Cancer Protection

The polyphenol extract from the barley bran (BPE) induced the differentiation of human promyelocytic leukemia HL-60 cells, based on the expression of the differentiation markers such as nitro blue tetrazolium (NBT) reducing activity and a-naphthyl butyrate esterase activity. Prodelphini-din B-3, Tl, T2, and T3 induced 26-40% NBT-positive cells and 22-32% a-naphthyl butyrate esterase-positive cells. Proanthocyanidins might potentiate the retinoic acid (all-frarcs-retinoic acid)-induced granulocytic differentiation and sodium butyrate-induced monocytic differentiation in the HL-60 cells [101]. 

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Adlercreutz H. 1995. Phytoestrogens Epidemiology and a possible role in cancer protection. Environ Health Perspect 103(Supplement 7) 103-112. 

The present results also point to differences between the mammary tumor model and the ACT model for evaluating the potential cancer protective effects of Se in broccoli. A previous study (17) showed that high-Se broccoli florets decreased the number of DMH-induced ACT. Similarly, in the present study high-Se broccoli sprouts decreased DMH-induced ACT, but low-Se broccoli sprouts alone did not have any effect (Table 3). In the mammary tumor model, however, broccoli alone, similar to garlic alone (3), reduced the number of tumors (Table 1). This contrasting effect could be the result of a difference between tumor and preneoplastic lesion models, a difference between carcinogens, or a difference between mammary and colonic tissues. 

Recoupling Cancer-Protective Properties of Angle-Spinning NMR High-Selenium Broccoli A Class II Aldolase MimH ... 

The anticancer effect of soy, the only relevant dietary source of isoflavones and the main candidate foodstuff responsible for the cancer protection conferred by Asian diets, has been tested in a number of animal studies. Messina et al. [204] reviewed 26 such studies published up to 1994 (gastrointestinal and non gastrointestinal). Seventeen of them (65%) reported a protective effect and none found a potentiation of carcinogenesis. One study has examined the effect of feeding a soy protein diet in a genetic... 

Zoete Y, Rougee M, Dinkova-Kostova AT, Talalay P, Bensasson RY. 2004. Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital. Free Radic Biol Med 36 1418-1423. 

The basic idea that selenium is a cancer-protecting trace element began in the 1950s, when researchers tried to find substances that could prevent... 

Prochaska HJ, De Long MJ, Talalay P. 1985. On the mechanism of induction of cancer-protective enzymes a unifying proposal. Proc. Natl. Acad. Sci. USA... 

More than 100 million Americans regularly use dietary supplements, and in the year 2000, consumers spent about 16 billion on them. Furthermore, 39% of Americans say they have made dietary changes to reduce their risk of getting cancer, 43% claim to take a daily multivitamin for cancer protection, while 21% take another form of nutritional or dietary supplement (i.e., concentrated doses of single vitamins, minerals, or herbal substances) to lower their cancer risk. ... 

Ip C, Hayes C. 1989. Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection. Carcinogenesis 10(5) 921-925. 

The cancer-protective effeds of selenium are abolished by even small (stoichiometric)... 

Protease inhibitors in soybeans, known as trypsin inhibitors (TIs), play important roles in nutritional properties of soybeans and soy protein products. Two types of TI are the Kunitz inhibitor and the Bowman-Birk inhibitor. The Kunitz inhibitor has a MW of 21,500 with two disulfide bonds, while the Bowman-Birk inhibitor has a MW of 7,900 with seven disulfide bonds (Wolf, 1977). The large ratio of disulfide bonds to MW in the Bowman-Birk inhibitor stabilizes protein conformation and makes the Bowman-Birk inhibitor highly resistant to heat denaturation and inactivation. The Kunitz inhibitor inhibits trypsin, while the Bowman-Birk inhibitor inhibits both trypsin and chymotrypsin. The kinetics of TI inactivation when heating at high water activity were determined by Johnson et al. (1980) they estimated that 83-91% of the TI activity in soybeans is due to the Kunitz inhibitor. Recently, the Bowman-Birk inhibitor was attributed cancer-protecting qualities and also interest exists in using purified soy TI to treat AIDS patients (Kennedy, 1995, 1998 Kennedy Szuhaj, 1994). 

An article about the apparent link between aging and cancer protection.]... 

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