Damaged systems repairability

Chopp, M., Chan, P. H., Hsu, C. Y., Cheung, M. E. and Jacobs, T. P. DNA damage and repair in central nervous system injury National Institute of Neurological Disorders and Stroke Workshop Summary. Stroke 27 363-369,1996. 

Positive results from the bacterial DNA damage or repair tests indicate that the test substance causes DNA damage, which is expressed as differential cell killing or growth inhibition of repair deficient bacteria. The DNA damage tests do not measure DNA repair per se nor do they measure mutations. A positive result in a DNA damage test in the absence of a positive result in another system is difficult to evaluate in the absence of a better database. 

Barea, F. and Bonatto, D. (2008). Relationships among carbohydrate intermediate metabolites and DNA damage and repair in yeast from a systems biology perspective. Mutat. Res. 642,... 

Davies KJA. Oxidative stress, antioxidant defenses, and damage removal, repair and replacement systems. IUBMB Life 2000 50 279-289. 

Mammalian cells in culture permit several end points to be measured simultaneously in the same cell system. These include malignant transformations, chromosomal changes, and DNA damage and repair, as well as specific-locus mutation.26... 

Williams, G.M. Review of in vitro test systems using DNA damage and repair for screening of chemical carcinogens. J. Assoc. Official Anal. Chem. 62 857-863, 1979. 

Uberti D, Ferrari Toninelli G, and Memo M (2003) Involvement of DNA damage and repair systems in neu-rodegenerative process. Toxicology Letters 139 99-105. 

Spectroscopic investigations in the UV concern areas of photobiology with an impact on photomedicine, e.g. light activation of enzymes, UV-radiation effects on the immune system and on cellular membranes, the interaction of drugs with DNA (Chapter 4.2.2 and 4.2.3) and the role of DNA damage and repair in mutagenesis and carcinogenesis. 

Mismatched bases (bases that do not form normal Watson-Crick base pairs) are recognized by enzymes of the mismatch repair system. Because neither of the bases in a mismatch is damaged, these repair enzymes must be able to determine which base of the mispair to correct. 

Chopp M, Chan PH, Hsu CY, Cheung ME, Jacobs TP. DNA damage and repair in central nervous system injury National institute of neurological disorders and stroke workshop summary. Stroke. 1996 27 363-369... 

---