Cancer Hepatomas

Ardisia quinquegona (Blume) Nakai A. sieboldii Miq. Zhi Jin Niu Shu Gi (Spiceberry) (leaf, root) Bergenin.50 Treat cancer, hepatoma, a diuretic, antidote for poison, antiphlegmatic. 

Iris pallasii Fisch. Ma Lan Zi (North China iris) (seed) Irisquinone.33 Treat cancer, hepatoma, lymphatic sarcoma. 

Iris pallasii Fisch. Irisquinone.33 Treat cancer, hepatoma, lymphatic sarcoma. 

Corrocher, R, Casaril, M., Bellisola, G., Gabrielli, G.B., Nicoli, N., Guidi, G.C. and DeSandre, G. (1986). Severe impairment of antioxidant systems in human hepatoma. Cancer 58, 1658-1662. 

Neoplasms (e.g., hepatoma, cholangiocarcinoma, hepatoblastoma, and bile duct cancer)... 

Liu J, Shen HM, Ong CN. Salvia miltiorrhiza inhibits cell growth and induces apoptosis in human hepatoma HepG2 cells. Cancer Lett 2000 153 85-93. 

Kozuki, Y, Y Miura, and K Yagasaki. 2000. Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture. Cancer Lett 151 111-115. 

Liu X, Tian P, Yu Y, Yao M, Cao X, Gu J (2002) Enhanced antitumor effect of EGF R-targeted p21WAF-l and GM-CSF gene transfer in the established murine hepatoma by peritumoral injection. Cancer Gene Ther 9 100-108... 

Na K, Park KH, Kim SW et al (2000) Self-assembled hydrogel nanoparticles from curdlan derivatives characterization, anti-cancer drug release and interaction with a hepatoma cell line (HepG2). J Control Release 69 225-236... 

Sensitivity of cancerous cells to copper may reflect cell DNA content. Two closely related rat hepatoma cell lines differed in sensitivity to copper toxicity by a factor of four DNA content in each cell line decreased with increasing copper concentrations, but at different rates. Severity of toxicity was associated with increasing accumulations of copper in the cell nucleus and with decreasing DNA (Toussaint and Nederbragt 1993). 

Y. I. Kageyama, Y. Yamazaki, A. S. Afify, Y. Ogawa, T. Okada, H. Okuno, Stereoselective Hydrolysis of Xenobiotic Esters by Different Cell Lines from Rat Liver and Hepatoma and Its Application to Chiral Prodrugs for Designated Growth Suppression of Cancer Cell , Chirality 1995, 7, 297 - 304. 

Eschenbrenner AB, Miller E. 1945a. Induction of hepatomas in mice by repeated oral administration of chloroform, with observations on sex differences. J Natl Cancer Inst 5 251-255. 

Sewell JM, Mayer I, Langdon SP, Smyth JF, Jodrell DI, Guichard SM. (2005) The mechanism of action of Kahalalide F Variable ceU permeability in human hepatoma cell hues. Eur J Cancer 41 1637-1644. 

Anwar-Mohamed A, El-Kadi, AOS. (2009) Sulforaphane induces CYPlAl mRNA, protein, and catalytic activity levels via an AhR-dependant pathway in murine hepatoma Hepa IclcV and human Hep62 cells. Cancer Lett 275 93-101. 

Hon J, Wang D, Zhang R, Wang H. (2008) Experimental therapy of hepatoma with artemisinin and its derivatives In vitro an in vivo activity, chemosensitization, and mechanisms of action. Clin Cancer Res 14 5519-5530. 

Gorrod JW, Carter RL, Roe FJC Induction of hepatomas by 4-aminobiphenyl and three of its hydroxylated derivatives administered to newborn mice. J Natl Cancer Inst 41 403-410, 1968... 

In humans, cases of hepatomas have appeared years after acute exposure to carbon tetrachloride, however, none of the cases could establish a causal link between the exposure and development of neoplasms." Epidemiological studies have also given inconclusive results. A cancer mortality study of a population of rubber workers reported a significantly elevated odds ratio relating carbon tetrachloride with lymphatic leukemia, and lymphosarcoma and reticulum cell carcinoma." A recent retrospective cohort mortality study of aircraft maintenance workers found an increased risk of... 

Eschenbrenner AB, Miller E Studies on hepatomas-size and spacing of multiple doses in the induction of carbon tetrachloride hepatomas. J Natl Cancer Inst 4 385-388, 1943... 

No excess of cancer was reported in two follow-up smdies of affected individuals in Turkey about 20-30 years after consumption of contaminated grain had ceased. " In mice, liver tumors were observed after exposure to HCB at 12-24mg/kg/day in the diet, but not at 6mg/kg/day. Hepatomas, hepatocellular carcinomas, bile duct adenomas, and renal cell adenomas were observed in rats after dietary administration." Liver tumors were also observed in 100% of surviving females and 16% of males after dietary administration to rats for 90 weeks. In another study, increased incidence of parathyroid adenomas and adrenal pheochromocytomas were observed in male and female rats and liver neoplastic nodules in females of the Ei generation in a two-generation feeding study. 

Diaconu CC, Szathmari M, Keri G, Venetianer A (1999) Apoptosis is induced in both drug-sensitive and multidrug-resistant hepatoma cells by somatostatin analogue TT-232. Br J Cancer 80 1197-1203... 

Andervont HB. 1958. Induction of hepatomas in strain C3II mice with 4-0- tolylazo-o-toluidine and carbon tetrachloride. J Natl Cancer Inst 20 431-438. 

Edwards J, Heston WE, Dalton AJ. 1942. Induction of the carbon tetrachloride hepatoma in strain L mice. J Natl Cancer Inst 3 297-301. 

Cell lines established from human liver cancer cells can be derived from primary hepatocellular carcinoma or hepatoblastoma cells [10]. For example, the well known HepG2 fine was derived from hepatoblastoma cells. Such cells can be employed effectively if the function of normal liver cells has been highly preserved. In practice, however, such cells contain a high proportion of abnormal genetic component, which inhibits their ability to express normal protein synthesis and enzyme activity. Potential problems, such as the loss of liver specific functions and the possibifity of metastasis, which could arise from the use of hepatoma cells have not yet been satisfactorily discussed [13]. 

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