Risks phrases

Table 5. MSDS Environmental Hazard Risk Phrases ...

EXTREMELY ELAMMABLE (Where the substance or preparation falls within the definition given in Notes 3c) 9. DANGEROUS LOR THE ENVIRONMENT in combination with risk phrases 10 50... 

Substances or preparations requiring to be labelled with the risk phrase R45 (may cause cancer) or R49 (may cause cancer by inhalation) under CHIPS are listed in Table 5.16 after the 5th edition of the Approved Supply List (Information approved for the classification and labelling of substances and preparations dangerous for supply). This list excludes certain coal and oil-based substances which attract the phrase R45 only when they contain a certain percentage of a marker substance (e.g. benzene). 

Substances with the risk phrase R45 (may cause cancer)... 

Table 14.3 Risk phrases from the Approved List...

Any substance which under the Classification, Packaging and Labelling of Dangerous Substances Regulations 1984 (SI 1984/22, amended by SI 1986/1922 and SI 1988/766) has been assigned the risk phrase, R45 May Cause Cancer, and which is listed in Part (A) of the approved list. 

Requirements for labelling of containers for supply may differ from those for conveyance. Key features of a supply label are to identify the substance (the chemical name in most cases) and any hazards and safety precuations. In Europe the classification, packaging and labelling of dangerous substances is covered by Directive 67/548/EEC as amended. This requires labels to identify appropriate risk and safety phrases (Tables 12.2 and 12.3) depending upon product properties. A substance is considered dangerous if in Part lA of an approved list or if it exhibits hazardous properties as defined in Schedule 1 for supply, or Schedule 2 for conveyance as shown in Tables 12.4 and 12.5. Substances not tested should be labelled Caution — substance not yet fully tested . Criteria for risk phrases are provided, e.g. as in Table 12.6 for toxic compounds. 

Council Directive 67/548/EEC of 27 June 1967 on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances. Annex 1 of the directive assigns Risk Phrases to chemical substances. 

With the risk phrase R42 ("may cause sensitization by inhalation"),... 

Preparations containing >0,5% lead chromate are required to be labelled according to EU Guideline 67/548/EEC (Annex I) as toxic (Symbol skull and crossbones) and beside others with the Risk phrases R 40 (limited evidence of carcinogenic effect), R 61 (may cause harm to the unborn child) and R 62 (possible risk of impaired fertility). 

EC Risk phrases. The Physical and Theoretical Chemistry Laboratory, Oxford University, Oxford, UK (http //ptcl.chem.ox.ac.uk/MSDS/risk phrases.html). 

Risk labels, lATA/ICAO, 751-3 Risk phrases, 621, 748, 749 River water, peroxide determination, 642 RNA, ozone disinfection, 616 ROS see Reactive oxygen species Rose Bengal sensitized photooxidation, 890 Rotational barriers, regioselective allylic hydroperoxide formation, 836, 847-9 Rotational isomers, peroxynitrous add, 8-9 Rotational spectra, ozonides, 721, 722-3 RP-HPLC, hydrogen peroxide determination, 627... 

Key words REACH, Teratology, Labelling, Risk phrase... 

From the above it is clear that there will be many debates on whether Category 2 or 3 applies, and others where Category 3 applies or no risk phrase applies. Categories 2 or 3 would only be applied in exceptional cases if the information is not from in vivo data. 

The following risk phrases apply to the above categories ... 

Category 1 Symbol T and risk phrase R61 may cause harm to the unborn child. ... 

Assignment of Risk-Phrases/Hazard Statements to Teratogenic Chemicals... 

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