Cancer, lung, increase

Cytotoxic—inhibits growth of carcinoma of the urinary bladder, breasts, esophagus, thorax, and lungs. Increases secretion of cytokins, mainly IL-1 and TNF-a factor Protective factor against cancer Stimulates development of breast cancer Being incorporated into cellular membranes, fats modulate the activity of macrophages. They disturb proliferation of lymphocytes and depress activity of cytotoxic cells They disturb the response dependent on both B and T cells... 

Cancer The increased risk of cancer in vitamin deficiency is thought to be the result of depletion in beta-carotene. Beta-carotene is a very effective antioxidant and is suspected to reduce the risk of cancer is known to be initiated, by the production of free radicals. Of particular interest is the potential benefit of increased b-carotene intake to reduce the risk of lung cancer in smokers. However, caution needs to be taken when increasing the intake of any of the lipid soluble vitamins. 

Tobacco smoking is the major cause of lung cancer, accounting for almost 90% of all lung cancers. Lung cancer risks for smokers, however, increase dramatically when smokers are exposed to other lung carcinogens. 

The problems of ozone depletion in the upper atmosphere have led to increased problems of exposure of the skin to solar ultraviolet radiation [74]. Ultraviolet radiation to earth, due to the above effect could gradually affect human s immune system. Ailments like cataract, lung diseases and skin cancer would increase. Approximately 90% of non-melanoma and 65% of melanoma skin cancers have been attributed to ultraviolet exposure. 

CHRONIC HEALTH RISKS irritation of skin and mucous membranes dermatitis rhinitis pharyngitis conjunctivitis skin lesions hyper-pigmentation gangrene of the extremities vascular lesions exfoliation herpes appearance of small corns or warts increased risk of nonmelanoma skin cancer lung cancer bladder and liver cancer tumors of mouth, esophagus, larynx, bladder, para nasal sinus liver or kidney damage lower than normal birth weights. 

Zucker et al. reported results of plasma MMP-7 measurements using an ELISA. A bimodal distribution of values was observed in the normal population. Patients with bladder cancer, but not breast, GI, lung, gynecologic, and prostate cancer, demonstrated increased plasma MMP-7 levels (Z3). 

Yet, despite gains in treating many cancers and improved survival rates, cancer deaths continue to mount. While 143 people per 100,000 died of cancer in 1930, today the figure is nearly 180 per 100,000. Much of this increase is due to increased life expectancy (cancer incidence increases with age) and to marked increases in lung cancer. If current trends continue, cancer is expected to be the leading cause of death in the United States by the year 2010. ... 

Hendler, F.J. and Ozanne, B.W., Human squamous cell lung cancers express increased epidermal growth factor receptors, J. Clin. Invest, 74, 647, 1984. 

According to recent epidemiological studies, the majority of cancer cases derive from environmental causes, whose factors are attributed to either the indoor environment or outdoor air pollution and soil contamination (Doll and Peto 1981). In deed, the relative risk of lung cancer mortality increases by some 8—27% in heavily polluted areas (Beeson et al. 1998). Ghazaouet city homes the complex of non-ferrous metals (En-Metanof) which uses the pyrometallurgical process. It uses 100000-115000 t/year of raw material for polymetallic sulphide (El Abed blend), and produces 30000-40000 t/year of Zn, 100-150 t/year of Cd and 50000-80000 t/year of H2SO4. 

The results of these studies are consistent and demonstrate that the frequency of respiratory cancer mortality increased with increasing exposure to radiation (cumulative WLMs). Statistically significant excesses in lung cancer deaths were present after cumulative exposures of less than 50 WLMs in the Czechoslovakian cohort (Sevc et al. 1988) and at cumulative exposures greater than 100 WLMs in the cohorts from the United States and Ontario, Canada (Muller et al. 1985 Samet et al. 1989 Waxweiler et al. 1981). These studies indicate that lung cancer mortality was influenced by the total cumulative radiation exposure, by the age at first exposure, and by the time-course of the exposure accumulation. Most deaths from respiratory cancers occurred 10 or more years after the individual... 

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