Diluents mannitol

Hydrochloithiazide 0.5-5 mg Acetone 2 x 3-5 mL for 15-150 mg hydrochlorthiazide 3 g diluent Mannitol with 0.5 % mA Colloidal anhydrous silica, compressed [33]... 

Sorbitol is a hexahydric alcohol that is isomeric with mannitol, and which has been described as a humectant, plasticizer, sweetening agent, and tablet and capsule diluent. It is used extensively in the pharmaceutical, cosmetics, and food industries, since it has a sweet taste and approximately 50-60% the sweetness of sucrose. 

Powder for Injection 15-mg vial with diluent (diluent includes 0.6 ml mannitol (3%) in water for injection). 

MCC, lactose, calcium phosphate dibasic, and mannitol were selected as common tableting diluents and were evaluated as received from their vendors. These materials are summarized in Table 2. Each material is available from several vendors with multiple grades. Three grades within each excipient were selected for their diverse range of physical and mechanical properties (3). These materials typically comprise 5% to 70% of a formulation. The samples were stored at environmentally controlled laboratory conditions of 20 2°C and 40% 10% relative humidity. 

The comparison of heroin exhibits has also been used successfully in court in helping to establish a conspiracy. Comparative analyses were conducted on five exhibits from two different cases. The preliminary examination revealed that the excipients and diluents in each case were sucrose, quinine hydrochloride, mannitol, com starch, and lactose monohydrate. 

Diluents. In general, diluents make up most of the dosage form. The selection of diluents is very important, especially for low-dose formulations, since they may make up 85-95% of the granulation. These diluents may be soluble or insoluble. The most commonly used soluble fillers include lactose, mannitol and sucrose. Commonly used insoluble fillers include microcrystalline cellulose, starch, calcium sulfate, and dibasic calcium phosphate. 

Tablet diluent Inert substance used as filler to create desired bulk, flow properties, and compression characteristics in preparation of tablets Dibasic calcium phosphate, kaolin, lactose, mannitol, microcrystalline cellulose, powdered cellulose, precipitated calcim carbonate, sorbitol, starch...

Diluents calcium phosphate, calcium hydrogen phosphate, calcium sulphate, glucose, kaolin, lactose, mannitol, colloidal silica, sodium chloride sodium sulphate, sorbitol. 

IFN (3-Ib (Betaseron) is a purified protein produced by recombinant DNA technology with 165 amino acids and approximate molecular weight of 18,500 daltons. Lyphylized vials contain 0.3 mg IFN(3-lb with mannitol (15 mg) and albumin (15 mg) as stabilizers. Reconstitution with the diluent supplied produces a 0.54% sodium chloride solution. IFN (3-lb or Betaseron is also dispensed in a pre-filled syringe at a dose of 22 ig (6MIU) per dose for 66j.tg/week. A higher dose of 44 j.Lg (12 MIU) per dose for 132 j.tg per week is also available. The recommended dosing schedule is three times a week as a subcutaneous injection. 

Chewable tablets. These tablets are preferred for pediatric and geriatric patients who have difficulty swallowing whole tablets. Another advantage is that they do not need water for administration. Mannitol is normally used as the base diluent because of its pleasant taste and texture, and because it can effectively mask the taste of objectionable actives. They are usually prepared by wet granulation and are not compressed very hard. High amounts of flavor are added to increase palatability. Antacids are typically formulated as chewable tablets. 

Diluent To act as a bulking agent or filling material Sugars, lactose, mannitol, sorbitol, sucrose Inorganic salts, primarily calcium salts Polysaccharides, primarily microcrystalline celluloses... 

Mannitol is an osmotic diuretic that has been used in acute oliguric renal insufficiency, acute cerebral edema, and the short-term management of glaucoma, especially to reduce intraocular pressure before ophthalmic surgery. Other indications include promotion of the excretion of toxic substances by forced diuresis, bladder irrigation during transurethral resection of the prostate, and oral administration as an osmotic laxative for bowel preparation. Mannitol is used as a diluent and excipient in pharmaceutical formulations and as a bulk sweetener. 

Mannitol is widely used in pharmaceutical formulations and food products. In pharmaceutical preparations it is primarily used as a diluent (10-90% w/w) in tablet formulations, where it is of particular value since it is not hygroscopic and may thus be used with moisture-sensitive active ingredients. 

Mannitol has also been used to prevent thickening in aqueous antacid suspensions of aluminum hydroxide (<7% w/v). It has been suggested as a plasticizer in soft-gelatin capsules, as a component of sustained-release tablet formula-tions, and as a carrier in dry powder inhalers. It is also used as a diluent in rapidly dispersing oral dosage forms. 

USE Used with boric acid in the manuf of dry electrolytic condensers for radio applications in making artificial resins and plasticizers in pharmacy as excipient and diluent for solids and liqs in analytical chemistry for boron determinations in the manuf of mannitol hexanitrate. Used in the food industry as anticaking and free f]ow agent flavoring agent, Lubricant and release agent, stabilizer and thickener and nutritive sweetener,... 

Therefore, if when carrying out a preformulation study we wished to compare the effects of 4 diluents (e.g. lactose, calcium phosphate, microcrystalline cellulose, and mannitol), 3 disintegrants, 2 binders, 2 lubricants, and a glidant (e.g. presence or absence of colloidal silica), it is easy to verify that the model contains 14 coefficients (including the constant term), but only 9 of these are independent. 

Diluent lactose microcrystalline cellulose (M.C.C.) corn starch calcium phosphate dihydrate mannitol (see experimental design, table 9.10) 91%... 

F. Vecuronium bromide (Norcuron, others), 10-mg vials of lyophilized powder for reconstitution (Norcuron contains mannitol and diluent may contain benzyl alcohol). The suggested minimum stocking level to treat a 70-kg adult for the first 24 hours is three vials. 

Bryostatin I 2 Tumor necrosis factor-a (TNF-a) Bryostatin lyophilized from butanolic solution with povidone to be dissolved in PEG 400, ethanol, and Tween 80 mixture (PET diluent) followed by dilution in normal saline immediately before administration Lyophilized solution with mannitol and the sugar based amorphous protectant dextran, sucrose, or cyclodextrin in citrate buffer Improved drug solubility with reduced requirement of cosolvents for administration and improved shelf-life of the lyophilized formulation StabiUzation of solution from tendency for dimeric and polymeric self-aggregation, leading to the formation of particulates in solution... 

Mannitol Diluent, sweetner, bulking agent for lyophilized products... 

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