Ebola

Many enveloped viruses share a common mechanism of fusion, mediated by a virus-encoded glycoprotein that contains heptad repeats in its extraceUnlar domain. Dnring the fnsion process, these domains rearrange to form highly structured and thermodynamically stable coiled-coils. Viruses encoding fusion proteins that have these domains inclnde members of the paramyxovirus family (e.g., respiratory syncytial virus, metapneumovirus, and measles virus), ebola virus, influenza, and members of the retroviridae (e.g., human T cell lenkemia virus type-1 and human immunodeficiency virus type-1, HlV-1). Peptide inhibitors of fusion that disrupt the... 

Filoviruses Ebola virus Long filamentous rods composed of a lipid envelope surrounding a helical nucleocapsid lOOOnm long, 80nm in diameter The virus is widespread amongst populations of monkeys. It can be spread to humans by contact with body fluids from the primates. The resulting haemorragic fever has a 90% case fatality rate... 

Susceptibility of viruses to antimicrobial agents can depend on whether the viruses possess a lipid envelope. Non-lipid viruses are frequently more resistant to disinfectants and it is also likely that such viruses cannot be readily categorized with respect to their sensitivities to antimicrobial agents. These viruses are responsible for many nosocomial infections, e.g. rotaviruses, picornaviruses and adenoviruses (see Chapter 3), and it may be necessary to select an antiseptic or disinfectant to suit specific circumstances. Certain viruses, such as Ebola and Marburg which cause haemorrhagic fevers, are highly infectious and their safe destruction by disinfectants is of paramount importance. 

Acute myocardial infarction Angiopathy Aortic aneurysm Aortic balloon assist devices Giant hemangiomas Peripheral vascular disease Postcardiac arrest Prosthetic devices Raynaud s syndrome Infectious Arbovirus Aspergillus Candida albicans Cytomegalovirus Ebola virus... 

Viral hemorrhagic fever (e.g., Ebola) Flu-like symptoms, internal bleeding 2 to 21 days... 

Ebola-gp 1, or Dengue-gp E. DC-SIGN is also known to oligomerize, and it is therefore particularly important to understand the intrinsic binding and multivalent binding requirements of this lectin. 

F. Lasala, E. Arce, J. R. Otero, J. Rojo, and R. Delgado, Mannosyl glycodendritic structure inhibits DC-SIGN-mediated Ebola vims infection in cis and in trans, Antimicrob. Agents Chemother., 47 (2003) 3970-3972. 

Material Safety Data Sheet-Infectious Substances Ebola Virus. November 6, 2002. 

Fact Sheet 103 Ebola Hemorrhagic Fever. Geneva Health Communications and Public... 

If you are a first responder, HMRT member, firefighter, police officer, or emergency medical service person called to an incident, any incident, remember the following information about biological incidents. Except in unusual circumstances, you can t see a biological agent they are odorless, colorless, and tasteless. There is a delay in incubation even the much feared ebola fever which has a moderate transmissibility from person to person... 

Also in 2002, government scientists revealed that over two dozen dangerous biological agents including anthrax, and Ebola went unaccounted for in the early 1990s at the US Army Medical Research Unit (USAMRIID) in Fort Detrick, Maryland. The location of these agents, which were subject to removal without authorization, remains a mystery. 

In another case in February of 2004, a researcher was exposed to Ebola virus at the United States Army laboratory at Fort Detrick, MD. 

Annex 12 Skin biopsy on fatal cases for diagnosis of Ebola... 

In 1995, an outbreak of Ebola VHF affected more than three hundred people in and around the city of Kikwit in the Democratic Republic of the Congo (the former Zaire) and approximately 80 percent of the victims died. An international investigation team worked with local authorities to introduce VHF isolation precautions as well as standard precautions. When the types of precaution featured in the manual mentioned above were installed in Kikwit, no further nosocomial (hospital) transmission of the Ebola virus was documented. 

Biological Agents BACTERIA (Anthrax, Brucellosis, Cholera, Plague, Tularemia). VIRUSES (Crimean-Congo Hemorrhagic Fever, Rift Valley Fever, Smallpox, Venezuelan Equine Encephalitis (VEE), Viral Hemorrhagic Fever (Ebola)). TOXINS (Botulinum, Ricin, Staphylococcal Enterotoxin B (SEB), Trichothecene Mycotoxins/T-2). 

Peters, C.J. Marburg and Ebola virus hemorrhagic fevers. In Mandell, G.L., Bennett, J.E., Dolin, R., eds. Principles and practice of infectious diseases. 5th ed. New York, New York Churchill Livingstone 2000, 2, 1821-3. 

Ebola Fever Aerosol Moderate High 7-9 days 5-15 days High Relatively unstable No Not effective No... 

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