Ebola viruses

Many enveloped viruses share a common mechanism of fusion, mediated by a virus-encoded glycoprotein that contains heptad repeats in its extraceUnlar domain. Dnring the fnsion process, these domains rearrange to form highly structured and thermodynamically stable coiled-coils. Viruses encoding fusion proteins that have these domains inclnde members of the paramyxovirus family (e.g., respiratory syncytial virus, metapneumovirus, and measles virus), ebola virus, influenza, and members of the retroviridae (e.g., human T cell lenkemia virus type-1 and human immunodeficiency virus type-1, HlV-1). Peptide inhibitors of fusion that disrupt the... 

Filoviruses Ebola virus Long filamentous rods composed of a lipid envelope surrounding a helical nucleocapsid lOOOnm long, 80nm in diameter The virus is widespread amongst populations of monkeys. It can be spread to humans by contact with body fluids from the primates. The resulting haemorragic fever has a 90% case fatality rate... 

Acute myocardial infarction Angiopathy Aortic aneurysm Aortic balloon assist devices Giant hemangiomas Peripheral vascular disease Postcardiac arrest Prosthetic devices Raynaud s syndrome Infectious Arbovirus Aspergillus Candida albicans Cytomegalovirus Ebola virus... 

Material Safety Data Sheet-Infectious Substances Ebola Virus. November 6, 2002. 

In another case in February of 2004, a researcher was exposed to Ebola virus at the United States Army laboratory at Fort Detrick, MD. 

In 1995, an outbreak of Ebola VHF affected more than three hundred people in and around the city of Kikwit in the Democratic Republic of the Congo (the former Zaire) and approximately 80 percent of the victims died. An international investigation team worked with local authorities to introduce VHF isolation precautions as well as standard precautions. When the types of precaution featured in the manual mentioned above were installed in Kikwit, no further nosocomial (hospital) transmission of the Ebola virus was documented. 

Peters, C.J. Marburg and Ebola virus hemorrhagic fevers. In Mandell, G.L., Bennett, J.E., Dolin, R., eds. Principles and practice of infectious diseases. 5th ed. New York, New York Churchill Livingstone 2000, 2, 1821-3. 

Ebola virus, Marburg virus, Lassa fever, Argentine and Bolivian hemorrhagic fevers, Crimean Congo hemorrhagic fever, Rift Valley fever, dengue hemorrhagic fever,... 

Martin-Serrano, j., Zang, T., and Bieniasz, P. D. HlV-1 and Ebola virus encode small peptide motifs that recruit TsglOl to sites of particle assembly to facilitate egress. Nature Med. 2001, 7, 1313-19. 

Sullivan, N.J., A. Sanchez, RE. Rollin, Z.Y. Yang, and GJ. Nabel, Development of a preventive vaccine for Ebola virus infection in primates. Nature, 2000.408(6812) 605-9. 

Geisbert, T.W., P. Pushko, K. Anderson, J. Smith, K.J. Davis, and PB. Jahriing, Evaluation in nonhuman primates of vaccines against Ebola virus. Emerg Infect Dis, 2002. 8(5) 503-7. 

Investigators at the Centers for Disease Control and Prevention confirmed that the Ebola virus is behind outbreak of hemorrhagic fever in Zaire. 

FIGURE 19.4 Inhibition strategy in which the synthetic glycodendrinanoparticle competes with Ebola virus for binding to DC-SIGN-displaying cells. 

Figure 21.8 Transmission electron micrograph of Ebola virus. CDC/C. Goldsmith...

Which of the following is the natural reservoir for Ebola virus ... 

Feldmann, H., Jones, S. M., Schnittler, H. J., Geisbert, T. (2005). Therapy and prophylaxis of Ebola virus infections. Current Opinion in Investigational Drugs, 6(8), 823-830. 

Ebola-like viruses Ebola virus Vertebrates... 

The structure of the Ebola virus matrix protein (VP40) has been determined (Dessen et al, 2000). It has two domains of the same, unique topology (Fig. 10) consisting of sandwiches made from two three-stranded antiparallel / sheets. The topology bears no resemblance to other viral matrix proteins of known structure. Indeed, differences in the sequence suggest that it might be different from the closest related of other families, including Paramyxoviridae and Rhabdoviridae (Dessen et al, 2000). 

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