Damaged systems

Cyclodextrinyl ditelluride has been recognized as an excellent glutathione peroxidase mimic, revealed in die mitochondrial damage system induced by ferrous sulphate/ascor-bate. ... 

Storage/Stability- Do not store outside the pouch provided. Damaged systems should not be used. The drug reservoir may be burst by excessive pressure or heat. Discard systems in household trash in a manner that prevents accidental application or ingestion by children, pets, or others. 

Stewart and McVey (1994) describe the design of a deinventory system for a hydrofluoric acid (HF) alkylation unit. The purpose of this deinventory system is to mitigate an accidental release by removing the hazardous materials rapidly from the leaking or damaged system to a safe location. 

Fig. 9 Diagrams presenting the critical longitudinal strains (bold numbers) corresponding to the successive stages of damage. System A = Si N /Al, System B = Si N /Al O /Al,...

B. Skin and mucous membranes. Strong iodine tincture (7% iodine and 5% potassium iodide in 83% ethanol) may cause bums, but USP iodine tincture (2% iodine and 2% sodium iodide in 50% ethanol) is not likely to produce corrosive damage. Systemic absorption of iodine may occur after an acute application of strong iodine tincture or after chronic applications of less concentrated products. 

In the normal business transaction of any commodity, the case which meets the requirement of customer less than 20% or less may be considered undesirable if not fraudulent [13], It is thus necessary to develop anticancer drugs with more universal, more tumor selective, or pinpoint targeting potential, which may not be as specific as antibody, but cover universal characteristics of solid tumor, and are thus capable of eradicating total cancer cells without damaging systemic immune and other vital functions. We believe a clue for this tumor-selective delivery is seen in the EPR effect-based drug development, and its further augmentation is technically possible. 

Severity The measure of seriousness of the effect of failure mode (consequence of a failure classified by the degree of injury, property damage, system damage, and mission loss that could occur) it is described in FMEA/ FMECA in the scale of 1—10. 

Multiorgan damage Systemic fibrosis due to gadolinium-based contrast agents was reviewed in SEDA-31 (p. 735) and many other reviews have appeared [SEDA-32, 852], The EIDOS and DoTS descriptions of this reaction are shown in Figure 3 the susceptibility factors include drugs (epoetin therapy, sevelamer) and diseases (renal insufficiency, acidosis, inflammatory events, hyperphosphatemia). The risks from different contrast agents are shown in Table 3. 

GI Tract May cause irritation of the digestive tract. May cause kidney damage. Systemic Effects May cause kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. 

In the last decades, deterioration of existing structures has been a growing concern. Deterioration due to corrosion of reinforcement steel has been of particular interest since the associated reduction of the steel section results in a decrease of the structural safety. An other topic which has been the subject of many publications is the assessment of the structural robustness. Different approaches have been proposed in order to quantify this structural robustness through robustness indicators (Sorensen et al. 2012). The robustness indicator based on the reliability index of the undamaged and the damaged system, is the reliability-based robustness index. 

A probabilistic approach based on the probability of failure of the undamaged and the damaged system ... 

Since the rehabihty index of the undamaged and the damaged system are not precisely known, also the redundancy index, as defined by (16), is not precisely known. Hence, the random variable Br = Pr(Pj(0), Pg(0)) is introduced. As a random variable, Br has a PDF fgRlBg) and characteristics such as a mean pgR and a standard deviation OgR. 

The system safety process should particularly be invoked when a system can kiU, injure, or maim humans. It should always be applied as good business practice, because the cost of safety can easily be cheaper than the costs of not doing safety (i.e., mishap costs). en system safety is not performed, system mishaps often result, and these mishaps generate associated costs in terms of deaths, injuries, system damage, system loss, lawsuits, and loss of reputation. 

Attard XL, Dansby RE (2008) Evolutionary control of damaged systems using a rehabilitative algorithm. In Proceedings of tenth pan American congress of applied mechanics PACAM X. Grand Oasis Resort Cancun, Mexico, pp 166-169... 

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