Chemotactic Protein

Berger EA, Murphy PM, Farber JM (1999) Chemokine receptors as HIV-1 coreceptors roles in viral entry, tropism, and disease. Annu Rev Immunol 17 657-700 Bernasconi S, Cinque P, Peii G, Sozzani S, Crociati A, Torri W, Vicenzi E, Vago L, Lazzarin A, Poli G, Mantovani A (1996) Selective elevation of monocyte chemotactic protein-1 in the cerebrospinal fluid of AIDS patients with cytomegalovirus encephalitis. J Infect Dis 174 1098-1101... 

Cinque P, Vago L, Mengozzi M, Torn V, Ceresa D, Vicenzi E, Transidico P, Vagani A, Sozzani S, Mantovani A, Lazzarin A, PoU G (1998) Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HlV-1 encephalitis and local viral rephcation. AIDS 12 1327-1332... 

IkB inhibitory protein kappa B lCAM-1 intercellular adhesion molecule 1 lL-1 interleukin-1 LDL low density lipoprotein MAPKs mitogen activated protein kinases MCP-1 macrophage chemotactic protein 1 M-CSF macrophage colony stimulating factor mmLDL minimally modified LDL NAC A-acetylcysteine NF-kB nuclear factor-kappa B oxLDL oxidised LDL PKC protein kinase C PMA phobol myristate acetate ROS reactive oxygen species TNF-a tumour necrosis factor alpha AM-1 vascular cell adhesion molecule 1... 

Kishimoto T, Oguri T, Ueda D, Tada M. 1996. Methylmercury modulation of monocyte chemotactic protein-1 mRNA expression in human peripheral blood mononuclear cells. Hum Cell 9 371-374. 

Navab, M., Imes, S.S., Hama, S.Y., Hough, G.P., Ross, L.A., Bork, R.W., Valente, A.J., Berliner, J.A., Drinkwater, D.C., Laks, H. and Fogelman, A.M. (1991). Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic endothelial cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein. J. Clin. Invest. 88, 2039-2046. 

M cell Microfold or membranous cell of Peyer s patch epithelium MCP Membrane co-factor protein MCP-1 Monocyte chemotactic protein-1... 

Preobrazhensky AA, Dragan S, Kawano T, et al. Monocyte chemotactic protein-1 receptor CCR2B is a glycoprotein that has tyrosine sulfation in a conserved extracellular N-terminal region. J Immunol 2000 165 5295-303. 

Li YS, Shyy YJ, Wright JG, Valente AJ, Comhill JF, Kolattukudy PE. The expression of monocyte chemotactic protein (MCP-1) in human vascular endothelium in vitro and in vivo. Mol Cell Biochem 1993 126(1) 61—68. 

Cushing SD, Berliner JA, Valente AJ, et al. Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. Proc Natl Acad Sci U S A 1990 87(13) 5134-5138. 

Wang JM, Sica A, Peri G, et al. Expression of monocyte chemotactic protein and interleukin-8 by cytokine-activated human vascular smooth muscle cells. Arterioscler Thromb 1991 11(5) 1166—1174. 

White JR, Lee JM, Dede K, et al. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J Biol Chem 2000 275(47) 36626-36631. 

Epithelial neutrophil activating protein-78 (ENA-78) Granulocyte chemotactic protein-2 (GCP-2) Neutrophil activating protein-2 (NAP-2) Interleukin-8 (IL-8)... 

Vande Broek I, Asosingh K, Vanderkerken K, et al. Chemokine receptor CCR2 is expressed by human multiple myeloma cells and mediates migration to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1, -2, and -3. Br J Cancer 2003 88 855-862. 

TNF (17.5) Monocyte/macrophage, lymphocyte, neutrophil, endothelium, fibroblast, keratinocyte Activation of T and B cells, natural killer cells, neutrophils, and osteoblasts. Stimulation of endothelial cells to release chemotactic proteins, NO and PGI2. Tumoricidal activity. Induces fever, sleep, hepatic acute phase protein synthesis, catabolism, ACTH release. Lead to myocardial depression, hypotension/shock, hypercoagulability, and death. Stimulates production of IL-1, IL-6, IL-8, IFN-y, and H202. Suppression of cytochrome P-450, thyroglobulin, and lipoprotein lipase. Induces complement activation, release of eicosanoids, including PAF. Procoagulant activity. 

Cui, HS, Hayasaka, S, Zhang, XY, Hayasaka, Y, Chi, ZL, and Zheng, LS, 2006. Effect of berberine on interleukin 8 and monocyte chemotactic protein 1 expression in a human retinal pigment epithelial cell line. Ophthalmic Res 38, 149-157. 

Finally, a new area of research has concentrated on monocyte chemotactic protein-1 (MCP-1), a 76-amino acid peptide that is one of the best-studied members of the C-C chemokine subfamily. Recent human and animal studies indicate that the recruitment of macrophages to the arterial lesion is predom-... 

Inhibition of leucocyte adhesion to endothelium. By acting on the gene transcription factor called nuclear factor kappa B (NFkB), NO limits the expression by endothelial cells of monocyte chemotactic protein-1 (MCP-1) and VCAM-1. As both MCP-1 and VCAM-1 are involved with pro-inflammatory responses, NO is in this manner an anti-inflammatory agent ... 

Younce, C. W., Azfer, A., and Kolattukudy, P. E. (2009). MCP-1 (monocyte chemotactic protein-l)-induced protein, a recently identified zinc finger protein, induces adipogen-esis in 3T3-L1 pre-adipocytes without peroxisome proliferator-activated receptor gamma.. Biol. Chem. 284, 27620-27628. 

Mediation of natural immunity type I interferons, IL-1, IL-6, and more than 40 chemokines (small highly basic chemotactic proteins). 

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