Nervous system damage

Freed, W.J., de Medinaceli, L., Wyatt, R.J. (1985). Promoting functional plasticity in the damaged nervous system. Science 227 1544-52. 

Ingestion of moldy foods may also cause health effects such as liver damage, nervous system damage, and immunological effects. 

Absorbed by dermal inhalation and oral routes, results in garlic breath . Damages nervous system like lead. Mild effects reported in workers. Peripheral neuropathy and paralysis in rats. 

Neurological effects Damaged nervous system (The nervous system is the most sensitive)... 

Polymeric materials can lead to great development in tissue engineering of damaged nervous system, but there are still many questions to be answered before their application, such as type and characteristic of polymer and the complementary methods which are appropriate for specific neurological dysfunctions and further investigation is needed to promote them as ideal scaffolds for nervous tissue engineering. 

Full eye protection should be worn whenever handling acryhc monomers contact lenses must never be worn. Prolonged exposure to Hquid or vapor can result in permanent eye damage or blindness. Excessive exposure to vapors causes nose and throat irritation, headaches, nausea, vomiting, and dizziness or drowsiness (solvent narcosis). Overexposure may cause central nervous system depression. Both proper respiratory protection and good ventilation are necessary wherever the possibiHty of high vapor concentration arises. 

Effects of repeated ethylene glycol peroral overexposure in treated rats and mice can result in kidney, Hver, and nervous system damage. The most sensitive indicators of ethylene glycol toxicity are disturbances in acid—base balance and nephrotoxic (kidney) effects. Effects of repeated chronic peroral overexposure of diethylene glycol in treated rats result in kidney and Hver damage (48). 

Exposure to excessive amounts of lead over a long period of time (chronic exposure) increases the risk of developing certain diseases. The parts of the body which may be affected include the blood, nervous system, digestive system, reproductive system, and kidneys. These effects include anemia, muscular weakness, kidney damage, and reproductive effects, such as reduced fertiHty in both men and women, and damage to the fetus of exposed pregnant women. 

Phenol. Phenol monomer is highly toxic and absorption by the skin can cause severe blistering. Large quantities can cause paralysis of the central nervous system and death. Ingestion of minor amounts may damage kidneys, Hver, and pancreas. Inhalation can cause headaches, dizziness, vomiting, and heart failure. The threshold limit value (TLV) for phenol is 5 ppm. The health and environmental risks of phenol and alkylated phenols, such as cresols and butylphenols, have been reviewed (66). 

Bromothiophenes are toxic materials by aU routes. Inhalation toxicity of 2-bromothiophene is significant. Ecotoxicity is also noted for these materials, particularly for 2-bromo-3-methylthiophene. 2-Thiophenecarboxaldehyde and the 3-methyl derivative can cause minor irritation to the skin and eyes of rabbits. The former is a sensitizer to guinea pig skin, the latter is not. 2-Acetylthiophene is toxic in aU modes of contact. Severe exposure causes serious inflammation of the lung, damage to many organs, and depression of the central nervous system. 

Toxicity of 2-Ghloroethanol. Ethylene chlorohydrin is an irritant and is toxic to the Hver, kidneys, and central nervous system. In addition, it is rapidly absorbed through the skin (73). The vapor is not sufficiently irritating to the eyes and respiratory mucous membranes to prevent serious systemic poisoning. Contact of the Hquid in the eyes of rabbits causes moderately severe injury, but in humans corneal bums have been known to heal within 48 hours. Several human fataUties have resulted from inhalation, dermal contact, or ingestion. One fatahty was caused by exposure to an estimated 300 ppm in air for 2.25 hours. In another fatal case, autopsy revealed pulmonary edema and damage to the Hver, kidneys, and brain (73). 

In nonindustrial settings, MCS substances are the cause of indoor air pollution and are the contaminants in air and water. Many of the chemicals which trigger MCS symptoms are known to be irritants or toxic to the nervous system. As an example, volatile organic compounds readily evaporate into the air at room temperature. Permitted airborne levels of such contaminants can still make ordinary people sick. When the human body is assaulted with levels of toxic chemicals that it cannot safely process, it is likely that at some point an individual will become ill. For some, the outcome could be cancer or reproductive damage. Others may become hypersensitive to these chemicals or develop other chronic disorders, while some people may not experience any noticeable health effects. Even where high levels of exposure occur, generally only a small percentage of people become chemically sensitive. 

Toxicity. Breathing moderate amounts of methyl ethyl ketone (MEK) for short periods of time can cause adverse effects on the nervous system ranging from headaches, dizziness, nausea, and numbness in the fingers and toes to unconsciousness. Its vapors are irritating to the skin, eyes, nose, and throat and can damage the eyes. Repeated exposure to moderate to high amounts may cause liver and kidney effects. 

Xylenes (total) 10 10 Nervous system damage Discharges from petroleum and chemical plants... 

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