Facial erythema

Clinically, rosacea presents with different degrees of severity, ranging from facial erythema to evident inflammatory lesions. Symptoms of rosacea include skin dryness and sensitivity, stinging and burning [1]. 

Erythemato-teleangectatic ush ng and persistent centro-facial erythema usually associated with teleangectasia (Figs. 17.2, 17.3)... 

Papulo-pustular persistent centro-facial erythema associated with inflammatory papules and pustules (Figs. 17.4,17.5 and 17.6)... 

Application to the face as lotion for acne treatment in two persons caused facial erythema and edema patch tests with benzoyl peroxide were positive. In contact with the eyes it may produce irritation, and if allowed to... 

Impaired wound healing, thin fragile skin, petechiae and ecchymoses, facial erythema, increased sweating, suppressed reaction to skin tests... 

A 46-year-old woman developed transient facial erythema with telangiectasia after each injection of interferon alfa, resolving within 1-2 days, and completely disappearing after definitive withdrawal of treatment 7 months later (301). 

Tursen U, Kay a TI, Ikizoglu G. Interferon-alpha 2b induced facial erythema in a woman with chronic hepatitis C infection. J Eur Acad Dermatol Venereol 2002 16(3) 285-6. 

In a 38-year-old non-atopic man, a generalized prurigi-nous maculopapular eruption with hp edema and facial erythema developed after 10 days of treatment with oral clindamycin phosphate (300 mg qds) and amoxicillin (500 mg qds) for bronchopneumonia (24). A patch test was positive 2 months later for clindamycin phosphate but negative for peniciUin, amoxiciUin, ampiciUin, and erythromycin. Prick tests and intradermal tests were all negative. Oral rechallenge with chndamycin phosphate 300 mg was positive. 

Cisplatin can cause anaphylactic shock, asthma, or urticaria (236). Hypersensitivity reactions, probably of type I, have also been reported after the administration of cisplatin, carboplatin, and oxaliplatin (237-243). Life-threatening allergy to cisplatin has also been reported after 16 doses of cisplatin 20 mg/m /week (244). These allergic reactions can include respiratory dysfunction (for example wheezing, dyspnea), gastrointestinal discomfort (for example abdominal cramps, diarrhea), and rashes (for example pruritus, urticaria, facial erythema, and swelling). The risk of exfoliative dermatitis is very low. In most patients, the first signs of hypersensitivity reactions usually occurred after the administration of multiple intravenous courses... 

Facial dermatitis Facial erythema Follicular eczema Generalized edema Gingivitis, bleeding gums Glossitis... 

Monkeys were exposed to varying concentrations and durations. At a Ct dosage of 2565 mg min m , only one animal responded, and that was with oral and nasal discharge, and diminished response to stimuli. A Ct of 8540mgminm resulted in ocular and nasal conjunctival congestion, facial erythema, and decreased responses, all of which were resolved... 

Edema Edema of lip Facial edema Facial erythema Hypersensitivity Lupus erythematosus (1986) Yasue T +, J Dermatol 13(4), 292 Pruritus Rash... 

Exfoliative erythroderma (1984) Stern RS+, JAMA 252, 1433 Facial erythema... 

Exfoliative erythroderma (2005) Moschella SL, Skinmed 4(1), 19 Facial erythema (1-5%)... 

The potency (effectiveness) of OC ( pepper ) sprays varies with the total concentration of extract used and the variability of the capsaicinoid composition of the extract used. Ten volunteer police officers were exposed to OC spray (5.5% OC) pointed at the face for 0.5-1.5 s they were examined before exposure and at 30 min, 1 day, 1 week and 1 month post-exposure (Vesaluoma et al., 2000). They reported mild to moderate facial and ocular stinging (mean duration 24 min range 4-50 min). They developed mild to moderate facial erythema and half had nasal congestion. At 1 min, there was a tachycardia (increased from basal 80 bpm to 116 bpm) and decreased to control values by 10 min. At 20 min, four volunteers had focal corneal epithelial cell... 

A recent multi-institution survey in Japan drew attention to an important effect of histamine H2 antagonists on docetaxel-induced skin toxicity. Analyses revealed that administration of H2 blockers was associated with a significantly higher incidence of acral erythema (hand-foot syndrome palmar-plantar erythrodysesthesia compare with hand-foot skin reaction. Sects. 13.3.2 and 13.3.3 and see Fig. 13.1) and facial erythema. Steroids and H2 blockers affect the metabolism of docetaxel by cytochrome P45o3A4 (CYP3A4), but dexamethasone dosage did not change the incidence of hand-foot syndrome or facial edema. 

Finally, 1ST is one of the therapeutic options for rosacea. However, the response of erythema to treatment with 1ST is usually slow and incomplete with common (0.5-1 mg/kg/day) or low (10 mg/day) doses. This study investigated the efficacy of, and relapse on, 20mg/day 1ST treatment in rosacea, with the aid of instrumental measurement of facial erythema and sebum levels [48 ]. 

A single case of DRESS S5mdrome was reported in a 63-year-old lady treated for an metiiidllin sensitive S. aureus infection with clindamycin for 4 days. This unfortunately progressed rapidly and led to death [88 ]. A 34-year-old female developed a hypersensitivity syndrome following 23 days of treatment with clindamycin (900 mg per day). The reaction consisted of a skin rash, fever, facial erythema and oedema [89 ]. 

Observational studies In a multicenter, observational retrospective review of 127 patients (80 male, mean age 51.7years) who had undergone at least ISmonths of treatment with alpha-l-antitrypsin therapy (Trypsone or Pro-lastin ), there were four serious adverse events that occurred during the treatment period one massive pulmonary thromboembolism, one myeloid leukaemia, one acute myocardial infarction and one haemorrhagic infarcHon but were judged not to be related to treatment. Seven of 11 nonserious adverse events were considered related to treatment including mild to moderate cutaneous symptoms (facial erythema, oedema/pruritus, rash), chills, fever and anxiety [31 ]. 

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