Hydrogel nanoparticles self-assembled

Chitosan matrix is known to be the superior matrix for immobilization of various biological organisms or its elements. Valerio et al. demonstrated high operational stability of invertase from Saccharomyces cerevisiae immobilized on chitosan nanoparticles [394], Similarly Luo et al. explored electrochemically deposited chitosan hydrogel for horseradish peroxidase immobilization through gold nanoparticles self-assembly [395]. 

Akiyoshi K, Kobayashi S, Shichibe S et al (1998) Self-assembled hydrogel nanoparticle of cholesterol-bearing pullulan as a carrier of protein drugs Complexation and stabilization of insulin. J Control Release 54 313-320... 

Na K, Park KH, Kim SW et al (2000) Self-assembled hydrogel nanoparticles from curdlan derivatives characterization, anti-cancer drug release and interaction with a hepatoma cell line (HepG2). J Control Release 69 225-236... 

Na, K., and Bae, Y. H. (2002),Self-assembled hydrogel nanoparticles responsive to tumor extracellular pH from pullulan derivative/sulfonamide conjugate Characterization, aggregation, and adriamycin release in vitro, Pharm. Res., 19(5), 681-688. 

Na, K., Lee, K. H., and Bae, Y. H. (2004), pH-sensitivity and pH-dependent interior structural change of self-assembled hydrogel nanoparticles of pullulan acetate/oligo-sulfonamide conjugate,/. Controlled Release, 97(3), 513-525. 

Fig. 4 Self-assembled hydrogel nanoparticles of hydrophobically modified polysaccharides. Note that nanoparticles have multiple inner cores which physically cross-link the hydrophilic polysaccharide chain. (Modified from Ref...

Akiyoshi, K. Deguchi, S. Tajima, H. Nishikawa, T. Sunamoto, J. Microscopic structure and thermoresponsiveness of a hydrogel nanoparticle by self-assembly of a hydrophobized polysaccharide. Macromolecules 1997, 30, 857-861. 

Kim, I.S. Jeong, Y.I. Kim, S.H. Self-assembled hydrogel nanoparticles composed of dextran and poly(ethylene glycol) macromer. Int. J. Pharm. 2000, 205, 109-116. 

Akiyoshi K., Nishikawa T., Kobayashi S.-I., Sunamoto J. Self-assembled hydrogel nanoparticles complexation and stabilization of soluble proteins. In Yalpani M., ed. Biomedical Function and Biotechnology of Natural and Artificial Polymers. ATL Press 1996 115-125. 

Nishikawa, T, Akiyoshi, K., Sunamoto, J. (1996). Macromolecular complexation between bovine serum albumin and die self-assembled hydrogel nanoparticle of hy-drophobized polysaccharides, J. Am. Chem. Soc., 118 6110. 

Key words nanoparticles, nano-carriers, nanovaccines, in vivo diagnostics, self-assembled hydrogels, nanocomposites. 

Hong JS, Stavis SM, Lacerda SHD, Locascio LE, Raghavan SR, Gaitan M (2010) Microfluidic directed self-assembly of liposome-hydrogel hybrid nanoparticles. Langmuir 26(13) 11581-11588... 

Due to its unique viscoelastic properties, HA is used as a drug delivery vehicle particularly in the form of nanoparticles [64—67]. Figure 1.6 shows an example of self-assembled fluorescently labeled HA nanoparticles, which were used for tumor targeting. HA hydrogels have been used to deliver chemotherapeutics [66, 67], antibiotics [68] and growth factors/proteins [69, 70]. Composites of HA have also... 

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