Cell differential effect

Veldscholte J, Berrevoets CA, Brinkmann AO, Grootegoed JA, Mulder E. Anti-androgens and the mutated androgen receptor of LNCaP cells differential effects on binding affinity, heat-shock protein interaction, and transcription activation. Biochemistry 1992 31 (8) 2393—2399. 

Roscetti G, Franzese O, Comandini A, Bonmassar E. Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells differential effects between methanolic extract and hypericin. Phytother Res 2004 18 66-72. 

Salh B, Wagey R, Marotta A, Tao JS, Pelech S. 1998. Activation of phosphati-dylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production. J. Immunol. 161 6947-54... 

Park SM, Jung HC, Koak IS et al. Oxidant-induced cell death in renal epithelial cells Differential effects of inot nic and organic hydroperoxides. Pharmacol Toxicol 2003 92 43-50. 

Tazarotene is a synthetic retinoid that mediates cell differentiation and proliferation [19]. Tazarotene, a pro-drug of tazarotenic acid,has recently been proven effective as a treatment for photodamaged skin [11]. 

Proudfoot AE, Buser R, Borlat F et al (1999) Amino-terminally modified RANTES analogues demonstrate differential effects on RANTES receptors. J Biol Chem 274 32478-32485 Qin AP, Zhang HE, Qin ZH (2008) Mechanisms of lysosomal proteases participating in cerebral ischemia-induced neuronal death. Neurosci Bull 24 117-123 Richter R, Bistrian R, Escher S et al (2005) Quantum proteolytic activation of chemokine CCL15 by neutrophil granulocytes modulates mononuclear cell adhesiveness. J Immunol 175 1599-1608... 

Dijkwel, P.A. and Wenink, P.W. (1986). Structural integrity of the nuclear matrix differential effects of thiol agents and metal chelators. J. Cell Sci. 84, 53-67. 

Azacitidine, a cytidine analog, causes hypomethylation of DNA, which normalizes the function of genes that control cell differentiation to promote normal cell maturation. The suspension is administered as a subcutaneous injection daily for 7 days for the treatment of myelodysplastic syndrome, a preleukemia disease. The pharmacokinetics of azacitidine are best described by a two-compartment model, with a terminal half life of 3.4 to 6.2 hours, whereas peak concentrations are achieved 30 minutes after a subcutaneous injection.7 Azacitidine has been shown to be clinically active in the treatment of myelodysplastic syndromes. The side effects include myelosuppression, renal tubular acidosis, renal dysfunction, and injection-site reactions. 

Edgar Some of the Minutes have been reported to give small cell phenotypes in adults. We have looked at a number in discs before the cells differentiate, and we have not seen any effects here. 

The differentiation effect of lycopene was associated with elevated expression of several differentiation-related proteins, such as cell surface antigen (CD14), oxygen burst oxidase and chemotactic peptide receptors (Amir et al., 1999). Recently, it has also been reported that lycopene was also able to stimulate the differentiation marker alkaline phosphatase activity in... 

SaOS-2 osteoblasts (Kim et al., 2003). Such an effect was shown to be dependent on the stage of cell differentiation. The mechanism of the differentiating activity of lycopene is still unclear. One of the most reliable hypothesis is that the carotenoid may activate the expression of nuclear hormone receptors, such as RAR and RXR (Sharoni et al., 2002). 

Asghari V, Reiach JS, Young LT. Differential effects of mood stabilizers on Fos/ Jun proteins and AP-1 DNA binding activity in human neuroblastoma SH-SY-5Y cells. Mol Brain Res 1998 58 95-102. 

Lu ZF et al (2007) Differentiation of adipose stem cells by nucleus pulposus cells configuration effect. Biochem Biophys Res Commun 359(4) 991-996... 

Neutropenia is a condition characterized by a decrease in blood neutrophil count below 1.5 X 109 cells per litre a normal blood count is (2.0-7.5) X 109 cells per litre. Its clinical symptoms include the occurrence of frequent and usually serious infections, often requiring hospitalization. Neutropenia may be caused by a number of factors (Table 10.6), at least some of which are responsive to CSF treatment. Particularly noteworthy is neutropenia triggered by administration of chemotherapeutic drugs to cancer patients. Chemotherapeutic agents (e.g. cyclophosphamide, doxorubicin and methotrexate), when administered at therapeutically effective doses, often induce the destruction of stem cells and/or compromise stem cell differentiation. 

Johnson, K.W., N.E. Kaminski, and A.E. Munson. 1987. Direct suppression of cultured spleen cell responses by chlordane and the basis for differential effects on in vivo and in vitro immunocompetence. Jour. Toxicol. Environ. Health 22 497-515. 

Lee, T.C., S. Wang-Wuu, R.Y. Huang, K.C.C. Lee, and K.Y. Jan. 1986b. Differential effects of pre-and posttreatment of sodium arsenite on the genotoxicity of methyl methanesulfonate in Chinese hamster ovary cells. Cancer Res. 46 1854-1857. 

Valverde MA, Mintenig GM, Sepulveda FV (1993) Differential effects of tamoxifen and I- on three distinguishable chloride currents activated in T84 intestinal cells. Pfliigers Arch 425(5-6) 552-554... 

KodaM,Jarzabek K, HaczynskiJ, Knapp P, SulkowskiS, Wolczynski S (2004) Differential effects of raloxifene and tamoxifen on the expression of estrogen receptors and antigen Ki-67 in human endometrial adenocarcinoma cell line. Oncol Rep 12(3) 517-521... 

Van den Beukel I, van Kleef RGDM, Oortgiesen M. Differential effects of physostigmine and organophosphates on nicotinic receptors in neuronal cells of different species. NeuroToxicol. 19(6) 777-788, 1998. 

While changes in cell phenotypes have proved useful in some settings to characterize the immunotoxicity of xenobiotics,1 phenotypic analysis alone is often not a sensitive indicator of low dose immunotoxicity for many agents that alter immune function. Xenobiotics that exert selective toxicity on lymphoid and myeloid cells may be discovered through immunophenotypic analysis. However, most agents produce immunotoxicity at doses much lower than those required to produce cytotoxicity or interfere with primary lymphoid organ differentiation. Some of the most potent immunosuppressive chemicals that have been tested, such as cyclosporine A, do not alter immunophenotype at doses that are immunosuppressive. On the other hand, when phenotyping is linked to assessment of functional parameters of the cells, immunotoxic effects are more likely to be identified. 

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