Calcium edetate salt

Salt and chelate formation with edetate (ethylenediaminetetraacetate, EDTA). A In a solution of calcium disodium salt of EDTA, the sodium and hydrogen ions are chemically and biologically available. B In solutions of calcium disodium edetate, calcium is bound by coordinate-covalent bonds with nitrogens as well as by the usual ionic bonds. C In the lead-edetate chelate, lead is incorporated into five heterocyclic rings. 

Sodium calcium edetate can cause the same adverse effects as the disodium salt, with the exception of hypocalcemia. 

Edetic acid and edetate salts are used in pharmaceutical formulations, cosmetics, and foods as chelating agents. They form stable water-soluble complexes (chelates) with alkaline earth and heavy metal ions. The chelated form has few of the properties of the free ion, and for this reason chelating agents are often described as removing ions from solution this process is also called sequestering. The stability of the metal-edetate complex depends on the metal ion involved and also on the pH. The calcium chelate is relatively weak and will preferentially chelate heavy metals, such as iron, copper, and lead, with the release of calcium ions. For this reason, edetate calcium disodium is used therapeutically in cases of lead poisoning see also Section 18. 

Although edetic acid is fairly stable in the solid state, edetate salts are more stable than the free acid, which decarboxylates if heated above 150°C. Disodium edetate dihydrate loses water of crystallization when heated to 120°C. Edetate calcium disodium is slightly hygroscopic and should be protected from moisture. 

Synonyms calcium disodium edetate calcium disodium ethylenediaminetetraacetate calcium disodium (ethylene-dinitrilo)tetraacetate E385 edathamil calcium disodium edetic acid calcium disodium salt EDTA calcium ethylene-diaminetetraacetic acid calcium disodium chelate [(ethyl-enedinitrilo)tetraacetato]calciate(2-) disodium sodium calciumedetate Nersene CA. 

In general, piperazine and a good munber of its salts e.g., adipate, calcium edetate, citrate, phosphate and tartrate— have been employed profusely in therapeutic treatment of roundworm and pinworm infections. Piperazine itself is a representative example of this class of compoimds ... 

Calcium EDTA 11.28), injected as its sodium salt, sodium calcium edetate, is a most effective remedy for lead poisoning (Bessman, Rubin and Leikin, 1954). Sodium edetate (the same substance minus the calcium) was used in an attempt to decalcify stenosed valves in the heart even though it also caused a fall in blood calcium, the patients were none the worse after long courses of injections, e.g. 3 g (as a 0.5% solution) every 24 hours for 5 days a week, and 3 weeks per month (Seven, 1960). Sodium edetate has been used successfully to overcome digitalis-induced cardiac arrhythmia by restoring K /Ca - balance (Szekely and Wynne, 1963). 

Edetic acid calcium disodium salt. See Calcium disodium EDTA... 

Di-Na monO Ca salt [62-33-9]. Sodium calcium edetate, BAN, INN. Edetate calcium disodium, USAN. Edathamil calcium disodium. Calcium disodium versenate. Mosatil. Antallin. Ledclair. Other proprietary names Powerful chelating agent used for treatment of lead poisoning. Powder. Forms a tetrahydrate. 

Calcium play vital role in excitation - contraction coupling in myocardium. Calcium mediates contraction in vascular and other smooth muscles. Calcium is required for exocytosis and also involved in neurotransmitters release. Calcium also help in maintaining integrity of mucosal membranes and mediating cell adhesions. Hypercalcemia may occur in hyperthyroidism, vitamin D intoxication and renal insufficiency, which can be treated by administration of calcitonin, edetate sodium, oral phosphate etc. Hypocalcemia may occur in hypothyroidism, malabsorption, osteomalacia secondary to leak of vitamin D or vitamin D resistance, pancreatitis and renal failure. Hypocalcemia can be treated by chloride, gluconate, gluceptate, lactate and carbonate salts of calcium. 

Calcium Carbonate, 55 Calcium Chloride, 56, (Sl)5 Calcium Chloride, Anhydrous, 56 Calcium Chloride Double Salt of dl- or d-Calcium Pantothenate, 66 Calcium Chloride Solution, 57, (Sl)6 Calcium Chloride TS, 850 Calcium Citrate, 58, (S2)4 Calcium Disodium Edetate, 59 Calcium Disodium EDTA, 59 Calcium Disodium... 

Other salts of edetic acid that are commercially available include diammonium, dimagnesium, ferric sodium, and magnesium disodium edetates. Therapeutically, a dose of 50mg/kg body-weight of disodium edetate, as a slow infusion over a 24-hour period, with a maximum daily dose of 3 g, has been used as a treatment for hypercalcemia. For the treatment of lead poisoning, a dose of 60-80 mg/kg of edetate calcium disodium, as a slow infusion in two daily doses, for 5 days, has been used. 

Note A number of salts of EDTA are available with uses identical or similar to the acid. The USP salts are called edetates (calcium disodium, disodium edetates) others are usually abbreviated to EDTA (tetrasodium, trisodium EDTA). Other salts, known chiefly under trademark names, are the sodium ferric, dihydrogen ferrous and arange of disodium salts with magnesium, divalent cobalt, manganese, copper, zinc, and nickel. 

Solubility of the drug in the aqueous vehicle, even at 2 percent, was not an issue. Disodium edetate was included to prevent the drug from forming insoluble salts with metal ions such as calcium, zinc and magnesium. The tonicity of the solution was adjusted to within acceptable physiological limits by the addition of sodium chloride. 

EDTA, its sodium salt (edetate disodium, Na2EDTA), and a number of closely related compounds chelate many divalent and trivalent metals. The cation used to make a water-soluble salt of EDTA has an important role in the toxicity of the chelator. Na2EDTA causes hypocalcemic tetany. However, edetate calcium disodium (CaNa2EDTA) can be used for treatment of poisoning by metals that have higher affinity for the chelating agent than does Ca. ... 

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