Novel dmgs

Jiang YM, Yamamoto M, Kobayashi Y, Yoshihara T, Liang Y, Terao S, Takeuchi H, Ishigaki S, Katsuno M, Adachi H, Niwa J, Tanaka F, Doyu M, Yoshida M, Hashizume Y, Sobue G (2005) Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis. Ann Neurol 57(2) 236-251 Johnstone RW (2002) Histone-deacetylase inhibitors novel dmgs for the treatment of cancer. Nat Rev Dmg Discov l(4) 287-299... 

Gershell, L.J. and Atkins, J.H. Timeline a brief history of novel dmg discovery technologies. Nat. Rev. Drug Disc. 2003, 2, 321-327. 

This work elegantly demonstrates power of combined ABPP and chemical genetics approaches in understanding microbial pathogenesis, and has made a very real contribution to the identification of potential novel dmg targets. 

Matsumoto, K. et al., Insulin enhances macrophage scavenger receptor-mediated endocytotic uptake of advanced glycation endproducts, J. Biol. Chem. 273,8630-8637,1998). There is some interest in receptor-mediated endocytosis for drug delivery (Selbo, P.K., Hogset, A., Prasmickaite, L., and Berg, K Photochemical internalization a novel dmg delivery system. Tumour Biol. 23, 102-112, 2002). 

Kingston DGI, Newman DJ. The search for novel dmg leads for predominately antimmor therapies by utilizing mother nature s pharmacophoric libraries. Curr. Opin. Drug Disc. Develop. 2005 8 207-227. 

Abiief review is presented of recent progress in antimicrobial dendrimers. Mention is made of how both speeifie interactions and non-specific interactions can be utilised to design multifunctional antimicrobial agents which might be more potent than their monofimctional cormterparts. Uses as novel dmg delivery systems are also mentioned. 24 refs. USA... 

Novel Dmg Delivery Systems Fundamentals, Developmental Concepts, Biomedical Assessments, Yie W Chien... 

This novel dmg was officially approved for clinical use in January 2009 by the Ministry of Health, Labour, and Welfare of Japan. This is the first pharmaceutical success ever achieved for a selective opioid k agonist. All the other compounds derived from modifications of U-50,488H have been withdrawn or halted in early clinical phase development. Furthermore, nalfurafine hydrochloride is recognized as the first nonnarcotic opioid drug in history. 

Projan, S. J. (2002) New (and not so new) antibacterial targets - from where and when will the novel dmgs come Curr. Opin. Pharmacol. 2, 513-522. 

Synthetic strategies for the construction of 5-carbolines A chemical ladder in search of novel dmgs 12COS377. 

Cellulosic membranes are developed as a novel dmg delivery system, which is expressed to use on the skin and used as a mucus membrane of stomach, ear, nose, eye, rectum, and vagina. The goal excipients of these preparations are adhesive and film-former polymers. Modified cellulose, especially cellulose ethers, are extensively applied in bio-adhesives such as nasal, vaginal, ocular, buccal, and transdermal inventions only or by blend with additional polymers. Further newly applied ethers of cellulose in bio-adhesives contain anionic ether derivatives such as sodium carboxy-methyl cellulose (NaCMC) and non-ionic cellulose ethers such as hydoxypropyl cellulose (HPC), carboxymethyl cellulose (CMC), hydroxyethyl cellulose, ethyl cellulose (EC), hydroxylpropylmethyl cellulose (HPMC), or methyl cellulose (MC). Capability of polymer to absorb water from mucus and pH of objective area are main features defining the adhesive power of polymers. One benefit of cellulose ethers, such as HPC and NaCMC, is smaller dependence of adhesion period and their adhesion strength to pH of medium than thiolated bio-adhesive polymers and polyacrylate... 

Yokoyama, M., Miyauchi, M., Yamada, N., et al. (1990) Polymer Micelles As Novel Dmg Carrier - Adriamycin-Conjugated Poly(Ethylene Glycol) Poly(Aspartic Add) Block Copolymer, J. Com. Rel., 11, 269-78. 

Over the last few decades, quantum chemical calculations became a powerful alternative to experimental methods in medicinal and dmg chemistry in creating novel dmg candidates [1-3]. One of these modem approaches is based on elaboration of small molecules, binding to the active site of an enzyme and inhibiting the reaction catalyzed by the enzyme [4], These chemical substances should also exhibit... 

Microwave chemistry has become a central tool in this fast paced, time sensitive field and it has blossomed into a useful techrrique for a variety of applications in organic synthesis where high yielding protocols and facility of purifications are highly desirable (Bradley, 2001). Faced with the increasing demands of novel dmg targets, there is considerable current interest to accelerate this technology associated with combirratorial and computatiorral chemistry. 

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