Cancer Gene expression

Luo J, Isaacs WB, Trent JM, Duggan DJ. 2003. Looking beyond morphology cancer gene expression profiling using DNA microarrays. Cancer Invest 21 937. 

Rhodes DR, Kalyana-Sundaram S, Mahavisno V, et al. (2007) Oncomine 3.0 genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia 9, 166-80. 

Oncomine (http //www.oncomine.org) is a commonly used site for querying analyzed cancer gene expression data. Oncomine allows comparison of any two datasets from different cancers to determine the genes that are specifically expressed in the dataset of interest (11). 

Chibon, F. 2013. Cancer gene expression signatures—the rise and fall Eur. J. Cancer 49(S) 2000-2009. 

Clarke PA, te Poele R, Wooster R, Workman P (2001) Gene expression microarray analysis in cancer biology, pharmacology, and drug development progress and potential. Biochem Pharmacol 62 1311-1336... 

The inhibitors of RNA polymerase, which generates RNA from DNA, inhibit a crucial step in gene expression. Inhibition of the eukaryotic form of RNA polymerase is used in cancer chemotherapy and is also an important experimental tool. For example, actinomy-cin D binds to the guanine residues in DNA and blocks the movement of the eukaryotic RNA polymerase. Specific inhibitors of bacterial RNA polymerase can be used as antibacterial agents. Most of these inhibitors like rifamycin bind to the prokaryotic enzyme. 

Beere, H.M., Morimoto, R.I., Hickman, J.A. (1993). Investigations of mechanisms of drug-induced changes in gene expression N methylformamide-induced changes in synthesis of the M(r) 72,000 constitutive heat shock protein during commitment of HL-60 cells to granulocyte differentiation. Cancer Res. 53, 3034—3039. 

The test system was considerably less sensitive to endosulfan when mouse ER, rather than human ER, was used to mediate (3-gal activity (Ramamoorthy et al. 1997). In similar assays, endosulfan at 10 jM had no effect on (3-gal activity in yeast Saccharomyces) transfected with either the human or rainbow trout ER (Andersen et al. 1999). In addition, no effect was observed on transcriptional activation of HeLa cells transfected with plasmids containing an estrogen receptor as a responsive element (Shelby et al. 1996). Endosulfan also did not induce transient reporter gene expression in MCF-7 human breast cancer cells at an incubation concentration of 2.5 pM (Andersen et al. 1999). Maximum endosulfan-induced ER-mediated luciferase reporter gene expression occurred in vitro in a T47D human breast adenocarcinoma cell line at approximately 10 pM, while 50% expression of luciferase occurred at about 5.9 pM the maximum expression was approximately 59% of the effect from exposure to 0.03 nM estradiol (0.00003 pM) (Legler et al. 1999). Luciferase expression from combined treatment with endosulfan and dieldrin was additive over concentrations ranging from 3 to 8 pM. 

Li Y, Hong X, Hussain M, Sarkar SH, Li R, Sarkar FH. Gene expression profiling revealed novel molecular targets of docetaxel and estramustine combination treatment in prostate cancer cells. Mol Cancer Ther 2005 4 389-98. 

Ohnishi H, Asamoto M, Tujimura K, Hokaiwado N, Takahashi S, Ogawa K, et al. Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo. Cancer Sci 2004 95 936-42. 

Scherf U, Ross DT, Waltham M, Smith LH, Lee JK, Tanabe L et al. A gene expression database for the molecular biology of cancer. Nat Genet 2000 24 236-44. 

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