liver damage in animals. In mice, the LDso of hafnyl chloride by intraperitoneal injection was 112 mg/kg. In cats, intravenous administration of hafnyl chloride at lOmg/kg was fatal. Rats fed a diet containing 1% for 12 weeks showed slight changes in the liver, consisting of perinuclear vacuolization of the parenchymal cells and coarse granularity of the cytoplasm. The application of 1 mg of hafnium chloride to the eyes of rabbits produced transient irritation. Topical application of hafiiium chloride crystals to unabraded rabbit skin produced transient edema and erythema application to abraded skin caused ulceration. ... 

Unithiol has been reported to have a low overall incidence of adverse effects (< 4%). Self-limited dermatologic reactions (drug exanthems or urticaria) are the most commonly reported adverse effects, although isolated cases of major allergic reactions, including erythema multiforme and Stevens-Johnson syndrome, have been reported. Because rapid intravenous infusion may cause vasodilation and hypotension, unithiol should be infused slowly over an interval of 15-20 minutes. 

Edell SL. Erythema multiforme secondary to intravenous glucagon. AJR Am J Roentgenol 1980 134(2) 385-6. 

Intravenous GHRH usually causes acute but transient adverse effects lasting several minutes. These effects include flushing, injection site pain and erythema, nausea, headache, metallic taste, pallor, and chest tightness. 

A 27-year-old woman developed peripheral target plaques, papules, blisters, and lip erosions, consistent with erythema multiforme, 9 days after using speed (dexamfetamine and ephedrine), and 3 days later developed widespread lesions with large areas of blistering affecting 40% of her body surface area. She was given intravenous ciclosporin and improved within 24 hours. 

Anthracyclines Dimethylsulfoxide Dexrazoxane Apply dimethylsulfoxide 99% topically Give intravenous dexrazoxane 1000 mg/m on days 1 and 2 and 500 mg/m on day 3 most effective if the first dose is given within 6 hours Apply a cold pack for 15 minutes, four times a day. Inspect after 24 hours and 7 days. If there are signs of erythema or ulceration after 7 days, discuss with a plastic surgeon... 

Rapid intravenous infusion of deferoxamine (more than 25 mg/kg over 30 minutes) can cause vertigo, hypotension, diffuse erythema, and generalized pruritus (11). Such reactions reverse on withdrawal of the infusion, although occasionally a fluid bolus and/or an antihistamine may be needed to reverse the symptoms more rapidly. This reaction is considered to be due to histamine release and not to be immunological in nature patients can be safely treated later at a lower rate of infusion. 

Skin reactions to intravenous immunoglobulin are rare (52,93-95). Other reported reactions include urticaria, maculopapular rashes, petechiae, eczema, and erythema multiforme (31,96). 

A 60-year-old man underwent coronary angiography with iopamidol 200 ml. One day later he developed infiltrated erythema of the face with a generalized maculopapular rash. The skin symptoms receded within 1 week after treatment with a corticosteroid ointment. Coronary angiography with iopamidol was repeated 3 years later and again within 1 day a maculopapular rash developed and regressed within a few days with intravenous dimethindene and prednisolone-21-hydrogen succinate. 

A 49-year-old man with acute myeloid leukemia underwent allogeneic bone marrow transplantation from his brother. Pre-existing pulmonary aspergillosis was treated with intravenous amphotericin. ACT scan of the chest and abdomen 120 ml of the non-ionic dimer iodix-anol was performed and 6 hours after the injection he developed generalized erythema with a pruritic painful skin rash. Skin biopsies showed changes typical of chronic graft-versus-host disease. He received prednisolone 50 mg orally and the rash resolved within a few weeks. 

Painful local subcutaneous reactions, erythema, urticaria, and pruritus have been observed after topical administration (1), as have fever and swelling, redness, heat, and pain at the injection site after intravenous administration (2). 

Cisplatin can cause anaphylactic shock, asthma, or urticaria (236). Hypersensitivity reactions, probably of type I, have also been reported after the administration of cisplatin, carboplatin, and oxaliplatin (237-243). Life-threatening allergy to cisplatin has also been reported after 16 doses of cisplatin 20 mg/m /week (244). These allergic reactions can include respiratory dysfunction (for example wheezing, dyspnea), gastrointestinal discomfort (for example abdominal cramps, diarrhea), and rashes (for example pruritus, urticaria, facial erythema, and swelling). The risk of exfoliative dermatitis is very low. In most patients, the first signs of hypersensitivity reactions usually occurred after the administration of multiple intravenous courses... 

Only three of 422 patients treated with a single dose of teicoplanin for antimicrobial prophylaxis during hip or knee arthroplasty (400 mg by intravenous bolus at the time of anesthesia) reported adverse events compared with nine of 424 patients treated with five doses of cefazo-line one had nausea and two had erythema (7). Six patients given teicoplanin had surgical wound infections, and 57 had proven or suspected infections involving other body systems. 

A 35-year-old woman with acute promyelocytic leukemia was given tretinoin 45 mg/m /day. On day 9 she became febrile (39.5°C) and had a sore throat with pharyngeal erythema and tender lymphadenopathy. The fever persisted despite cephalosporins, vancomycin, and antibiotics for anaerobic cover. On day 20 she developed severe bilateral anterior leg pain and both anterior tibial muscles were tender. Creatine kinase activity was 348 (reference range 38-176) U/1. Tretinoin was withdrawn and she was given intravenous dexamethasone 10 mg/day. Her fever resolved, her pain abated, and her leg muscles felt softer and less tender. Tretinoin was reintroduced and her symptoms returned. 

Erythema is inevitable after a phenol peel (Figure 37.18). ft can sometimes be less severe and of a shorter duration if a corticosteroid is injected intravenously at the beginning of the peel. Its intensity varies from patient to patient, from light and imperceptible to severe and deep. Resorcinol is a potentially allergenic phenol derivative persistent, pruritic erythema after a resorcinol peel might be a sign of contact dermatitis. 

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