Embryos murine

Rat aortic smooth muscle Rat kidney PCT epithelial cells Rat primary hepatocyte culture Rat brain tumor cells Mouse embryo Murine lymphocytes Murine melanoma cells Murine 3T3 cells... 

Dunkel VC, Pienta RJ, Sivak A, et al. 1981. Comparative neoplastic transformation responses of Balb/3T-3 cells, Syrian hamster embryo cells, and Rauscher murine leukemia virus-infected Fischer 344 rat embryo cells to chemical carcinogens. J Nat Cancer Inst 67 1303-1315. 

In doses of 1.2 mg Ni/kg and up to 20 mg Ni/kg, nickel chloride caused increased resorption rates and a number of malformations in murine foetuses, specific to the foetal skeletal system, as shown by atomic absorption [425]. It was believed that nickel chloride might influence embryos during the passage through the oviduct, with subsequent effect on the development after implantation [426]. Preimplantation mouse embryos have also been used to investigate toxic effects of nickel chloride on early embryo development in vitro, and a dose-dependent effect has been found [427]. 

Barr, Dana B., et al. (2004). Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population. Environmental Health Perspectives 112(2) 186-200. Greenlee, A. R., T. M. Ellis, and R. L. Berg. (2004). Low-dose agrochemicals and lawn-care pesticides induce developmental toxicity in murine preimplantation embryos. Environmental Health Perspectives 112(6) 703-709. 

Nishikawa SI, Nishikawa S and Kawamoto H, et al (1998). In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos. Immunity 8 761-769. 

In the EST, two murine cell lines are used to assess teratogenic potential the embryonic D3 stem cell (ES) which represents the embryonic tissue and the 3T3 fibroblast cell which represents the adult tissue. The D3 cells are maintained in an undifferentiated stage in the presence of leukemia inhibiting factor (LIE), then released from LIE and allowed to form embryo bodies that differentiate into cardiomyocytes. The D3 and 3T3 cells are exposed to a range of concentrations of the test ingredient. After a 10-day... 

Blankenship AL, Suffia MC, Matsumura F, et al. 1993. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCCD) accelerated differentiation of murine preimplantation embryos in vitro. Reprod Toxicol 7(3) 255-261. 

Adams, R. H., Betz, H., and Piischel, A. W. (1996). A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryo-genesis. Mech. Dev. 57, 33-45. 

Winn LM, Wells PG. Phenytoin-initiated DNA oxidation in murine embryo culture, and embryo protection by the antioxidative enzymes superoxide dismutase and catalase Evidence for reactive oxygen species-mediated DNA oxidation in the molecular mechanism of phenytoin teratogenicity. Mol Pharmacol 1995 48 112-20. 

Chambers, A. F. and Wilson, S. (1988). Use of neor B16-F1 murine melanoma cells to assess clonality of experimental metastases in the immune-deficient chick embryo. Clin. Exptl. Metastasis 6, 171-182. 

Ozolins TR, Oglesby LA, Wiley MJ, et al. In vitro murine embryotoxicity of cyclophosphamide in embryos co-cultured with maternal hepatocytes development and application of a murine embryo-hepatocyte co-culture model. Toxicology. 1995 102(3) 259-274. 

The cytotoxicity of acetaminophen has been demonstrated in cultures of HeLa cells, L929 and 3T3 murine fibroblasts, chick embryo neurons, rat embryonic and skeletal muscle, peripheral blood lymphocytes, and lung and dermal cells. In addition cytotoxicity of acetaminophen has been evaluated in BF-2 fish cell line (see section on Ecotoxicology ). 

Peters JM, Wiley LM. 1995. Evidence that murine preimplantation embryos express aryl hydrocarbon receptor. Toxicol. Appl. Pharmacol. 134 214-21... 

Greenlee AR, Ellis TM, Berg RL. Low-dose agrochemicals and lawn-care pesticides induce developmental toxicity in murine preimplantation embryos. Environ Health Perspect 2004 112 (6) 703 9. 

Murine embryonic stem (mES) cells are pluripotent cell lines established directly from the early embryo [31, 32]. Since the early 1980s, numerous mES cell lines from several strains have been isolated and maintained in vitro according to... 

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