Dimethylhydrazine, colon tumor

Nelson R.L. Chlorophyllin, an antimutagen, acts as a tumor promoter in the rat dimethylhydrazine colon carcinogenesis model. Anticancer Res., 12, 737, 1992. 

With XA1PcS3, selective photonecrosis of colonic tumors induced with dimethylhydrazine was observed with low drug doses (0.5 mg kg-1), but selectivity over normal tissue disappeared at 5 mg kg-1.329 The use of this material (in the form of PHOTOSENS as a mixture of di- and tri-sulfonic acids (7)) in extensive clinical treatments in Moscow has been referred to in Section 9.22.4. 

Deschner, E.E., Long, EC. Hakissian, M. (1988) Susceptibility to 1,2-dimethylhydrazine-induced colonic tumors and epithelial cell proliferation characteristics of FI, F2, and reciprocal backcrosses derived from SWR/J and AKR/J parental mouse strains. Cancer, 61, 478-482... 

Nauss, K.M., Locniskar. M., Pavlina, T. Newbeme, PM. (1984) Morphology and distribution of 1,2-dimethylhydrazine dihydrochloride-induced colon tumors and their relationship to gut-associated lymphoid tissue in the rat. J. natl Cancer Inst., 73, 915-924... 

Newaz, S.N., Fang, W.-F. Strobel, H.W. (1983) Metabolism of the carcinogen 1,2-dimethylhydrazine by isolated human colon microsomes and human colon tumor cells in culture. Cancer, 52, 794-798... 

Pollard, M. Zedeck, M.S. (1978) Induction of colon tumors in 1,2-dimethylhydrazine-resistant Lobund Wistar rats by methylazoxymethanol acetate. J. natl Cancer Inst., 61. 493-494 Pozharisski, K.M., Kapustin, Y.M., Likhachev, A.J. Shaposhnikov, J.D. (1975) The mechanism... 

Schiller, C.M., Curley, W.H. McConnell, E.E. (1980) Induction of colon tumors by a single oral dose of 1,2-dimethylhydrazine. Cancer Lett., 11, 75-79... 

The Bowman-Birk inhibitor also blocks the transformation of C H/10T1/2 cells (18). This raises the speculation that BB may represent a direct acting nutritionally relevant anticarcinogen particularly in the case of colon cancer. In this regard it was recently reported that e-aminocaproic acid (a trypsin inhibitor) inhibits dimethylhydrazine-induced colon tumors in mice (22). 

A series of studies show that sphingolipids derived from milk protect against development of colon tumors in mice. In the initial study (Dillehay et al., 1994), mice fed diets supplemented with 0.025, 0.050 or 0.1% sphingomyelin had less than half the incidence of 1,2-dimethylhydrazine (DMH)-induced colon tumors than mice fed non-supplemented diets. In addition, a diet supplemented with 0.025% of the ganglioside GMj produced significantly fewer DMH-induced aberrant crypt foci (ACF) than control animals. ACF are microscopically determined pre-neoplastic lesions that can develop into colon tumors. 

Cook MG, McNamara P. 1980. Effect of dietary vitamin E on dimethylhydrazine-induced colonic tumors in mice. Cancer Res 40 1329-1331. 

Llor X, Jacoby RF, Teng BB, et al. 1991. K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors Effects of supplemental dietary calcium and vitamin D deficiency. Cancer Res 51 4305-4309. 

Shirai T, Nakanowatari J, Kurata Y, et al. 1983. Different dose-response relationships in the induction of different types of colonic tumors in wistar rats by 1,2-dimethylhydrazine. Gann 74 21-27. 

Jacobs MM, Jansson B, Griffin AC. 1977a. Inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazooxymethanol acetate induction of colon tumors. Cancer Lett 2 133-138. 

Gali-Muhtasib, H.U., Younes, I.H., Karchesy, J.J., and El-Sabban, M.E., Plant tannins inhibit the induction of aberrant crypt foci and colonic tumors by 1,2-dimethylhydrazine in mice, Nutr. Cancer, 39, 108-116,2001. 

It has been shown that CLA was able to protect against 2-amino-3-methylimida-zo[4,5-/]quinoline-induced colon carcinogenesis in F344 rats (25). A recent study (26) demonstrated that 1% dietary CLA significantly decreased colon tumor incidence in the colon of 1,2-dimethylhydrazine (DMH)-treated rats, and the apoptotic index estimated by the terminal deoxynucleotidyl transferase-mediated dUTP nick... 

Deschner, E. E., Florence, C. L., Hakissian, M., and Hermann, S. L., 1983, Differential susceptibility of AKR, C57BL/6J and CFl mice to 1,2-dimethylhydrazine induced tumor formation predicted by proliferative characteristics of colonic epithelial cells, J. Natl. Cancer Inst. 70 279. 

Wilson, R. B., Hutcheson, D. P., and Wideman, L., 1977, Dimethylhydrazine induced colon tumors in rats fed diets containing beef fat or corn oil with and without wheat bran. Am. J. Clin. Nutr. 30 176. 

Barbolt and Abraham[37] fed rats a diet containing 20% bran and administered 1,2-dimethylhydrazine (DMH) orally as well. There was 100% incidence of colon tumors in the control rats and 67% incidence in the bran-fed rats. The number of tumors per rat was 6.4 0.9 in the controls and 1.2 0.6 in the bran-fed group (p<0.001). There were no differences between the two groups in incidence of duodenal or cecal tumors. Thus, the effect of dietary bran was localized to the colon. Freeman et al.[38] obtained similar when they fed cellulose as the dietary fiber. Neither substance binds bile acids to any appreciable extent[10]. 

Toth, B. Effect of Metamucil on tumor formation by 1,2-dimethylhydrazine dihydrochloride in mice. Food Chem Toxicol 1984 22(7) 573-578. Dooley, D. P., M. Rhodes, and D. Drehner. Psyllium worm. Amer J Gastroenterol 1993 88(1) 153-154. Alabaster, O., Z. C. Tang, A. Frost, and N. Shivapurkar. Potential synergism between wheat bran and psyllium enhanced inhibition of colon cancer. Cancer Lett 1993 75(1) 53-58. 

Dimethylhydrazine (DMFI)-induced rat colon carcinogenesis model was used for evaluation of the synergistic inhibitory effect between curcumin and catechin in light of ACF formation and tumor incidence. The results of this... 

If you are exposed to hydrazines, you may have an increased cancer risk. The cancer-causing effects of hydrazines have not been well studied in people. However, many studies show that hydrazines can cause cancer in some animals after exposure to doses of 0.06-19 mg/kg/day through the mouth or exposure to concentrations of 0.05-5 ppm in the air. Tumors have been seen in many organs of animals exposed in this way but were found most often in the lungs, blood vessels, or colon. Some of the cancers caused by 1,1-dimethylhydrazine may have been due to the presence of dimethylnitrosamine (a powerful carcinogen) as an impurity of this chemical. It is of particular concern that 1,2-dimethylhydrazine has caused colon cancer in lab animals following a single exposure. 

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