Neoplastic livers

Malins, D.C. and Haimanot, R. (1990). 4,6,-Diamino-5-formamido-pyrimidine, 8-hydroxyguanine and 8-hydroxyadenine in DNA from neoplastic liver of English sole exposed to carcinogens. Biochem. Biophys. Res. Commun. 173, 614-619. 

No treatment-related gross or histopathological lesions in the liver were observed in rats in the chronic experiment by NTP (1986), but dosed male mice had increased coagulative necrosis and hepatocytomegaly, along with increased incidences of hepatocellular adenomas and carcinomas (see Section 2.2.2.8 on carcinogenicity). Female mice, however, did not have treatment-related lesions in the liver. The highest dose (500 mg/kg/day) is indicated as a NOAEL for liver effects in rats, while the low dose (250 mg/kg/day) is indicated as a LOAEL for non-neoplastic liver lesions in... 

Chiriboga, L., Yee, H. and Diem, M. (2000) Infrared spectroscopy of human cells and tissue. Part VII FT-IR microscopy of DNAase- and RNAase-treated normal, cirrhotic, and neoplastic liver tissue. Appl. Spectrosc. 54, 480-5. 

Chang LW, Pereira MA, Klaunig JE. 1985. Cytotoxicity of halogenated alkanes in primary cultures of rat hepatocytes from normal, partially hepatectomized, and preneoplastic/neoplastic liver. Toxicol AppI Pharmacol 80 274-283. 

Grieco, A., Castellano, R., Matera, A., Marcoccia, S., Di Rocco, P., Ragazoni, E., Vecchio, F.M., Gasbarrini, G. Antipyrine clearance in chronic and neoplastic liver diseases a study of 518 patients. J. Gastroenterol. Hepatol. 1998 13 460-466... 

Weltman 1985), or Aroclor 1260 at 5 mg/kg/day for 21 months (Kimbrough et al. 1975). Although preneoplastic and neoplastic liver lesions were induced in these as well as other rat studies (see Section 3.2.8.3.2), no nonproliferative changes, or nonproliferative lesions that did not progress to liver neoplasms after 1 year, were described. 

Only one control rat had gross abnormalities of the liver. Hepatocellular carcinomas were diagnosed in 14.1% (26 of 184) of the treated rats and 0.6% (1 of 173) of the controls. Neoplastic nodules were found in 84.7% (144 of 170) of the treated rats with surface nodules and in none of the controls (0 of 173). The total reported incidence of neoplastic liver lesions was 92.4% (170 of 184) in treated rats and 0.6% (1 of 173) in controls. Incidences of neoplastic lesions were not increased in tissues other than liver (all major tissues and organs were examined). 

Negro E, Papotti M, Taraglio S, et al. Relationship between hepatocyte proliferation and hepatitis delta virus replication in neoplastic and non-neoplastic liver tissues. J Viral Hepat. 1997 4 93-98. 

Based on the limited evidence of carcinogenicity in animals in the NTP bioassay (significantly increased incidences of neoplastic liver nodules in rats and combined hepatocellular adenomas and carcinomas in mice), as well as the lack of human data, decaBDE has been classified in EPA Group C (possible human carcinogen) and lARC Group 3 (not classifiable as to its carcinogenicity to humans)" (p.45). 

LI Lafarge, C. and Frayssinet, C. Minor role of the de novo pathway in the biosynthesis of RNA during fetal and neoplastic liver development in rats. Biochimie, 54, 471-481 (1972) (French)... 

Attempts to Induce or Restore GIucose-6-phosphatase Activity in Neoplastic Liver. 122... 

Fig. 12.6. Fibrolamellar hepatocellular carcinoma. Cords of neoplastic liver cells are separated by lamellar fibrous strands (X75)...

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