Ischemia, cerebral

Therapeutic opportunities for NO synthons include angina, for which nitroglycerin is effectively used, as well as penile erectile dysfunction. NOS inhibitors have demonstrated some protection in cerebral ischemia models and may be potentially beneficial in alleviating cell death associated with cerebral ischemia. l-NMA is under clinical study for treatment of sepsis. [Pg.565]

Kleinschnitz C, Stoll G, Bendszus M et al (2006) Targeting coagulation Factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. J Exp Med 203 513-518... [Pg.676]

Pignataro G, Gala R, Cuomo O et al (2004) Two sodium/ calcium exchanger gene products, NCX1 andNCX3, play a major role in the development of permanent focal cerebral ischemia. Stroke 35 2566-2570... [Pg.808]

Kornetsky C Hyporesponsivity of chronic schizophrenic patients to dextroamphetamine. Arch Gen Psychiatry 33 1425—1428, 1976 Kosten TR Pharmacotherapy of cerebral ischemia in cocaine dependence. Drug Alcohol Depend 49 133-144, 1998... [Pg.205]

Proudfoot AE, Buser R, Borlat F et al (1999) Amino-terminally modified RANTES analogues demonstrate differential effects on RANTES receptors. J Biol Chem 274 32478-32485 Qin AP, Zhang HE, Qin ZH (2008) Mechanisms of lysosomal proteases participating in cerebral ischemia-induced neuronal death. Neurosci Bull 24 117-123 Richter R, Bistrian R, Escher S et al (2005) Quantum proteolytic activation of chemokine CCL15 by neutrophil granulocytes modulates mononuclear cell adhesiveness. J Immunol 175 1599-1608... [Pg.170]

Yuh WT, Crain MR, Loes DJ, Greene GM, Ryals TJ, Sato Y. MR imaging of cerebral ischemia findings in the first 24 hours. Am J Neuroradiol. 1991 12 621-629. [Pg.29]

FurukawaM, Kashiwagi S, Matsunaga N, Suzuki M, Kishimoto K, Shirao S. Evaluation of cerebral perfusion parameters measured by perfusion CT in chronic cerebral ischemia comparison with xenon CT. J Comput Assist Tomogr 2002 26 272-278. [Pg.33]

Astmp J, Siesjo BK, Symon L. Thresholds in cerebral ischemia - the ischemic penumbra. [Pg.55]

The ongoing IMS III trial is a randomized, multicenter, phase III trial continuing the investigation into the efficacy of the combined IV and lA approach to treat acute stroke. Patients are being randomized to IV/IA therapy and IV rt-PA alone in a 2 1 ratio. In the group allocated to combination IV/IA therapy, the physician will select either the EKOS microcatheter or a standard microcatheter to infuse rt-PA, or select the Mechanical Embolus Removal in Cerebral Ischemia (MERCI) clot retrieval device. The primary outcome is the percentage of patients with an mRS score of 0-2 at 90 days. ... [Pg.70]

Smith WS. Safety of mechanical thrombectomy and intravenous tissue plasminogen activator in acute ischemic stroke. Results of the multi Mechanical Embolus Removal in Cerebral Ischemia (MERCI) trial, part I. Am J Neuroradiol 2006 27 1177-1182. [Pg.93]

Belayev L, Pinard E, Nallet H, Seylaz J, Liu Y, Riyamongkol P, Zhao W, Busto R, Ginsberg MD. Albumin therapy of transient focal cerebral ischemia in vivo analysis of dynamic microvascular responses. Stroke 2002 33 1077-1084. [Pg.117]

Marinov MB, Harbaugh KS, Hoopes PJ, Pikus HI, Harbaugh RE. Neuroprotective effects of preischemia intraarterial magnesium sulfate in reversible focal cerebral ischemia. J Neurosurg 1996 85 117-124. [Pg.117]

Du C, Hu R, Csemansky CA, Liu XZ, Hsu CY, Choi DW. Additive neuroprotective effects of dextrorphan and cycloheximide in rats subjected to transient focal cerebral ischemia. Brain Res 1996 718 233-236. [Pg.118]

Asahi M, Asahi K, Wang X, Lo EH. Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats. J Cereb Blood Flow Metab 2000 20 452 57. [Pg.118]

Yang Y, Li Q, Shuaib A. Enhanced neuroprotection and reduced hemorrhagic incidence in focal cerebral ischemia of rat by low dose combination therapy of urokinase and topiramate. Neuropharmacology 2000 39 881-888. [Pg.119]

Markarian GZ, Lee JH, Stein DJ, Hong SC. Mild hypothermia therapeutic window after experimental cerebral ischemia. Neurosurgery 1996 38 542-550 [discussion 551]. [Pg.119]

Ginsberg MD. H3fpothermic neuroprotection in cerebral ischemia. In Welch KMA, Caplan LR, Reis DJ, Siesjo BK, Weir B, editors Primer on cerebrovascular diseases. San Diego Academic Press 1997. p 272-275. [Pg.120]

Veltkamp R, Warner DS, Domoki F, Brinkhous AD, Toole JF, Busija DW. Hyperbaric oxygen decreases infarct size and behavioral deficit after transient focal cerebral ischemia in rats. Brain Res 2000 853 68-73. [Pg.120]

Schabitz WR, Schade H, Heiland S, Kollmar R, Bardutzky J, Henninger N, Muller H, Carl U, Toyokuni S, Sommer C, Schwab S. Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by mr-imaging. Stroke 2004 35 1175-1179. [Pg.120]

Roos JA, Jackson-Friedman C, Lyden P. Effects of hyperbaric oxygen on neurologic outcome for cerebral ischemia in rats. Acad Emerg Med 1998 5 18-24. [Pg.120]

Kawamura S, Yasui N, Shrrasawa M, Fukasawa H. Therapeutic effects of h3fperbaric oxygenation on acute focal cerebral ischemia in rats. Surg Neurol 1990 34 101-106. [Pg.121]

Singhal AB, Wang X, Sumii T, Mori T, Lo EH. Effects of normobaric h3fperoxia in a rat model of focal cerebral ischemia-reperfusion. J Cereb Blood Flow Metab 2002 22 861 868. [Pg.121]

Liu S, Shi H, Liu W, Eumichi T, Timmins GS, Liu KJ. Interstitial po2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 2004 24 343-349. [Pg.121]

Kim HY, Singhal AB, Lo EH. Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemia. Ann Neurol 2005 57 571-575. [Pg.121]

Cole DJ, Matsumura JS, Drummond JC, Schell RM. Focal cerebral ischemia in rats effects of induced hypertension, during reperfusion, on cbf. J Cereb Blood Flow Metab 1992 12 64-69. [Pg.121]

Morimoto T, Ginsberg MD, Deitrich WD, Zhao W. Hyperthermia enhances spectrin breakdown in transient focal cerebral ischemia. Brain Res 1997 746(l-2) 43-51. [Pg.190]

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