Cell Cancer Protection

Four phenolic compounds were isolated from the seeds by solvent fractionation Sephadex LJ-20 column chromatography and preparative HPLC, and three of them 

Effects on cell cycle ofthe most active cis (6b, 6c) and tram (5b, Sf) were examined by flow cytometry after cells were stained with propidium iodide. HL-60 cells were exposed to each compound at the concentrations reported in Ref [35]. (Reproduced with permission from Elsevier.) 

Similar to resveratrol, compounds 5b, Sf, and 6c induced a partial block of cells in S-phase and an apoptotic sub-GO-Gl peak corresponding to about 20%, suggesting that these compounds act on HL-60 cells as phase-specific cytotoxic agents. In contrast, compound 6b caused an evident sub-GO-Gl peak increase but no modification in cell cycle distribution (phases GO-Gl, S, and G2-M) compared to the control group. 

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Radioisotopes are also used in radiation therapy to treat cancer. The goal in radiation therapy is to kill malignant cells, while protecting healthy tissue from radiation effects. Radioisotopes such as yttrium-90, a beta emitter, may be placed directly in the tumor. Alternatively, the diseased tissue may be subjected to beams of gamma radiation. Cobalt-60 used in radiation therapy is prepared by a series of transmutations ... 

Bhattacharyya S, Mandal D, Sen GS, Pal S, Banerjee S, Lahiry L, Finke JH, Tannenbaum CS, Das T, Sa G. 2007. Tumor-induced oxidative stress perturbs nuclear factor-kappaB activity-augmenting tumor necrosis factor-alpha-mediated T-cell death Protection by curcumin. Cancer Res 67 362-370. 

Free-radical-induced reproductive cell death is the basis of radiotherapy, and it is obvious that the main problem of this approach to fight cancer is to target the ionizing radiation to the tumor in order to prevent damage to healthy tissue. This is a most difficult if not impossible task. Radiation modifiers that sensitize the tumor cells and protect healthy tissue are considered for improving treatment regimes in radiotherapy, and the underlying mechanistic principles are addressed. 

Vitiligo No safe and relfable treatment. Methoxsalen or other psoralen. Topically or syscemically, plus daily exposure to UVA (PUVA) is toxic, and ineffective in Caucasians. Sunscreens to protect the depigmented areas and reduce pigmentation of surrounding skin. Probably an autoimmune disease Note dose-dependent risk of squamous cell cancer with PUVA... 

In a chapter titled Enzymes Versus Cancer, Hasselberger traces the discovery in 1934 by Freund, in Vienna, of a normal substance that dissolves cancer cells (Hasselberger, 1978, p. 141ff). This mysterious substance is not found in the blood or serum of cancer patients, nor in the urine. In its absence, cancer cells were protected against dissolution by normal serum. Furthermore, when sufficient cancer serum lacking the normal substance was added to normal serum, the cell-sphtting ability of the normal serum was lost. 

Hwang et ah declared that polysaccharide extracted from Capsosiphon fulvescens inhibited alcohol-induced cell death and reduced the expressions of cyclooxygenase-2 (COX-2) and the inducible form of nitric oxide (iNOS), proteins related to ulcers (Hwang et ah, 2008). They proved that polysaccharide from marine algae also can be used as cancer protection agent. 

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