Electron-capture atmospheric mass spectrometry

Lee SH, Blair lA. Targeted chiral lipidomics analysis by liquid chromatography electron capture atmospheric pressure chemical ionization mass spectrometry (LC-ECAPCI/ MS). Methods Enzymol 2007 433 159-174. 

Higashi, T. Yamauchi, A. Shimada, K. Application of 4-(4-nitrophenyl)-l,2,4-triazoline-3,5-dione to analysis of 25-hydroxyvitamin D3 in human plasma by hquid chroma-tography/electron capture atmospheric pressure chemical ionization-mass spectrometry. Anal. Sci. 2003, 19 (6), 941-943. 

Today, electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) are considered the standard ionization techniques for LC-MS/MS due to their predominant advantages in quantitative analysis of drug molecules in various sample matrices with high sensitivity, selectivity, reliability, robustness, and ease of operation. Other techniques, for example, atmospheric pressure photoionization (APPI), electron capture atmospheric pressure chemical ionization (EC-APCI), and high-field asymmetric waveform ion mobility mass spectrometry (FAIMS) serve as complements to the established ESI and/or APCI technical platforms whenever necessary for an enhanced sensitivity and/or selectivity of a bioanalytical assay [4,5]. 

Lee, S.H., Williams, M.V., DuBois, R.N. and Blair, LA. (2003) Targeted lipidomics using electron capture atmospheric pressure chemical ionization mass spectrometry. Rapid Com-mun. Mass Spectrom. 17, 2168-2176. 

Song LG, Wellman AD, Yao HF, Adcock J. Electron capture atmospheric pressure photoionization mass spectrometry analysis of fullerenes, perfluorinated compounds, and pentafluorobenzyl derivatives. Rapid Comm Mass Spec 2007 21(8) 1343—51. 

DGE a AC AMS APCI API AP-MALDI APPI ASAP BIRD c CAD CE CF CF-FAB Cl CID cw CZE Da DAPCI DART DC DE DESI DIOS DTIMS EC ECD El ELDI EM ESI ETD eV f FAB FAIMS FD FI FT FTICR two-dimensional gel electrophoresis atto, 10 18 alternating current accelerator mass spectrometry atmospheric pressure chemical ionization atmospheric pressure ionization atmospheric pressure matrix-assisted laser desorption/ionization atmospheric pressure photoionization atmospheric-pressure solids analysis probe blackbody infrared radiative dissociation centi, 10-2 collision-activated dissociation capillary electrophoresis continuous flow continuous flow fast atom bombardment chemical ionization collision-induced dissociation continuous wave capillary zone electrophoresis dalton desorption atmospheric pressure chemical ionization direct analysis in real time direct current delayed extraction desorption electrospray ionization desorption/ionization on silicon drift tube ion mobility spectrometry electrochromatography electron capture dissociation electron ionization electrospray-assisted laser desorption/ionization electron multiplier electrospray ionization electron transfer dissociation electron volt femto, 1CT15 fast atom bombardment field asymmetric waveform ion mobility spectrometry field desorption field ionization Fourier transform Fourier transform ion cyclotron resonance... 

ECD = electron capture detector FID = flame ionization detector GC = gas chromatography HRGC = high resolution gas chromatography LC-APCI-MS = liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry LSE = liquid-solid extraction MS = mass spectrometry PVC = polyvinyl chloride SFE = supercritical fluid extraction... 

In addition, new tandem mass spectrometry technologies were also among the important innovations. Apart from traditional collision-induced dissociation (CID) [89-91], a variety of activation methods (used to add energy to mass-selected ions) based on inelastic collisions and photon absorption have been widely utilized. They include IR multiphoton excitation [92,93], UV laser excitation [94—97], surface-induced dissociation (SID) [98-100], black body radiation (101, 102], thermal dissociation [103], and others. As the fragmentation of peptide/protein ions is a central topic in proteomics, there is strong interest in such novel ion dissociation methods as electron capture dissociation (ECD) [104, 105] and electron transfer dissociation [22]. These new methods can provide structural information that complements that obtained by traditional collisional activation. Also, very recently, ambient ion dissociation methods such as atmospheric pressure thermal dissociation [106] and low temperature plasma assisted ion dissociation [107] have been reported. 

G Tang, BA Andrien, GG Dolnikowski, RM RusseU. Atmospheric pressure chemical ionization and electron capture negative chemical ionization mass spectrometry... 

Horning, E.C., Caroll, D.I., Dzidic, I., and Stillwell, R.N. (1981) Negative ion atmospheric pressure ionization mass spectrometry and the electron capture detector, in Electron Capture, Journal of Chromatography Library, Vol. 20 (eds A. Zlatkis and C.F. Poole), Elsevier, Amsterdam. 

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