Somatostatin analogue

T. A., Rueter, J.K., and Goodman, M. Synthesis, biological activities, and conformational studies of somatostatin analogues. Tetrahedron 2000, 56, 9819-9831. 

Licha K, Hessenius C, Becker A, Henklein P, Bauer M, Wisniewski S, Wiedenmann B, Semmler W (2001) Synthesis, characterization, and biological properties of cyanine-labeled somatostatin analogues as receptor-targeted fluorescent probes. Bioconjugate Chem 12 44—50... 

De Leo V, La Marca A, Morgante G, Severi FM, Petraglia F (2001) Administration of somatostatin analogue reduces uterine and myoma volume in women with uterine leiomyomata. Obstet Gynecol 75 632-633... 

K. Gademann, M. Ernst, D. Hoyer, D. Seebach, Synthesis and Biological Evaluation of a cyclo-/3-Tetrapeptide as a Somatostatin Analogue , Angew. Chem., Int. Ed. 1999, 38, 1223-1226. 

Moreover, the conversion rate of C-labelled cholic acid to C-DCA was significantly greater during OT than before the somatostatin analogue treatment. 

Octreotide is a somatostatin analogue it is used in the treatment of somatostatin-secreting pituitary tumors. 

Dasgupta P. Somatostatin analogues multiple roles in cellular proliferation, neoplasia, and angiogenesis. Pharmacol Ther 2004 102 61-85. 

Diaconu CC, Szathmari M, Keri G, Venetianer A (1999) Apoptosis is induced in both drug-sensitive and multidrug-resistant hepatoma cells by somatostatin analogue TT-232. Br J Cancer 80 1197-1203... 

Dopamine agonists are also used for the treatment of acromegaly, but although they are much cheaper than somatostatin analogues, they are also less effective, and rarely normalize serum GH concentrations. 

Octreotide Sandostatin) is a synthetic somatostatin analogue. It is used in a variety of situations and must be given subcutaneously or intravenously. Most commonly, it is used as a continuous intravenous infusion in patients hospitalized with bleeding varices, because it de-... 

Scheme 11 Structures of the Naturally Occurring Cyclic Hexapeptides Segetalin A, 2781 Bouvardin, 279-2801 Pneumocandin b, 284-2861 and of a Synthetic Cyclic Somatostatin Analogue 2871...

Amino-acid abbreviations are spelled out in Appendix V. Through a series of structure-activity relationship studies, the bioactive conformation and peptide sequences that produce undesirable biologic responses were identihed. Also identified were sequences susceptible to proteolysis, and a working-model compound that eliminated these sequences was proposed (Figure 4.6). This allowed the rational design of optimized somatostatin analogues with desirable biologic characteristics and activity and increased stability. 

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