Colon tumor incidence

TABLE II. AOM-INDUCED COLON TUMOR INCIDENCES IN FEMALE F344 RATS FED THE DIETS CONTAINING CORN OIL, SAFFLOWER OIL, OLIVE OIL, AND... 

Thus, the excretory pattern of fecal secondary bile acids observed in these studies correlated with colon tumor incidences in animal models. These studies also suggest that high dietary intake of certain types of fat may be necessary for the full expression of risk for colon cancer. 

Table XI. Colon Tumor Incidence With Two Levels and Types of...

Epidemiological studies show that dietary fat and protein are most frequently correlated with colon cancer incidence in man (10-14). A number of studies in laboratory animals suggest that dietary fat enhances colon tumor incidence (15) although others have failed to show such enhancement (16). Summarized in this communication are animal experiments conducted by our laboratory to examine the effects of dietary protein on DMH induced carcinogenesis, mutagenesis, and toxicity. 

Kim, K.H. and Park, H.S., Dietary supplementation of conjugated linoleic acid reduces colon tumor incidence in DMH-treated rats by increasing apoptosis with modulation of biomarkers, Nutrition, 19, 772, 2003. 

Colon Tumor Incidence in Female F344 Rats Fed Diets Containing Pectin, Alfalfa, or Wheat Bran and Treated with... 

The effect of dietary wheat bran and dehydrated citrus fiber at 15% level and 5% dietary fat on intestinal carcinogenesis induced by AOM and DMAS was studied in male F344 rats (44,45). Composition of diets was adjusted so that all animals in different experimental groups consumed approximately the same amount of protein, fat, minerals and vitamins. The animals fed the wheat bran or citrus fiber and treated with AOM had a lower Incidence (number of animals with tumors) and multiplicity (number of tumors/tumor bearing rat) of colon tumors and tumors of the small Intestine than did those fed the control diet and treated with AOM (Table II 15). Although 15% purified pectin in the diet (41) inhibited the colon tumor incidence better than did 15% dehydrated citrus fiber, in this study the Inhibition of colon tumor multiplicity was more pronounced with the dehydrated citrus fiber compared with purified pectin. Because dehydrated citrus fiber contains about 20% pectin, the pectin content of this diet was considerably lower than that of the diet used in... 

Colon Tumor Incidence in F344 Male Rats fed Diets Containing Wheat Bran or Citrus Fiber... 

It has been shown that CLA was able to protect against 2-amino-3-methylimida-zo[4,5-/]quinoline-induced colon carcinogenesis in F344 rats (25). A recent study (26) demonstrated that 1% dietary CLA significantly decreased colon tumor incidence in the colon of 1,2-dimethylhydrazine (DMH)-treated rats, and the apoptotic index estimated by the terminal deoxynucleotidyl transferase-mediated dUTP nick... 

Female CF-1 mice were s.c. injected with AOM (5, 10, 10, and 10 mg/Kg body wei t) starting at 6 weeks of age once every 4 days resulted in formation of an average of 0.52 colon tumors per mouse and 44% of mice had colon tumor at 37 weeks after the first dose of AOM injection. Feeding 0.2% orange peel extract or 0.2% nordihydroxyguaiaretic acid in the diet to mice inhibited the number of AOM-induced colon tumor per mouse by 44% or 48%, respectively. Colon tumor incidence was reduced by 34% or 39%, respectively (Table II). 

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